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Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Departing from
Spain
Cruise Specials

Silversea, Silver Ray
Silver Ray10 Night - Barcelona to Lisbon
Starting in Barcelona, Valencia, Cartagena ES, Spain, Malaga (Costa del Sol), Casablanca, Tangier, Cadiz, Lisbon
2026 Sails: Nov 18, More...
Celebrity Cruises, Celebrity Equinox
Celebrity Equinox16 Night - Spain to Argentina Transatlantic
Starting in Barcelona, Spain, Tangier, Morocco, Salvador De Bahia, Brazil, Rio De Janeiro, Brazil, Montevideo, Uruguay, Buenos Aires, Argentina
2026 Sails: Nov 19, More...
Costa Cruise Lines, Costa Smeralda
Costa Smeralda7 Night - Western Mediterranean from Las Palmas
Starting in Las Palmas (Gran Canaria), Funchal (Madeira), Santa Cruz de Tenerife, Port Rosario (Fuerteventura), Arrecife (Lanzarote), Las Palmas (Gran Canaria)
2026 Sails: Nov 19, Nov 26, More...
MSC Cruises, MSC Sinfonia
MSC Sinfonia6 Night - Mediterranean
Starting in Valencia, Spain, Palma De Mallorca (Balearic Islands), Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Livorno (Florence), Italy, Civitavecchia (Rome), Italy
2026 Sails: Nov 20, More...
Star Clippers, Star Clipper
Star Clipper15 Night - Westbound Atlantic Ocean Crossing
Starting in Las Palmas, Gran Canaria / Canary Islands, Spain, Santa Cruz de Tenerife, Bridgetown, Barbados
2026 Sails: Nov 20, More...
AmaWaterways, AmaVida
AmaVida7 Night - Flavors of Portugal & Spain (Taste of Christmas)
Starting in Vega de Terron, Barca dAlva, Pinhao, Regua, Entre-os-Rios, Porto
2026 Sails: Nov 21, Dec 5, Dec 19, 2027: Nov 20, Dec 4, 2028: Nov 4, Dec 2, More...
Sea Cloud, Sea Cloud II
Sea Cloud II17 Night - Transatlantic from Gran Canaria to Bridgetown
Starting in Las Palmas / Gran Canaria, Bridgetown
2026 Sails: Nov 21, More...
AmaWaterways Tours, AmaDolce Tours
AmaDolce Tours14 Night - Taste of Bordeaux (Taste of Christmas) with Bilbao, San Sebastian Pre-Cruise and Paris Post Cruise
Starting in Bilbao, San Sebastian, Bordeaux, Libourne, Blaye, Engelhartszell, Pauillac, Cadillac, Bordeaux
2026 Sails: Nov 22, Nov 29, More...
AmaWaterways Tours, AmaDolce Tours
AmaDolce Tours14 Night - Taste of Bordeaux (Taste of Christmas) with Bilbao, San Sebastian Pre-Cruise and Loire Valley, Paris Charles De Gaulle Post-Cruise
Starting in Bilbao, San Sebastian, Bordeaux, Libourne, Blaye, Engelhartszell, Pauillac, Cadillac, Bordeaux, Loire Valley / Amboise, Amboise, Paris
2026 Sails: Nov 22, More...
Costa Cruise Lines, Costa Smeralda
Costa Smeralda7 Night - Western Mediterranean from S. Cruz De Tenerife
Starting in Santa Cruz de Tenerife, Port Rosario (Fuerteventura), Arrecife (Lanzarote), Las Palmas (Gran Canaria), Funchal (Madeira), Santa Cruz de Tenerife
2026 Sails: Nov 22, More...

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Spain Cruise Departures