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Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Cartagena ES : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Departing from
Spain
Cruise Specials

MSC Cruises, MSC Magnifica
MSC Magnifica4 Night - Mediterranean
Starting in Barcelona, Spain, Genoa (Portofino), Italy, Marseille (Provence), France, Barcelona, Spain
2026 Sails: Oct 19, Oct 23, More...
Celebrity Cruises, Celebrity Equinox
Celebrity Equinox10 Night - Italy, Spain & Malta Cruise
Starting in Barcelona, Spain, Palma De Mallorca, Spain, Florence / Pisa (La Spezia), Italy, Rome (Civitavecchia), Italy, Naples, Italy, Valletta, Malta, Sicily (Palermo), Italy, Barcelona, Spain
2026 Sails: Oct 20, More...
Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa3 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Marseille, Savona, Barcelona
2026 Sails: Oct 20, More...
MSC Cruises, MSC Euribia
MSC Euribia4 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Barcelona, Spain
2026 Sails: Oct 20, 2027: Apr 10, 2028: Apr 1, More...
MSC Cruises, MSC Meraviglia
MSC Meraviglia7 Night - Msc Grand Voyages
Starting in Barcelona, Spain, Alicante, Spain, Gibraltar, Cadiz (Seville), Spain, Casablanca (Marrakesh), Morocco, Las Palmas de Gran Canaria (Canary Islands), Spain, Funchal (Madeira Islands), Portugal
2026 Sails: Oct 20, More...
MSC Cruises, MSC Meraviglia
MSC Meraviglia22 Night - Msc Grand Voyages
Starting in Barcelona, Spain, Alicante, Spain, Gibraltar, Cadiz (Seville), Spain, Casablanca (Marrakesh), Morocco, Las Palmas de Gran Canaria (Canary Islands), Spain, Funchal (Madeira Islands), Portugal, Ponta Delgada (Azores), Portugal, Boston, New York City (Brooklyn), New York, Miami, Florida
2026 Sails: Oct 20, More...
Ritz-Carlton, Ilma
Ilma7 Night - Barcelona / Lisbon
Starting in Barcelona, Valencia, Cartagena ES, Malaga, Marbella, Tangier, Lisbon
2026 Sails: Oct 20, More...
AmaWaterways Tours, AmaVida Tours
AmaVida Tours13 Night - Flavors of Portugal & Spain with Madrid Pre-Cruise and Lisbon Post-Cruise
Starting in Madrid, Salamanca, Vega de Terron, Pinhao, El Dorado, Porto, Lisbon
2026 Sails: Oct 21, More...
Costa Cruise Lines, Costa Diadema
Costa Diadema10 Night - Mediterranean from Cadiz to Barcelona
Starting in Cadiz, Spain, Lisbon, Portugal, Gibraltar (UK), Malaga, Spain, Cartagena ES, Spain, Marseille, France, Savona, Italy, Barcelona, Spain
2026 Sails: Oct 21, More...
EXPLORA I27 Night - A Grand Journey of Colourful Moroccan Shores & Idyllic Caribbean Scenery
Starting in Barcelona, Alicante, Lisbon, Casablanca, Tangier, Malaga, Spain, Motril, Barcelona, Cadiz, Funchal (Madeira), St Johns AG, Antigua, Road Bay, San Juan, Miami
2026 Sails: Oct 21, More...

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Spain Cruise Departures