Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Costa Cruise Lines, Costa Diadema

3 Night - Southern Europe Roundtrip from Barcelona
Starting in Barcelona, Spain, Marseille, France, Savona, Italy, Barcelona, Spain
2026 Sails: Oct 31, More...

MSC Cruises, MSC Euribia

7 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy, Palermo (Monreale), Italy, La Goulette, Tunisia, Barcelona, Spain
2026 Sails: Oct 31, Nov 7, Nov 14, Nov 21, Nov 28, Dec 12, Dec 19, Dec 26, 2027: Jan 2, Jan 9, Jan 16, Jan 23, Jan 30, Feb 6, Feb 13, Feb 20, Feb 27, Mar 6, Mar 13, Mar 20, Mar 27, Apr 3, More...

MSC Cruises, MSC Grandiosa

14 Night - Msc Grand Voyages
Starting in Barcelona, Spain, Funchal (Madeira Islands), Portugal, San Juan, Puerto Rico, Miami, Florida, Port Canaveral (Orlando), Florida
2026 Sails: Oct 31, More...

MSC Cruises, MSC Grandiosa

13 Night - Msc Grand Voyages
Starting in Barcelona, Spain, Funchal (Madeira Islands), Portugal, San Juan, Puerto Rico, Miami, Florida
2026 Sails: Oct 31, More...

MSC Cruises, MSC Magnifica

5 Night - Mediterranean
Starting in Tarragona, Spain, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Tarragona, Spain
2026 Sails: Oct 31, More...

MSC Cruises, MSC Sinfonia

6 Night - Mediterranean
Starting in Valencia, Spain, Tarragona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Livorno (Florence), Italy, Valencia, Spain
2026 Sails: Oct 31, More...

MSC Cruises, MSC Sinfonia

2 Night - Mediterranean
Starting in Valencia, Spain, Tarragona, Spain, Marseille (Provence), France
2026 Sails: Oct 31, More...

MSC Cruises, MSC Sinfonia

8 Night - Mediterranean
Starting in Valencia, Spain, Tarragona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Livorno (Florence), Italy, Valencia, Spain, Palma De Mallorca (Balearic Islands), Spain, Barcelona, Spain
2026 Sails: Oct 31, More...

Princess Cruises, Sun Princess

15 Night - Western Europe Passage
Starting in Barcelona, Spain, Malaga, Spain, Gibraltar, Seville (Cadiz), Spain, Santa Cruz de Tenerife, Fort Lauderdale, Florida
2026 Sails: Oct 31, More...

Royal Caribbean, Explorer of the Seas

13 Night - Spain, & Bermuda Transatlantic
Starting in Barcelona, Spain, Palma De Mallorca, Spain, Cartagena ES, Ponta Delgada, Azores, Royal Naval Dockyard, Bermuda, Orlando (Port Canaveral), Fl
2026 Sails: Oct 31, More...

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