Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Cartagena ES : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Costa Cruise Lines, Costa Toscana

7 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Cagliari, Napoli, Civitavecchia (Rome), Genoa (Portofino), Marseille, Barcelona
2026 Sails: Aug 16, Aug 23, Aug 30, More...

Norwegian Cruise Line, Norwegian Dawn

7 Night - Europe - Western Mediterranean - Barcelona
Starting in Barcelona, Spain, Palma Majorca, Spain, Valencia, Spain, Motril, Spain, Gibraltar, Tangier, Morocco, Cadiz / Seville, Spain, Lisbon, Portugal
2026 Sails: Aug 16, More...

Norwegian Line Tours, Norwegian Viva Tours

12 Night - Explore Barcelona Pre Cruisetour
Starting in At Hotel, Barcelona, Spain, Nice / Monaco (Villefranche), France, Livorno / Florence / Pisa, Italy, Civitavecchia Rome, Italy, Amalfi Coast (Salerno), Italy, Messina, Italy, Corfu, Greece, Kotor, Montenegro, Split, Croatia, Venice (Ravenna), Italy
2026 Sails: Aug 16, More...

Cunard Line, Queen Victoria

7 Night - Italy and Spain
Starting in Barcelona, Spain, Ibiza, Spain, Cagliari, Sardinia, Italy, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Salerno (tours to Capri or Pompeii), Italy, Amalfi Coast Sail By, IT, Civitavecchia (tours to Rome), Italy
2026 Sails: Aug 17, More...

Cunard Line, Queen Victoria

21 Night - Italy, Spain and Adriatic
Starting in Barcelona, Spain, Ibiza, Spain, Cagliari, Sardinia, Italy, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Salerno (tours to Capri or Pompeii), Italy, Amalfi Coast Sail By, IT, Civitavecchia (tours to Rome), Italy, Messina Strait, Italy (Transit), Cephalonia, Greece, Corfu, Greece, Kotor, Montenegro, Split, Croatia, Trieste, Italy, Zadar, Croatia, Dubrovnik, Croatia, Valletta, Malta, Palma De Mallorca, Spain, Barcelona, Spain
2026 Sails: Aug 17, More...

Cunard Line, Queen Victoria

14 Night - Italy, Spain and Adriatic
Starting in Barcelona, Spain, Ibiza, Spain, Cagliari, Sardinia, Italy, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Salerno (tours to Capri or Pompeii), Italy, Amalfi Coast Sail By, IT, Civitavecchia (tours to Rome), Italy, Messina Strait, Italy (Transit), Cephalonia, Greece, Corfu, Greece, Kotor, Montenegro, Split, Croatia, Trieste, Italy
2026 Sails: Aug 17, More...

Oceania Cruises, Oceania Sirena

10 Night - Visions of Byzantium
Starting in Barcelona, Palermo (Sicily), Syracuse IT (Sicily), Argostoli (Cephalonia), Gythion, Paros, Athens (Piraeus), Ephesus (Kusadasi), Bozcaada (Troy), Istanbul
2026 Sails: Aug 17, More...

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Palma De Mallorca
Starting in Palma De Mallorca, Valencia, Olbia, Civitavecchia (Rome), Savona, La Seyne (St Tropez), Palma De Mallorca
2026 Sails: Aug 18, Aug 25, Sep 1, More...

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Valencia
Starting in Valencia, Olbia, Civitavecchia (Rome), Savona, La Seyne (St Tropez), Palma De Mallorca, Valencia
2026 Sails: Aug 19, Aug 26, Sep 2, More...

Norwegian Line Tours, Norwegian Epic Tours

10 Night - Explore Barcelona Pre Cruisetour
Starting in At Hotel, Barcelona, Spain, Provence, Marseille, France, Cannes, France, Livorno / Florence / Pisa, Italy, Messina, Italy, Amalfi Coast (Salerno), Italy, Civitavecchia Rome, Italy
2026 Sails: Aug 20, More...

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