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Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Departing from
Spain
Cruise Specials

Silversea, Silver Ray
Silver Ray10 Night - Barcelona to Civitavecchia
Starting in Barcelona, Palma De Mallorca, Marseille, Monte Carlo, Portofino, Livorno (Tuscany), Salerno, Civitavecchia (Rome)
2026 Sails: May 19, More...
Costa Cruise Lines, Costa Pacifica
Costa Pacifica7 Night - Western Mediterranean from Valencia
Starting in Valencia, Olbia, Civitavecchia, Savona, Toulon / La Seyne-sur-Mer, Palma De Mallorca, Valencia
2026 Sails: May 20, Jul 8, Jul 15, Jul 22, Jul 29, Aug 5, More...
Explora Journeys, EXPLORA I
EXPLORA I7 Night - A Journey of Bewitching Scenery & Cultural Treasures
Starting in Barcelona, Marseille, Porto Cervo (Sardinia), Portofino, Livorno (Florence), Villefranche-Sur-Mer (Nice), Barcelona
2026 Sails: May 20, More...
Explora Journeys, EXPLORA I
EXPLORA I14 Night - An Extended Journey of Cultural Treasures and Glittering Shorelines
Starting in Barcelona, Marseille, Porto Cervo (Sardinia), Portofino, Livorno (Florence), Villefranche-Sur-Mer (Nice), Barcelona, Mahon (Menorca), Alghero (Sardinia), Cannes, Saint-Tropez, Civitavecchia (Rome), Monte Carlo
2026 Sails: May 20, More...
MSC Cruises, MSC Opera
MSC Opera10 Night - Mediterranean
Starting in Alicante, Spain, Mahon, Spain, Olbia, Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Malaga (Granada), Spain, Cadiz (Seville), Spain, Lisbon (Cascais), Portugal, Alicante, Spain
2026 Sails: May 20, May 30, Jun 9, Jun 19, Jul 9, Jul 29, Aug 8, Aug 18, Aug 28, Sep 7, Sep 17, Sep 27, More...
Viking Ocean, Viking Jupiter
Viking Jupiter14 Night - Trade Routes of the Middle Ages
Starting in Barcelona, Tarragona, Murcia (Cartagena ES, Spain), Granada (Malaga), Sail the Atlantic Ocean, Porto (Leixoes), Sail the Atlantic Ocean, Falmouth, Portsmouth UK, Paris (Le Havre), Bruges (Zeebrugge), Amsterdam, Sail the North Sea, Bergen
2026 Sails: May 20, More...
Azamara Journey5 Night - Spain Intensive Cruise : Barcelona, Ibiza & Majorca
Starting in Barcelona, Provence (Toulon), Mahon, Menorca, Ibiza, Spain, Palma, Majorca, Ibiza, Spain, Barcelona
2026 Sails: May 21, More...
Regent Seven Seas, Seven Seas Voyager
Seven Seas Voyager12 Night - Eastern Mediterranean Gems
Starting in Barcelona, Cruising the Mediterranean Sea, Messina (Sicily), Cruising the Ionian Sea, Dubrovnik, Croatia, Kotor, Corfu, Gythion, Rhodes, Cruising Aegean Sea, Santorini, Mykonos, Athens (Piraeus)
2026 Sails: May 21, More...
Royal Caribbean, Harmony of the Seas
Harmony of the Seas3 Night - Spain & France Cruise
Starting in Barcelona, Spain, Palma De Mallorca, Spain, Provence (Marseille), France, Barcelona, Spain
2026 Sails: May 21, More...
Celebrity Cruises, Celebrity Xcel
Celebrity Xcel10 Night - Italy & French Riviera
Starting in Barcelona, Spain, Naples, Italy, Sicily (Messina), Italy, Rome (Civitavecchia), Italy, Portofino, Italy, Florence / Pisa (La Spezia), Italy, Nice (Villefranche), France, Barcelona, Spain
2026 Sails: May 22, Oct 2, More...

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Spain Cruise Departures