Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Cartagena ES : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Norwegian Line Tours, Norwegian Sky Tours

12 Night - Explore Barcelona Pre Cruisetour
Starting in At Hotel, Barcelona, Spain, Nice / Monaco (Villefranche), France, Livorno / Florence / Pisa, Italy, Civitavecchia Rome, Italy, Amalfi Coast (Salerno), Italy, Santorini Island, Greece, Mykonos, Greece, Heraklion / Crete, Greece, Piraeus / Athens, Greece
2026 Sails: Aug 28, More...

Princess Cruises, Sun Princess

21 Night - The Best of the Mediterranean
Starting in Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece, Santorini, Greece, Montenegro, Corfu, Greece, Sicily (Messina), Italy, Barcelona, Spain
2026 Sails: Aug 29, 2027: Apr 11, More...

Silversea, Silver Muse

9 Night - Barcelona to Barcelona
Starting in Barcelona, Marseille, Monte Carlo, Porto Mahon, Palma De Mallorca, Ibiza, Alicante, Valencia, Barcelona
2026 Sails: Aug 29, More...

Oceania Cruises, Oceania Nautica

14 Night - Iberia Celebration
Starting in Bilbao, La Coruna, Santiago De Compostela (Vigo), Lisbon, Portimao, Seville, Seville (Cadiz), Alicante, Barcelona, Mahon (Menorca), Saint-Tropez, Florence / Pisa / Tuscany (Livorno), Rome (Civitavecchia)
2026 Sails: Aug 30, More...

Royal Caribbean, Legend of the Seas

Deal link -> Special

7 Night - Western Mediterranean Cruise
Starting in Barcelona, Spain, Palma De Mallorca, Spain, Provence (Marseille), France, Florence / Pisa (La Spezia), Italy, Rome (Civitavecchia), Italy, Naples, Italy, Barcelona, Spain
2026 Sails: Aug 30, Sep 6, Sep 13, Sep 20, Sep 27, Oct 4, Oct 11, Oct 18, More...

Explora Journeys, EXPLORA I

Deal link -> Special

14 Night - An Extended Journey Through Timeless Coastal Beauty & Cultural Splendour
Starting in Barcelona, Ibiza, Tunis / La Goulette, La Valletta, Giardini Naxos, Sorrento, Civitavecchia (Rome), Porto Santo Stefano (Argentario), Monte Carlo, Cannes, Valencia, Palma De Mallorca, Barcelona
2026 Sails: Aug 31, More...

Norwegian Cruise Line, Norwegian Sky

9 Night - Greek Isles, Italy, & France : European Jewels
Starting in Barcelona, Spain, Nice / Monaco (Villefranche), France, Livorno / Florence / Pisa, Italy, Civitavecchia Rome, Italy, Amalfi Coast (Salerno), Italy, Santorini Island, Greece, Mykonos, Greece, Heraklion / Crete, Greece, Piraeus / Athens, Greece
2026 Sails: Aug 31, More...

Regent Seven Seas, Seven Seas Navigator

10 Night - Extravagant Ionian Journey
Starting in Barcelona, Cruising the Ionian Sea, Tuscany (Livorno), Rome (Civitavecchia), Naples / Pompeii, Valletta, Cruising the Ionian Sea, Dubrovnik, Croatia, Split, Koper, Venice (Fusina)
2026 Sails: Sep 2, More...

Celebrity Cruises, Celebrity Equinox

9 Night - Spain, Portugal & Morocco
Starting in Barcelona, Spain, Seville (Cadiz), Spain, Porto (Leixoes), Portugal, Lisbon, Portugal, Tangier, Morocco, Barcelona, Spain
2026 Sails: Sep 3, More...

Celebrity Cruises, Celebrity Xcel

8 Night - Greece, Malta & Turkey Cruise
Starting in Barcelona, Spain, Valletta, Malta, Ephesus (Kusadasi), Turkey, Rhodes, Greece, Santorini, Greece, Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: Sep 5, More...

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