Spain Cruise Departures
Cruises that depart from Europe: Spain
Cruises that visit Spain
See all River Cruises that depart from Spain
Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron : Vigo
17 Night - An Extended Journey Through Architectural Wonders & Spectacular Landscapes
Starting in Barcelona, Cadiz, Tangier, Motril, Cartagena ES, Saint-Tropez, Monte Carlo, Livorno (Florence), Civitavecchia (Rome), Sorrento, Palermo (Sicily), Tunis / La Goulette, Ibiza, Mahon (Menorca), Barcelona
2026 Sails: May 3, More...10 Night - A Journey of Unique Architecture Seamlessely Blending Culture & Scenic Beauty
Starting in Barcelona, Cadiz, Tangier, Motril, Cartagena ES, Saint-Tropez, Monte Carlo, Livorno (Florence), Civitavecchia (Rome)
2026 Sails: May 3, More...
7 Night - Europe - Western Mediterranean - Barcelona
Starting in Barcelona, Spain, Provence, Marseille, France, Nice / Monaco (Villefranche), France, Livorno / Florence / Pisa, Italy, Messina, Italy, Amalfi Coast (Salerno), Italy, Civitavecchia Rome, Italy
2026 Sails: May 3, May 31, Jun 14, Jun 28, Jul 12, Jul 26, Aug 9, Oct 4, Oct 18, More...
8 Night - Barcelona / Rome (Civitavecchia)
Starting in Barcelona, Palma de Mallorca, Mallorca, Balearic Islands, Saint-Tropez, Cannes, Monte Carlo, Portofino, Livorno, Rome (Civitavecchia)
2026 Sails: May 3, More...
12 Night - Jewels of Spain and Morocco
Starting in Santa Cruz de Tenerife, Canary Islands, Spain, Santa Cruz de la Palma, Canary Islands, Spain, Arrecife, Lanzarote, Canary Islands, Spain, Casablanca, Morocco, Tangier, Morocco, Seville, Spain, Puerto Banus (Marbella), Spain, Oran, Algeria, Ibiza, Spain, Palma De Mallorca, Spain, Barcelona, Spain
2026 Sails: May 3, More...
7 Night - Mediterranean and Greek Islands
Starting in Barcelona, Spain, Heraklion, Crete, Greece, Kusadasi (tours to Ephesus), Turkey, Dardanelles Strait, Turkey (Transit), Istanbul, Turkey
2026 Sails: May 4, More...21 Night - Mediterranean and Greek Islands
Starting in Barcelona, Spain, Heraklion, Crete, Greece, Kusadasi (tours to Ephesus), Turkey, Dardanelles Strait, Turkey (Transit), Istanbul, Turkey, Dardanelles Strait, Turkey (Transit), Piraeus (tours to Athens), Greece, Mykonos, Greece, Katakolon (tours to Olympia), Greece, Messina Strait, Italy (Transit), Barcelona, Spain, La Seyne-sur-Mer (for Toulon), France, Livorno (tours to Florence or Pisa), Italy, Ibiza, Spain, Valencia, Spain, Barcelona, Spain
2026 Sails: May 4, More...14 Night - Mediterranean and Greek Islands
Starting in Barcelona, Spain, Heraklion, Crete, Greece, Kusadasi (tours to Ephesus), Turkey, Dardanelles Strait, Turkey (Transit), Istanbul, Turkey, Dardanelles Strait, Turkey (Transit), Piraeus (tours to Athens), Greece, Mykonos, Greece, Katakolon (tours to Olympia), Greece, Messina Strait, Italy (Transit), Barcelona, Spain
2026 Sails: May 4, More...28 Night - Mediterranean and Greek Islands
Starting in Barcelona, Spain, Heraklion, Crete, Greece, Kusadasi (tours to Ephesus), Turkey, Dardanelles Strait, Turkey (Transit), Istanbul, Turkey, Dardanelles Strait, Turkey (Transit), Piraeus (tours to Athens), Greece, Mykonos, Greece, Katakolon (tours to Olympia), Greece, Messina Strait, Italy (Transit), Barcelona, Spain, La Seyne-sur-Mer (for Toulon), France, Livorno (tours to Florence or Pisa), Italy, Ibiza, Spain, Valencia, Spain, Barcelona, Spain, Palma De Mallorca, Spain, Ajaccio, Corsica, France, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Salerno (tours to Capri or Pompeii), Italy, Amalfi Coast Sail By, IT, Civitavecchia (tours to Rome), Italy
2026 Sails: May 4, More...
7 Night - Mediterranean
Starting in Barcelona, Spain, La Goulette, Tunisia, Palermo (Monreale), Italy, Naples (Pompeii), Italy, Livorno (Florence), Italy, Marseille (Provence), France, Barcelona, Spain
2026 Sails: May 5, May 12, May 19, May 26, Jun 2, Jun 9, Jun 16, Jun 23, Jun 30, Jul 7, Jul 14, Jul 21, Jul 28, Aug 4, Aug 11, Aug 18, Aug 25, Sep 1, Sep 8, Sep 15, Sep 22, Sep 29, Oct 6, Oct 13, More...
Cruises that depart from Europe: Spain
Cruises that visit Spain
See all River Cruises that depart from Spain
Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.
Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron : Vigo
17 Night - An Extended Journey Through Architectural Wonders & Spectacular LandscapesStarting in Barcelona, Cadiz, Tangier, Motril, Cartagena ES, Saint-Tropez, Monte Carlo, Livorno (Florence), Civitavecchia (Rome), Sorrento, Palermo (Sicily), Tunis / La Goulette, Ibiza, Mahon (Menorca), Barcelona
2026 Sails: May 3, More...
Deal link -> Special
10 Night - A Journey of Unique Architecture Seamlessely Blending Culture & Scenic BeautyStarting in Barcelona, Cadiz, Tangier, Motril, Cartagena ES, Saint-Tropez, Monte Carlo, Livorno (Florence), Civitavecchia (Rome)
2026 Sails: May 3, More...
7 Night - Europe - Western Mediterranean - BarcelonaStarting in Barcelona, Spain, Provence, Marseille, France, Nice / Monaco (Villefranche), France, Livorno / Florence / Pisa, Italy, Messina, Italy, Amalfi Coast (Salerno), Italy, Civitavecchia Rome, Italy
2026 Sails: May 3, May 31, Jun 14, Jun 28, Jul 12, Jul 26, Aug 9, Oct 4, Oct 18, More...
8 Night - Barcelona / Rome (Civitavecchia)Starting in Barcelona, Palma de Mallorca, Mallorca, Balearic Islands, Saint-Tropez, Cannes, Monte Carlo, Portofino, Livorno, Rome (Civitavecchia)
2026 Sails: May 3, More...
12 Night - Jewels of Spain and MoroccoStarting in Santa Cruz de Tenerife, Canary Islands, Spain, Santa Cruz de la Palma, Canary Islands, Spain, Arrecife, Lanzarote, Canary Islands, Spain, Casablanca, Morocco, Tangier, Morocco, Seville, Spain, Puerto Banus (Marbella), Spain, Oran, Algeria, Ibiza, Spain, Palma De Mallorca, Spain, Barcelona, Spain
2026 Sails: May 3, More...
7 Night - Mediterranean and Greek IslandsStarting in Barcelona, Spain, Heraklion, Crete, Greece, Kusadasi (tours to Ephesus), Turkey, Dardanelles Strait, Turkey (Transit), Istanbul, Turkey
2026 Sails: May 4, More...
21 Night - Mediterranean and Greek IslandsStarting in Barcelona, Spain, Heraklion, Crete, Greece, Kusadasi (tours to Ephesus), Turkey, Dardanelles Strait, Turkey (Transit), Istanbul, Turkey, Dardanelles Strait, Turkey (Transit), Piraeus (tours to Athens), Greece, Mykonos, Greece, Katakolon (tours to Olympia), Greece, Messina Strait, Italy (Transit), Barcelona, Spain, La Seyne-sur-Mer (for Toulon), France, Livorno (tours to Florence or Pisa), Italy, Ibiza, Spain, Valencia, Spain, Barcelona, Spain
2026 Sails: May 4, More...
14 Night - Mediterranean and Greek IslandsStarting in Barcelona, Spain, Heraklion, Crete, Greece, Kusadasi (tours to Ephesus), Turkey, Dardanelles Strait, Turkey (Transit), Istanbul, Turkey, Dardanelles Strait, Turkey (Transit), Piraeus (tours to Athens), Greece, Mykonos, Greece, Katakolon (tours to Olympia), Greece, Messina Strait, Italy (Transit), Barcelona, Spain
2026 Sails: May 4, More...
28 Night - Mediterranean and Greek IslandsStarting in Barcelona, Spain, Heraklion, Crete, Greece, Kusadasi (tours to Ephesus), Turkey, Dardanelles Strait, Turkey (Transit), Istanbul, Turkey, Dardanelles Strait, Turkey (Transit), Piraeus (tours to Athens), Greece, Mykonos, Greece, Katakolon (tours to Olympia), Greece, Messina Strait, Italy (Transit), Barcelona, Spain, La Seyne-sur-Mer (for Toulon), France, Livorno (tours to Florence or Pisa), Italy, Ibiza, Spain, Valencia, Spain, Barcelona, Spain, Palma De Mallorca, Spain, Ajaccio, Corsica, France, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Salerno (tours to Capri or Pompeii), Italy, Amalfi Coast Sail By, IT, Civitavecchia (tours to Rome), Italy
2026 Sails: May 4, More...
7 Night - MediterraneanStarting in Barcelona, Spain, La Goulette, Tunisia, Palermo (Monreale), Italy, Naples (Pompeii), Italy, Livorno (Florence), Italy, Marseille (Provence), France, Barcelona, Spain
2026 Sails: May 5, May 12, May 19, May 26, Jun 2, Jun 9, Jun 16, Jun 23, Jun 30, Jul 7, Jul 14, Jul 21, Jul 28, Aug 4, Aug 11, Aug 18, Aug 25, Sep 1, Sep 8, Sep 15, Sep 22, Sep 29, Oct 6, Oct 13, More...
