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Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Departing from
Spain
Cruise Specials

AmaWaterways Tours, AmaKristina Tours
AmaKristina Tours13 Night - Colors of Provence with Barcelona Pre-Cruise and Paris Post-Cruise
Starting in Barcelona, Arles, Avignon, Viviers, Tournon, Vienne, Lyon, Paris
2026 Sails: Sep 14, Sep 28, Oct 12, 2027: Mar 15, Apr 12, Apr 26, May 10, May 24, Jun 7, Aug 2, Aug 16, Aug 30, Sep 13, Sep 27, More...
Costa Cruise Lines, Costa Smeralda
Costa Smeralda7 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Ibiza, Palermo, Civitavecchia (Rome), Savona, Marseille, Barcelona
2026 Sails: Sep 14, Sep 21, More...
Explora Journeys, EXPLORA I
EXPLORA I7 Night - A Journey from Elegance & Cultural Essence to Glamour & Antiquities
Starting in Barcelona, Porto Cervo (Sardinia), Ajaccio (Corsica), Saint-Tropez, Portofino, Livorno (Florence), Civitavecchia (Rome)
2026 Sails: Sep 14, More...
Royal Caribbean, Brilliance of the Seas
Brilliance of the Seas7 Night - Italy & France Cruise
Starting in Barcelona, Spain, Provence (Toulon), France, Ajaccio, Corsica, France, Rome (Civitavecchia), Italy, Naples, Italy, Sicily (Messina), Italy, Ravenna, Italy
2026 Sails: Sep 14, More...
Costa Cruise Lines, Costa Pacifica
Costa Pacifica7 Night - Western Mediterranean from Palma De Mallorca
Starting in Palma De Mallorca, Alicante, Olbia (costa Smeralda), Civitavecchia (Rome), Savona, La Seyne (St Tropez), Palma De Mallorca
2026 Sails: Sep 15, More...
MSC Cruises, MSC Meraviglia
MSC Meraviglia7 Night - Mediterranean
Starting in Barcelona, Spain, La Goulette, Tunisia, Palermo (Monreale), Italy, Naples (Pompeii), Italy, Livorno (Florence), Italy, Marseille (Provence), France, Barcelona, Spain
2026 Sails: Sep 15, Sep 22, Sep 29, Oct 6, Oct 13, More...
MSC Cruises, MSC Meraviglia
MSC Meraviglia3 Night - Mediterranean
Starting in Barcelona, Spain, La Goulette, Tunisia, Palermo (Monreale), Italy
2026 Sails: Sep 15, More...
Viking Ocean, Viking Vesta
Viking Vesta7 Night - Iconic Western Mediterranean
Starting in Barcelona, Sete, Marseille, Monte Carlo, Florence / Pisa (Livorno), Rome (Civitavecchia)
2026 Sails: Sep 15, More...
Costa Cruise Lines, Costa Pacifica
Costa Pacifica7 Night - Western Mediterranean from Alicante
Starting in Alicante, Olbia (costa Smeralda), Civitavecchia (Rome), Savona, La Seyne (St Tropez), Palma De Mallorca, Valencia
2026 Sails: Sep 16, More...
MSC Cruises, MSC Seaview
MSC Seaview7 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Palermo (Monreale), Italy, Ibiza (Balearic Islands), Spain, Barcelona, Spain
2026 Sails: Sep 17, Sep 24, Oct 1, Oct 8, Oct 15, Oct 22, Oct 29, More...

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Spain Cruise Departures