Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Cartagena ES : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Oceania Cruises, Oceania Allura

9 Night - Ramblas & the Rivieras
Starting in Barcelona, Provence (Marseille), Monte Carlo, Florence / Pisa / Tuscany (Livorno), Ajaccio (Corsica), Olbia / Porto Cervo (Sardinia), Palermo (Sicily), Valletta, Rome (Civitavecchia)
2026 Sails: Sep 5, More...

Silversea, Silver Ray

12 Night - Barcelona to Monte Carlo
Starting in Barcelona, Gibraltar, Malaga (Costa del Sol), Cartagena ES, Spain, Valencia, Alicante, Ibiza, Alcudia, Mallorca, Palamos, Monte Carlo
2026 Sails: Sep 5, More...

Costa Cruise Lines, Costa Toscana

7 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Cagliari, Napoli, Civitavecchia (Rome), Genoa (Portofino), Marseille, Barcelona
2026 Sails: Sep 6, Sep 13, Sep 20, Sep 27, Oct 4, Oct 11, Oct 18, Oct 25, Nov 1, More...

Celebrity Cruises, Celebrity Eclipse

11 Night - Italy, France & Greece Cruise
Starting in Barcelona, Spain, Nice (Villefranche), France, Florence / Pisa (La Spezia), Italy, Rome (Civitavecchia), Italy, Naples, Italy, Olympia (Katakolon), Greece, Ephesus (Kusadasi), Turkey, Santorini, Greece, Athens (Piraeus), Greece
2026 Sails: Sep 7, More...

Cunard Line, Queen Victoria

7 Night - Italy, France and Spain
Starting in Barcelona, Spain, Ibiza, Spain, Ajaccio, Corsica, France, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Salerno (tours to Capri or Pompeii), Italy, Amalfi Coast Sail By, IT, Civitavecchia (tours to Rome), Italy
2026 Sails: Sep 7, More...

Cunard Line, Queen Victoria

14 Night - Italy, France and Spain
Starting in Barcelona, Spain, Ibiza, Spain, Ajaccio, Corsica, France, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Salerno (tours to Capri or Pompeii), Italy, Amalfi Coast Sail By, IT, Civitavecchia (tours to Rome), Italy, Marseille, France, Villefranche, France, Genoa, Italy, La Spezia (tours to Florence or Pisa), Italy, Civitavecchia (tours to Rome), Italy
2026 Sails: Sep 7, More...

Cunard Line, Queen Victoria

28 Night - Istanbul, Greek Islands and Mediterranean
Starting in Barcelona, Spain, Ibiza, Spain, Ajaccio, Corsica, France, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Salerno (tours to Capri or Pompeii), Italy, Amalfi Coast Sail By, IT, Civitavecchia (tours to Rome), Italy, Marseille, France, Villefranche, France, Genoa, Italy, La Spezia (tours to Florence or Pisa), Italy, Civitavecchia (tours to Rome), Italy, Messina Strait, Italy (Transit), Rhodes, Greece, Kusadasi (tours to Ephesus), Turkey, Dardanelles Strait, Turkey (Transit), Istanbul, Turkey, Dardanelles Strait, Turkey (Transit), Piraeus (tours to Athens), Greece, Souda Bay (for Chania), Crete, Greece, Katakolon (tours to Olympia), Greece, Messina Strait, Italy (Transit), Civitavecchia (tours to Rome), Italy
2026 Sails: Sep 7, More...

Silversea, Silver Muse

7 Night - Barcelona to Civitavecchia
Starting in Barcelona, Palma De Mallorca, Cagliari (Sardinia), Tunis (La Goulette), Trapani, Sicily, Amalfi, Civitavecchia (Rome)
2026 Sails: Sep 7, More...

Windstar Tours, Star Legend Tours

12 Night - Yachtsman's Mediterranean Rivieras & Madrid Cruise Tour
Starting in Madrid, Spain, Barcelona, Palamos, Sanary-sur-mer, Monte Carlo, Cannes, Portofino, Portoferraio, Porto Ercole, Rome
2026 Sails: Sep 7, More...

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Palma De Mallorca
Starting in Palma De Mallorca, Valencia, Olbia, Civitavecchia (Rome), Savona, La Seyne (St Tropez), Palma De Mallorca
2026 Sails: Sep 8, More...

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