Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Cartagena ES : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Explora Journeys, EXPLORA I

11 Night - A Journey of Beguiling Landscapes & Enchanting Mediterranean Delights
Starting in Barcelona, Alicante, Lisbon, Casablanca, Tangier, Malaga, Spain, Motril, Barcelona
2026 Sails: Oct 21, More...

Norwegian Line Tours, Norwegian Dawn Tours

10 Night - Explore Barcelona Pre Cruisetour
Starting in At Hotel, Barcelona, Spain, Palma Majorca, Spain, Alicante, Spain, Motril, Spain, Gibraltar, Cadiz / Seville, Spain, Portimao, Portugal, Lisbon, Portugal
2026 Sails: Oct 22, More...

Celebrity Cruises, Celebrity Xcel

16 Night - Spain & Bermuda Transatlantic
Starting in Barcelona, Spain, Cartagena ES, Malaga, Spain, Gibraltar, United Kingdom, Seville (Cadiz), Spain, Madeira (Funchal), Portugal, Royal Naval Dockyard, Bermuda, Miami, Florida
2026 Sails: Oct 23, More...

MSC Cruises, MSC Grandiosa

7 Night - Mediterranean
Starting in Palma De Mallorca (Balearic Islands), Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, La Spezia (Cinque Terre), Italy, Civitavecchia (Rome), Italy, Palma De Mallorca (Balearic Islands), Spain
2026 Sails: Oct 23, More...

MSC Cruises, MSC Orchestra

4 Night - Mediterranean
Starting in Tarragona, Spain, Valencia, Spain, Livorno (Florence), Italy, Civitavecchia (Rome), Italy
2026 Sails: Oct 23, More...

Viking Ocean, Viking Sea

13 Night - West Indies to Spain
Starting in Barcelona, Valencia, Sail the Alboran Sea, Sail the Atlantic Ocean, Madeira (Funchal), Sail the Atlantic Ocean, Philipsburg, San Juan
2026 Sails: Oct 23, More...

MSC Cruises, MSC Euribia

3 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy
2026 Sails: Oct 24, More...

MSC Cruises, MSC Euribia

7 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy, Palermo (Monreale), Italy, La Goulette, Tunisia, Barcelona, Spain
2026 Sails: Oct 24, Oct 31, Nov 7, Nov 14, Nov 21, Nov 28, Dec 5, Dec 12, Dec 19, Dec 26, 2027: Jan 2, Jan 9, Jan 16, Jan 23, Jan 30, Feb 6, Feb 13, Feb 20, Feb 27, Mar 6, Mar 13, Mar 20, Mar 27, Apr 3, More...

MSC Cruises, MSC Grandiosa

7 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, La Spezia (Cinque Terre), Italy, Civitavecchia (Rome), Italy, Palma De Mallorca (Balearic Islands), Spain, Barcelona, Spain
2026 Sails: Oct 24, More...

MSC Cruises, MSC Orchestra

3 Night - Mediterranean
Starting in Valencia, Spain, Livorno (Florence), Italy, Civitavecchia (Rome), Italy
2026 Sails: Oct 24, More...

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