Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Cartagena ES : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

MSC Cruises, MSC Magnifica

4 Night - Mediterranean
Starting in Barcelona, Spain, Genoa (Portofino), Italy, Marseille (Provence), France, Tarragona, Spain
2026 Sails: Oct 27, More...

Viking Ocean, Viking Vela

14 Night - Mediterranean Antiquities
Starting in Barcelona (Tarragona), Sete, Marseille, Monte Carlo, Florence / Pisa (Livorno), Rome (Civitavecchia), Naples, Sicily (Messina), Sail the Ionian Sea, Crete (Souda Bay), Ephesus (Kusadasi), Athens (Piraeus)
2026 Sails: Oct 27, More...

Viking Ocean, Viking Vela

7 Night - Iconic Western Mediterranean
Starting in Barcelona (Tarragona), Sete, Marseille, Monte Carlo, Florence / Pisa (Livorno), Rome (Civitavecchia)
2026 Sails: Oct 27, More...

Viking Ocean, Viking Vesta

15 Night - Malta, Morocco & the Mediterranean
Starting in Barcelona, Marseille, Sardinia (Olbia), Rome (Civitavecchia), Sail the Mediterranean Sea, Valletta, Tunis (La Goulette), Sail the Mediterranean Sea, Algiers, Sail the Strait of Gibraltar, Casablanca, Seville (Cadiz), Granada (Malaga), Sail the Balearic Sea, Barcelona
2026 Sails: Oct 27, More...

Windstar Tours, Wind Star Tours

14 Night - Next Stop Madrid : Spanish Treasures Cruise Tour
Starting in Madrid, Spain, Barcelona, Tarragona, Spain, Palma De Mallorca, Valencia, Cartagena ES, Malaga, Tangier, Lisbon
2026 Sails: Oct 27, More...

Norwegian Cruise Line, Norwegian Escape

16 Night - Repo - Transatlantic
Starting in Barcelona, Spain, Provence, Marseille, France, Palma Majorca, Spain, Cartagena ES, Spain, Motril, Spain, Cadiz / Seville, Spain, Tangier, Morocco, Las Palmas Gran Canaria, Spain, Orlando Beaches / Port Canaveral, Fl
2026 Sails: Oct 28, More...

Norwegian Cruise Line, Norwegian Star

11 Night - Canary Islands / Morocco
Starting in Barcelona, Spain, Motril, Spain, Cadiz / Seville, Spain, Casablanca, Morocco, Agadir, Morocco, Arrecife, Spain, Santa Cruz de Tenerife, Funchal, Portugal, Oporto, Portugal, Lisbon, Portugal
2026 Sails: Oct 29, More...

Oceania Cruises, Oceania Sirena

7 Night - Costa Brave & Italy
Starting in Barcelona (Tarragona), Palamos, Provence (Marseille), Ajaccio (Corsica), Cinque Terre (La Spezia), Olbia / Porto Cervo (Sardinia), Naples / Pompeii, Rome (Civitavecchia)
2026 Sails: Oct 29, More...

Silversea, Silver Ray

10 Night - Barcelona to Barcelona
Starting in Barcelona, Marseille, Cannes, Palma De Mallorca, Malaga (Costa del Sol), Cartagena ES, Spain, Valencia, Barcelona
2026 Sails: Oct 29, More...

Celebrity Cruises, Celebrity Equinox

10 Night - Greece, Italy & Malta Cruise
Starting in Barcelona, Spain, Valletta, Malta, Chania (Souda), Crete, Greece, Olympia (Katakolon), Greece, Sicily (Messina), Italy, Naples, Italy, Rome (Civitavecchia), Italy, Barcelona, Spain
2026 Sails: Oct 30, Nov 9, More...

<= Back

More =>