Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Cunard Line, Queen Victoria

7 Night - Italy, France and Spain
Starting in Barcelona, Spain, Alghero, Sardinia, Italy, Ajaccio, Corsica, France, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Stromboli Sail By, IT, Salerno (tours to Capri or Pompeii), Italy, Amalfi Coast Sail By, IT, Civitavecchia (tours to Rome), Italy
2026 Sails: Jun 22, More...

Cunard Line, Queen Victoria

14 Night - Adriatic and Western Mediterranean
Starting in Barcelona, Spain, Alghero, Sardinia, Italy, Ajaccio, Corsica, France, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Stromboli Sail By, IT, Salerno (tours to Capri or Pompeii), Italy, Amalfi Coast Sail By, IT, Civitavecchia (tours to Rome), Italy, Messina Strait, Italy (Transit), Cephalonia, Greece, Corfu, Greece, Kotor, Montenegro, Split, Croatia, Trieste, Italy
2026 Sails: Jun 22, More...

Cunard Line, Queen Victoria

21 Night - Adriatic and Western Mediterranean
Starting in Barcelona, Spain, Alghero, Sardinia, Italy, Ajaccio, Corsica, France, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Stromboli Sail By, IT, Salerno (tours to Capri or Pompeii), Italy, Amalfi Coast Sail By, IT, Civitavecchia (tours to Rome), Italy, Messina Strait, Italy (Transit), Cephalonia, Greece, Corfu, Greece, Kotor, Montenegro, Split, Croatia, Trieste, Italy, Zadar, Croatia, Dubrovnik, Croatia, Valletta, Malta, Stromboli Sail By, IT, Naples (tours to Capri or Pompeii), Italy, Civitavecchia (tours to Rome), Italy
2026 Sails: Jun 22, More...

Explora Journeys, EXPLORA I

14 Night - An Extended Journey of Historic Discovery & Bewitching Scenery
Starting in Barcelona, Cannes, Portofino, Livorno (Florence), Porto Cervo (Sardinia), Ajaccio (Corsica), Civitavecchia (Rome), Port of Naples, Capri, Calvi (Corsica), Villefranche-Sur-Mer (Nice), Marseille, Mahon (Menorca), Barcelona
2026 Sails: Jun 22, More...

Explora Journeys, EXPLORA I

7 Night - A Journey Through the Picturesque Mediterranean & Historic Beauty of the Sparkling Riviera
Starting in Barcelona, Cannes, Portofino, Livorno (Florence), Porto Cervo (Sardinia), Ajaccio (Corsica), Civitavecchia (Rome)
2026 Sails: Jun 22, More...

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Palma De Mallorca
Starting in Palma De Mallorca, Valencia, Olbia, Civitavecchia, Savona, Marseille, Ibiza
2026 Sails: Jun 23, More...

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Valencia
Starting in Valencia, Olbia, Civitavecchia, Savona, Marseille, Ibiza, Valencia
2026 Sails: Jun 24, More...

MSC Cruises, MSC Opera

10 Night - Mediterranean
Starting in Malaga (Granada), Spain, Cadiz (Seville), Spain, Lisbon (Cascais), Portugal, Alicante, Spain, Mahon Minorque, Olbia, Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Malaga (Granada), Spain
2026 Sails: Jun 25, More...

Norwegian Line Tours, Norwegian Epic Tours

10 Night - Explore Barcelona Pre Cruisetour
Starting in At Hotel, Barcelona, Spain, Provence, Marseille, France, Nice / Monaco (Villefranche), France, Livorno / Florence / Pisa, Italy, Messina, Italy, Amalfi Coast (Salerno), Italy, Civitavecchia Rome, Italy
2026 Sails: Jun 25, Oct 15, More...

Oceania Cruises, Oceania Allura

12 Night - Southern Europe Sojourn
Starting in Barcelona, Provence (Marseille), Monte Carlo, Ajaccio (Corsica), Rome (Civitavecchia), Amalfi / Positano, Taormina (Sicily), Katakolon, Kotor, Dubrovnik, Croatia, Pula / Rovinj, Trieste
2026 Sails: Jun 25, More...

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