Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Lindblad Expeditions, National Geographic Orion

12 Night - Mediterranean Wonders : Sicily, Greece, Sardinia and Beyond
Starting in Barcelona, Spain / Embark Ship, Ciutadella de Menorca, At Sea / Bonifacio, Corsica, France, Bonifacio, Golfo Aranci, Sardinia, Italy, At Sea / Aeolian Islands, Taormina, Sicily, Siracusa / At Sea, Corfu, Greece, Cephalonia, Delphi / Corinth Canal, Athens / Disembark Ship
2026 Sails: May 22, 2027: Apr 7, Aug 9, More...

Disney Cruise Line, Disney Dream

7 Night - Mediterranean Cruise from Barcelona
Starting in Barcelona, Cagliari, Naples, Civitavecchia, Livorno, Barcelona
2026 Sails: May 23, More...

Royal Caribbean, Harmony of the Seas

7 Night - Western Mediterranean Cruise
Starting in Barcelona, Spain, Palma De Mallorca, Spain, Provence (Marseille), France, Florence / Pisa (La Spezia), Italy, Rome (Civitavecchia), Italy, Naples, Italy, Barcelona, Spain
2026 Sails: May 24, May 31, Jun 7, More...

Cunard Line, Queen Victoria

7 Night - Italy, France and Spain
Starting in Barcelona, Spain, Palma De Mallorca, Spain, Ajaccio, Corsica, France, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Salerno (tours to Capri or Pompeii), Italy, Amalfi Coast Sail By, IT, Civitavecchia (tours to Rome), Italy
2026 Sails: May 25, More...

Cunard Line, Queen Victoria

14 Night - Adriatic and Western Mediterranean
Starting in Barcelona, Spain, Palma De Mallorca, Spain, Ajaccio, Corsica, France, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Salerno (tours to Capri or Pompeii), Italy, Amalfi Coast Sail By, IT, Civitavecchia (tours to Rome), Italy, Messina Strait, Italy (Transit), Cephalonia, Greece, Corfu, Greece, Kotor, Montenegro, Split, Croatia, Trieste, Italy
2026 Sails: May 25, More...

Cunard Line, Queen Victoria

21 Night - Adriatic and Western Mediterranean
Starting in Barcelona, Spain, Palma De Mallorca, Spain, Ajaccio, Corsica, France, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Salerno (tours to Capri or Pompeii), Italy, Amalfi Coast Sail By, IT, Civitavecchia (tours to Rome), Italy, Messina Strait, Italy (Transit), Cephalonia, Greece, Corfu, Greece, Kotor, Montenegro, Split, Croatia, Trieste, Italy, Zadar, Croatia, Dubrovnik, Croatia, Valletta, Malta, Palma De Mallorca, Spain, Barcelona, Spain
2026 Sails: May 25, More...

Azamara Cruises, Azamara Journey

Deal link -> Special

7 Night - France Intensive Cruise : Marseille, Saint-Tropez & Nice
Starting in Barcelona, Port Vendres, Sete, Provence (Marseille), Sanary-sur-mer, St Tropez, Nice
2026 Sails: May 26, More...

MSC Cruises, MSC Opera

10 Night - Mediterranean
Starting in Malaga (Granada), Spain, Cadiz (Seville), Spain, Lisbon (Cascais), Portugal, Alicante, Spain, Mahon, Spain, Olbia, Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Malaga (Granada), Spain
2026 Sails: May 26, Jun 5, Jul 15, Jul 25, Aug 4, Aug 14, Aug 24, Sep 3, Sep 23, More...

Viking Ocean, Viking Vesta

7 Night - Iconic Western Mediterranean
Starting in Barcelona, Sete, Marseille, Monte Carlo, Florence / Pisa (Livorno), Rome (Civitavecchia)
2026 Sails: May 26, Jul 21, Sep 15, 2027: Nov 16, More...

Viking Ocean, Viking Vesta

14 Night - Mediterranean & Italian Sojourn
Starting in Barcelona, Sete, Marseille, Monte Carlo, Florence / Pisa (Livorno), Rome (Civitavecchia), Naples, Sicily (Messina), Crotone, Bari, Sibenik, Venice (Fusina)
2026 Sails: May 26, Jul 21, More...

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