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Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Departing from
Spain
Cruise Specials

MSC Cruises, MSC Orchestra
MSC Orchestra4 Night - Mediterranean
Starting in Tarragona, Spain, Valencia, Spain, Livorno (Florence), Italy, Civitavecchia (Rome), Italy
2026 Sails: Oct 23, More...
Viking Ocean, Viking Sea
Viking Sea13 Night - West Indies to Spain
Starting in Barcelona, Valencia, Sail the Alboran Sea, Sail the Atlantic Ocean, Madeira (Funchal), Sail the Atlantic Ocean, Philipsburg, San Juan
2026 Sails: Oct 23, More...
MSC Cruises, MSC Euribia
MSC Euribia7 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy, Palermo (Monreale), Italy, La Goulette, Tunisia, Barcelona, Spain
2026 Sails: Oct 24, Oct 31, Nov 7, Nov 14, Nov 21, Nov 28, Dec 5, Dec 12, Dec 19, Dec 26, 2027: Jan 2, Jan 9, Jan 16, Jan 23, Jan 30, Feb 6, Feb 13, Feb 20, Feb 27, Mar 6, Mar 13, Mar 20, Mar 27, Apr 3, More...
MSC Cruises, MSC Euribia
MSC Euribia3 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy
2026 Sails: Oct 24, More...
MSC Cruises, MSC Grandiosa
MSC Grandiosa7 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, La Spezia (Cinque Terre), Italy, Civitavecchia (Rome), Italy, Palma De Mallorca (Balearic Islands), Spain, Barcelona, Spain
2026 Sails: Oct 24, More...
Ritz-Carlton, Evrima
Evrima7 Night - Barcelona / Lisbon
Starting in Barcelona, Palma de Mallorca, Mallorca, Balearic Islands, Ibiza, Balearic Islands, Cartagena ES, Malaga, Tangier, Lisbon
2026 Sails: Oct 24, More...
Viking Ocean, Viking Star
Viking Star7 Night - Iconic Western Mediterranean
Starting in Barcelona (Tarragona), Sete, Marseille, Monte Carlo, Florence / Pisa (Livorno), Rome (Civitavecchia)
2026 Sails: Oct 24, More...
AmaWaterways Tours, AmaDolce Tours
AmaDolce Tours14 Night - Taste of Bordeaux (Wine Cruise) with Madrid, San Sebastian Pre-Cruise and Paris Post Cruise
Starting in Madrid, San Sebastian, Bordeaux, Libourne, Blaye, Bourg, Cussac-Fort-Medoc, Cadillac, Bordeaux, Paris
2026 Sails: Oct 25, Nov 1, More...
AmaWaterways Tours, AmaDolce Tours
AmaDolce Tours14 Night - Taste of Bordeaux (Wine Cruise) with Madrid, San Sebastian Pre-Cruise and Loire Valley, Paris Charles De Gaulle Post-Cruise
Starting in Madrid, San Sebastian, Bordeaux, Libourne, Blaye, Bourg, Cussac-Fort-Medoc, Cadillac, Bordeaux, Loire Valley / Amboise, Aboisso, Paris
2026 Sails: Oct 25, Nov 1, More...
AmaWaterways Tours, AmaDolce Tours
AmaDolce Tours14 Night - Taste of Bordeaux (Wine Cruise) with Bilbao, San Sebastian Pre-Cruise and Paris Post Cruise
Starting in Bilbao, San Sebastian, Bordeaux, Libourne, Blaye, Bourg, Cussac-Fort-Medoc, Cadillac, Bordeaux, Paris
2026 Sails: Oct 25, Nov 1, Nov 8, More...

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Spain Cruise Departures