Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Costa Cruise Lines, Costa Diadema

13 Night - Mediterranean Roundtrip from Cadiz
Starting in Cadiz, Spain, Lisbon, Portugal, Gibraltar (UK), Malaga, Spain, Cartagena ES, Spain, Marseilles, France, Savona, Italy, Barcelona, Spain, Tangier, Morocco, Casablanca, Morocco, Cadiz, Spain
2026 Sails: Sep 30, More...

Costa Cruise Lines, Costa Pacifica

6 Night - Western Mediterranean from Valencia
Starting in Valencia, Olbia (costa Smeralda), Civitavecchia (Rome), Savona, Marseille, Barcelona
2026 Sails: Sep 30, More...

Oceania Cruises, Oceania Sirena

Deal link -> Special

12 Night - French & Italian Treasures
Starting in Barcelona, Palamos, Toulon, Saint-Tropez, Cinque Terre (La Spezia), Ajaccio (Corsica), Cagliari (Sardinia), Trapani (Sicily), Valletta, Messina (Sicily), Sorrento / Capri, Porto Ercole, Rome (Civitavecchia)
2026 Sails: Sep 30, More...

Celebrity Cruises, Celebrity Equinox

9 Night - Spain, Portugal & Morocco
Starting in Barcelona, Spain, Lisbon, Portugal, Porto (Leixoes), Portugal, Seville (Cadiz), Spain, Tangier, Morocco, Barcelona, Spain
2026 Sails: Oct 1, More...

Norwegian Line Tours, Norwegian Dawn Tours

10 Night - Explore Barcelona Pre Cruisetour
Starting in At Hotel, Barcelona (Tarragona), Spain, Cadiz / Seville, Spain, Motril, Spain, Gibraltar, Ibiza, Spain, Palma Majorca, Spain, Barcelona, Spain
2026 Sails: Oct 1, More...

Norwegian Line Tours, Norwegian Epic Tours

10 Night - Explore Barcelona Pre Cruisetour
Starting in At Hotel, Barcelona, Spain, Provence, Marseille, France, Nice / Monaco (Villefranche), France, Livorno / Florence / Pisa, Italy, Messina, Italy, Amalfi Coast (Salerno), Italy, Civitavecchia Rome, Italy
2026 Sails: Oct 1, Oct 15, More...

Celebrity Cruises, Celebrity Xcel

10 Night - Italy & French Riviera
Starting in Barcelona, Spain, Naples, Italy, Sicily (Messina), Italy, Rome (Civitavecchia), Italy, Portofino, Italy, Florence / Pisa (La Spezia), Italy, Nice (Villefranche), France, Barcelona, Spain
2026 Sails: Oct 2, More...

Oceania Cruises, Oceania Marina

9 Night - Around Iberia
Starting in Bilbao, La Coruna, Oporto, Lisbon, Portimao, Gibraltar, Seville (Cadiz), Malaga, Alicante, Barcelona (Tarragona)
2026 Sails: Oct 2, More...

MSC Cruises, MSC Opera

7 Night - Mediterranean
Starting in Malaga (Granada), Spain, Cadiz (Seville), Spain, Lisbon (Cascais), Portugal, Alicante, Spain, Mahon, Spain, Olbia, Italy, Genoa (Portofino), Italy
2026 Sails: Oct 3, More...

Scenic Luxury, Scenic Eclipse II

11 Night - Iberian Discovery : Spain and Portugal with Morocco
Starting in Barcelona, Spain, Palma De Mallorca, Spain, Ibiza, Spain, Cartagena ES, Malaga, Spain, Puerto Banus (Marbella), Spain, Gibraltar, United Kingdom / Transit Strait of Gibraltar, Tangier, Morocco, Seville, Spain, Portimao, Portugal, Lisbon, Portugal
2026 Sails: Oct 3, More...

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