Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Cartagena ES : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Ritz-Carlton, Evrima

4 Night - Barcelona / Rome (Civitavecchia)
Starting in Barcelona, Monte Carlo, Portofino, Rome (Civitavecchia)
2026 Sails: Sep 8, More...

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Valencia
Starting in Valencia, Olbia, Civitavecchia (Rome), Savona, La Seyne (St Tropez), Palma De Mallorca, Alicante
2026 Sails: Sep 9, More...

Emerald Cruises, Emerald Sakara

9 Night - Spanish Shores & Beyond
Starting in Barcelona, Spain, Port-Vendres, France, Saint-Tropez, France, Monte Carlo, Monaco, Calvi, France, Porto Cervo, Italy, Mahon, Menorca, Spain, Ibiza, Spain, Palma De Mallorca, Spain
2026 Sails: Sep 10, More...

Windstar, Star Legend

22 Night - Star Collector : Greek Myths & Riviera Magic
Starting in Barcelona, Palamos, Sanary-sur-mer, Monte Carlo, Cannes, Portofino, Portoferraio, Porto Ercole, Rome, Sorrento, Messina (Taormina), Gythion, Monemvasia, Athens, Greece, Kusadasi, Kavala, Greece, Thessaloniki, Greece, Volos, Greece, Skopelos, Greece, Athens, Greece
2026 Sails: Sep 11, More...

Windstar, Star Legend

14 Night - Star Collector : Riches of the Rivieras, Romans, and Greeks
Starting in Barcelona, Palamos, Sanary-sur-mer, Monte Carlo, Cannes, Portofino, Portoferraio, Porto Ercole, Rome, Sorrento, Messina (Taormina), Gythion, Monemvasia, Athens, Greece
2026 Sails: Sep 11, More...

Windstar, Star Legend

8 Night - Yachtsman's Harbors of the Rivieras
Starting in Barcelona, Palamos, Sanary-sur-mer, Monte Carlo, Cannes, Portofino, Portoferraio, Porto Ercole, Rome
2026 Sails: Sep 11, More...

Windstar Tours, Star Legend Tours

10 Night - Vatican & Italian Riviera Cruise Tour
Starting in Barcelona, Palamos, Sanary-sur-mer, Monte Carlo, Cannes, Portofino, Portoferraio, Porto Ercole, Rome
2026 Sails: Sep 11, More...

Holland America, Oosterdam

21 Night - Mediterranean Explorer Collectors' Voyage
Starting in Barcelona, Spain, Marseille (Provence), France, Livorno (Florence / Pisa), Italy, Civitavecchia (Rome), Italy, Naples (Pompeii / Amalfi), Italy, Cruising Strait of Messina, Kerkira, (Corfu), Greece, Dubrovnik, Croatia, Kotor, Montenegro, Scenic cruising Bay of Kotor, Zadar, Croatia, Trieste (Venice), Italy, Rijeka, Croatia, Split, Croatia, Thira (Santorini), Greece, Bodrum, Turkey, Kusadasi (Ephesus), Turkey, Istanbul, Turkey, Cruising the Dardanelles, Piraeus (Athens), Greece
2026 Sails: Sep 12, More...

Holland America, Oosterdam

11 Night - Around Italy's Boot : Italy, Dalmatia & Venice
Starting in Barcelona, Spain, Marseille (Provence), France, Livorno (Florence / Pisa), Italy, Civitavecchia (Rome), Italy, Naples (Pompeii / Amalfi), Italy, Cruising Strait of Messina, Kerkira, (Corfu), Greece, Dubrovnik, Croatia, Kotor, Montenegro, Scenic cruising Bay of Kotor, Zadar, Croatia, Trieste (Venice), Italy
2026 Sails: Sep 12, More...

Viking Ocean, Viking Star

12 Night - Mediterranean Odyssey
Starting in Barcelona, Barcelona (Tarragona), Marseille, Monte Carlo, Florence / Pisa (Livorno), Rome (Civitavecchia), Naples, Sail the Ionian Sea, Corfu (Kerkyra), Dubrovnik, Croatia, Split, Venice (Chioggia)
2026 Sails: Sep 12, More...

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