Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron : Vigo

MSC Cruises, MSC Seaview

7 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Palermo (Monreale), Italy, Ibiza (Balearic Islands), Spain, Barcelona, Spain
2026 Sails: May 7, May 14, May 21, May 28, Jun 4, Jun 11, Jun 18, Jun 25, Jul 2, Jul 9, Jul 16, Jul 23, Jul 30, Aug 6, Aug 13, Aug 20, Aug 27, Sep 3, Sep 10, Sep 17, Sep 24, Oct 1, Oct 8, Oct 15, More...

Norwegian Line Tours, Norwegian Dawn Tours

10 Night - Explore Barcelona Pre Cruisetour
Starting in At Hotel, Barcelona, Spain, Palma Majorca, Spain, Valencia, Spain, Motril, Spain, Gibraltar, Cadiz / Seville, Spain, Portimao, Portugal, Lisbon, Portugal
2026 Sails: May 7, May 21, Jul 2, Jul 16, Jul 30, Aug 13, More...

Royal Caribbean, Explorer of the Seas

9 Night - Italy, France & Croatia Cruise
Starting in Barcelona, Spain, Nice (Villefranche), France, Florence / Pisa (La Spezia), Italy, Rome (Civitavecchia), Italy, Dubrovnik, Croatia, Kotor, Montenegro, Zadar, Croatia, Ravenna, Italy
2026 Sails: May 7, More...

Costa Cruise Lines, Costa Fascinosa

4 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Marseille, Savona, Barcelona
2026 Sails: May 8, Oct 23, More...

MSC Cruises, MSC Grandiosa

7 Night - Mediterranean
Starting in Palma De Mallorca (Balearic Islands), Spain, Barcelona, Spain, Cannes (Cote Dazur), France, Genoa (Portofino), Italy, La Spezia (Cinque Terre), Italy, Civitavecchia (Rome), Italy, Palma De Mallorca (Balearic Islands), Spain
2026 Sails: May 8, May 15, May 22, May 29, Jun 5, Jun 12, Jun 19, Jun 26, Jul 3, Jul 10, Jul 17, Jul 24, Jul 31, Aug 7, Aug 14, Aug 21, Aug 28, Sep 4, Sep 11, Sep 18, Sep 25, Oct 2, Oct 9, Oct 16, More...

Silversea, Silver Ray

11 Night - Barcelona to Barcelona
Starting in Barcelona, Marseille, Palma De Mallorca, Ibiza, Gibraltar, Malaga (Costa del Sol), Cartagena ES, Spain, Valencia, Barcelona
2026 Sails: May 8, More...

SeaDream Yacht Club, SeaDream I

7 Night - Western Mediterranean Delight Cruise
Starting in Barcelona, Roses, Costa Brava, Sete, Saint-Cyr-sur-Mer, Sanary-sur-mer, St Tropez, Cannes, Nice
2026 Sails: May 9, More...

Princess Tours, Sun Princess Tours

13 Night - Highlights of Spain - Tour 2A
Starting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Santa Margherita, Italy, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy
2026 Sails: May 10, Jul 12, More...

Virgin Voyages, Scarlet Lady

7 Night - Rome, Mykonos & the Amalfi Coast
Starting in Barcelona, Spain, Civitavecchia (Rome), Italy, Amalfi Coast (Salerno), Italy, Catania, Sicily, Italy, Mykonos, Greece, Piraeus (Athens), Greece
2026 Sails: May 10, More...

Celebrity Cruises, Celebrity Xcel

11 Night - Spain, Portugal & Morocco
Starting in Barcelona, Spain, Seville (Cadiz), Spain, Lisbon, Portugal, Madeira (Funchal), Portugal, Tangier, Morocco, Palma De Mallorca, Spain, Barcelona, Spain
2026 Sails: May 11, Sep 21, Oct 12, More...

<= Back

More =>