Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron : Vigo

MSC Cruises, MSC Meraviglia

4 Night - Mediterranean
Starting in Barcelona, Spain, La Goulette, Tunisia, Palermo (Monreale), Italy, Naples (Pompeii), Italy
2026 Sails: May 5, More...

MSC Cruises, MSC Meraviglia

5 Night - Mediterranean
Starting in Barcelona, Spain, La Goulette, Tunisia, Palermo (Monreale), Italy, Naples (Pompeii), Italy, Livorno (Florence), Italy
2026 Sails: May 5, More...

MSC Cruises, MSC Meraviglia

Deal link -> Special

6 Night - Mediterranean
Starting in Barcelona, Spain, La Goulette, Tunisia, Palermo (Monreale), Italy, Naples (Pompeii), Italy, Livorno (Florence), Italy, Marseille (Provence), France
2026 Sails: May 5, More...

Oceania Cruises, Oceania Sirena

7 Night - Yachting Havens
Starting in Barcelona, Palamos, Provence (Marseille), Cannes, Saint-Tropez, Florence / Pisa / Tuscany (Livorno), Piombino (Tuscany), Rome (Civitavecchia)
2026 Sails: May 5, More...

PONANT, Le Boreal

9 Night - Ancient Shores of the Mediterranean
Starting in Malaga, Cartagena, Oran, Algiers, Tunis, Palermo, Sicily, Trapani, Sicily, Palermo, Sicily, Syracuse, Sicily, Valletta
2026 Sails: May 5, More...

Costa Cruise Lines, Costa Favolosa

11 Night - Transatlantic from Barcelona
Starting in Barcelona, Malaga, Cadice, Lisbon, Leixoes, La Coruna, Le Havre, Dover UK, Hamburg
2026 Sails: May 6, More...

Emerald Cruises, Emerald Radiance

10 Night - Madrid & Secrets of the Douro
Starting in Madrid, Madrid / Porto, Porto / Pinhao, Pinhao / Vega de Terron, Vega de Terron / Salamanca, Pocinho / Regua, Regua, Porto
2026 Sails: May 6, 2027: Apr 7, May 19, Jun 30, Nov 3, More...

Emerald Cruises, Emerald Radiance

13 Night - Madrid to Lisbon & Secrets of the Douro
Starting in Madrid, Madrid / Porto, Porto / Pinhao, Pinhao / Vega de Terron, Vega de Terron / Salamanca, Pocinho / Regua, Regua, Porto, Porto / Lisbon, Lisbon
2026 Sails: May 6, 2027: Apr 7, May 19, Jun 30, Nov 3, More...

MSC Cruises, MSC Opera

10 Night - Mediterranean
Starting in Malaga (Granada), Spain, Gibraltar, Lisbon (Cascais), Portugal, Alicante, Spain, Mahon, Spain, Olbia, Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Malaga (Granada), Spain
2026 Sails: May 6, More...

PONANT, Le Champlain

11 Night - Heavenly Islands & Iberian Shores
Starting in Barcelona, Mahon, Balearic Islands, Ibiza, Balearic Islands, Valencia, Cartagena, Motril, Malaga, Cadiz, Portimao, Lisbon, Figueira da Foz, Leixoes / Porto
2026 Sails: May 6, More...

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