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Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Departing from
Spain
Cruise Specials

Windstar, Wind Surf
Wind Surf7 Night - Yachtsman's Harbors of the Rivieras
Starting in Barcelona, Palamos, Sanary-sur-mer, Monte Carlo, Cannes, Portofino, Portoferraio, Rome
2026 Sails: Jun 30, More...
Windstar Tours, Wind Surf Tours
Wind Surf Tours10 Night - Vatican & Italian Riviera Cruise Tour
Starting in Barcelona, Palamos, Sanary-sur-mer, Monte Carlo, Cannes, Portofino, Portoferraio, Rome
2026 Sails: Jun 30, More...
Costa Cruise Lines, Costa Pacifica
Costa Pacifica7 Night - Western Mediterranean from Valencia
Starting in Valencia, Olbia, Civitavecchia, Savona, Toulon / La Seyne-sur-Mer, Palma De Mallorca, Valencia
2026 Sails: Jul 1, More...
Emerald Cruises, Emerald Radiance
Emerald Radiance13 Night - Barcelona to Lisbon & Secrets of the Douro
Starting in Barcelona, Barcelona / Porto, Porto / Pinhao, Pinhao / Vega de Terron, Vega de Terron / Salamanca, Pocinho / Regua, Regua, Porto, Porto / Lisbon, Lisbon
2026 Sails: Jul 1, Nov 4, 2027: May 5, Aug 25, Oct 6, More...
Celebrity Cruises, Celebrity Xcel
Celebrity Xcel7 Night - Italy & France Cruise
Starting in Barcelona, Spain, Provence (Marseille), France, Portofino, Italy, Florence / Pisa (La Spezia), Italy, Rome (Civitavecchia), Italy, Naples, Italy, Barcelona, Spain
2026 Sails: Jul 4, Aug 1, More...
Virgin Voyages, Valiant Lady
Valiant Lady7 Night - French Riviera, Italy, Rome & Ibiza
Starting in Barcelona, Spain, Rome (Civitavecchia), Italy, Florence / Pisa (Livorno), Italy, Cannes, France, Ibiza, Spain, Barcelona, Spain
2026 Sails: Jul 4, More...
MSC Cruises, MSC Opera
MSC Opera10 Night - Mediterranean
Starting in Malaga (Granada), Spain, Cadiz (Seville), Spain, Lisbon (Cascais), Portugal, Alicante, Spain, Mahon, Menorca, Spain, Olbia, Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Malaga (Granada), Spain
2026 Sails: Jul 5, More...
Regent Seven Seas, Seven Seas Navigator
Seven Seas Navigator14 Night - Landmarks of Lisbon & Lorient
Starting in Barcelona, Cruising the Mediterranean Sea, Malaga, Lisbon, Oporto, Cruising the Bay of Biscay, Bordeaux, Lorient, St Peter Port, Guernsey, Paris (Le Havre), Dunkirk, London (Dover UK)
2026 Sails: Jul 5, More...
Disney Cruise Line, Disney Dream
Disney Dream7 Night - Mediterranean Cruise from Barcelona
Starting in Barcelona, Livorno, Civitavecchia, Naples, Cagliari, Barcelona
2026 Sails: Jul 6, More...
Explora Journeys, EXPLORA I
EXPLORA I14 Night - An Extended Voyage of Antique Treasures, Volcanic Views & Tranquil Shores
Starting in Barcelona, Ibiza, Tunis / La Goulette, La Valletta, Giardini Naxos, Sorrento, Civitavecchia (Rome), Porto Santo Stefano (Argentario), Monte Carlo, Saint-Tropez, Valencia, Mahon (Menorca), Barcelona
2026 Sails: Jul 6, More...

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Spain Cruise Departures