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Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Departing from
Spain
Cruise Specials

MSC Cruises, MSC Opera
MSC Opera10 Night - Mediterranean
Starting in Malaga (Granada), Spain, Cadiz (Seville), Spain, Lisbon (Cascais), Portugal, Alicante, Spain, Mahon, Menorca, Spain, Olbia, Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Malaga (Granada), Spain
2026 Sails: Jun 15, More...
Azamara Journey10 Night - Spain Intensive Cruise : Valencia, Malaga & Seville
Starting in Barcelona, Valencia, Palma, Majorca, Cartagena ES, Malaga, Gibraltar, Seville, Lisbon
2026 Sails: Jun 16, More...
Costa Cruise Lines, Costa Smeralda
Costa Smeralda6 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Palermo, Civitavecchia, Savona, Marseille, Barcelona
2026 Sails: Jun 16, More...
Oceania Sirena7 Night - Stars of Spain & Portugal
Starting in Barcelona, Valencia, Cartagena ES, Malaga, Gibraltar, Seville (Cadiz), Portimao, Lisbon
2026 Sails: Jun 16, More...
Costa Cruise Lines, Costa Pacifica
Costa Pacifica7 Night - Western Mediterranean from Alicante
Starting in Alicante, Olbia, Civitavecchia, Savona, Toulon / La Seyne-sur-Mer, Palma De Mallorca, Valencia
2026 Sails: Jun 17, More...
Celebrity Cruises, Celebrity Equinox
Celebrity Equinox10 Night - Greek Isles & Turkey
Starting in Barcelona, Spain, Valletta, Malta, Athens (Piraeus), Greece, Ephesus (Kusadasi), Turkey, Santorini, Greece, Mykonos, Greece, Olympia (Katakolon), Greece, Rome (Civitavecchia), Italy
2026 Sails: Jun 20, Sep 12, More...
Viking Ocean, Viking Star
Viking Star12 Night - Mediterranean Odyssey
Starting in Barcelona, Tarragona, Marseille, Monte Carlo, Florence / Pisa (Livorno), Rome (Civitavecchia), Naples, Sail the Ionian Sea, Corfu (Kerkyra), Dubrovnik, Croatia, Split, Venice (Chioggia)
2026 Sails: Jun 20, More...
Holland America, Oosterdam
Oosterdam7 Night - Greek Isles : Malta & Santorini
Starting in Barcelona, Spain, Valletta, Malta, Souda (Chania), Greece, Thira (Santorini), Greece, Kusadasi (Ephesus), Turkey, Piraeus (Athens), Greece
2026 Sails: Jun 21, Jul 12, 2027: Jun 26, Jul 17, More...
Holland America, Oosterdam
Oosterdam14 Night - Greek Isles : Malta & Cairo
Starting in Barcelona, Spain, Valletta, Malta, Souda (Chania), Greece, Thira (Santorini), Greece, Kusadasi (Ephesus), Turkey, Piraeus (Athens), Greece, Alexandria EG (Cairo), Egypt, Rhodes, Greece, Mykonos, Greece, Piraeus (Athens), Greece
2026 Sails: Jun 21, 2027: Jul 17, More...
Virgin Voyages, Valiant Lady
Valiant Lady7 Night - Italian Vistas to Spanish Sunsets
Starting in Barcelona, Spain, Civitavecchia (Rome), Italy, La Spezia, Italy, Cannes, France, Ibiza, Spain, Barcelona, Spain
2026 Sails: Jun 21, More...

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Spain Cruise Departures