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Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Departing from
Spain
Cruise Specials

MSC Cruises, MSC Seaview
MSC Seaview7 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Palermo (Monreale), Italy, Ibiza (Balearic Islands), Spain, Tarragona, Spain
2026 Sails: Nov 5, More...
Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa10 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Gibraltar, Tangier, Casablanca, Cadiz, Malaga, Marseille, Savona, Barcelona
2026 Sails: Nov 6, More...
MSC Cruises, MSC Sinfonia
MSC Sinfonia8 Night - Mediterranean
Starting in Valencia, Spain, Palma De Mallorca (Balearic Islands), Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Livorno (Florence), Italy, Civitavecchia (Rome), Italy, Valencia, Spain
2026 Sails: Nov 6, Nov 20, More...
MSC Cruises, MSC World Europa
MSC World Europa6 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Messina (Taormina), Italy, Barcelona, Spain
2026 Sails: Nov 6, More...
AmaWaterways, AmaVida
AmaVida7 Night - Flavors of Portugal & Spain
Starting in Vega de Terron, Barca dAlva, Pinhao, Regua, Entre-os-Rios, Porto
2026 Sails: Nov 7, 2027: Mar 27, Nov 6, 2028: Mar 25, Apr 8, Nov 18, More...
PONANT, Le Dumont-d'Urville
Le Dumont-d'Urville8 Night - Atlantic Odyssey from the Iberian Peninsula to the Canary Islands
Starting in Malaga, Tangier, Casablanca, Funchal, Madeira, Arrecife de Lanzarote, Canary Islands, Santa Cruz de La Palma, Las Palmas de Gran Canaria, Canary Islands
2026 Sails: Nov 7, More...
Costa Cruise Lines, Costa Toscana
Costa Toscana7 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Palma De Mallorca, Naples, Civitavecchia (Rome), Genoa (Portofino), Marseille, Barcelona
2026 Sails: Nov 8, More...
MSC Cruises, MSC Sinfonia
MSC Sinfonia7 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Livorno (Florence), Italy, Civitavecchia (Rome), Italy, Valencia, Spain, Barcelona, Spain
2026 Sails: Nov 8, Nov 22, More...
Silversea, Silver Ray
Silver Ray10 Night - Barcelona to Barcelona
Starting in Barcelona, Marseille, Palma De Mallorca, Gibraltar, Malaga (Costa del Sol), Cartagena ES, Spain, Valencia, Barcelona
2026 Sails: Nov 8, More...
AmaWaterways Tours, AmaKristina Tours
AmaKristina Tours13 Night - Colors of Provence (Taste of Christmas) with Barcelona Pre-Cruise and Paris Post-Cruise
Starting in Barcelona, Arles, Avignon, Viviers, Tournon, Vienne, Lyon, Paris
2026 Sails: Nov 9, Dec 7, 2027: Oct 11, Nov 22, Dec 6, More...

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Spain Cruise Departures