Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

MSC Cruises, MSC Musica

7 Night - Mediterranean
Starting in Valencia, Spain, Ibiza (Balearic Islands), Spain, Cagliari (Sardinia), Italy, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Valencia, Spain
2026 Sails: Jul 30, Aug 13, Aug 20, Aug 27, Sep 3, More...

MSC Cruises, MSC Seaview

7 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Palermo (Monreale), Italy, Ibiza (Balearic Islands), Spain, Barcelona, Spain
2026 Sails: Jul 30, Aug 6, Aug 13, Aug 20, Aug 27, Sep 3, Sep 10, Sep 17, Sep 24, Oct 1, Oct 8, Oct 15, Oct 22, Oct 29, More...

MSC Cruises, MSC World Europa

7 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy, Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain
2026 Sails: Jul 31, Aug 7, Aug 14, Aug 21, Aug 28, Sep 4, Sep 11, Sep 18, Sep 25, Oct 2, Oct 9, Oct 16, Oct 23, Oct 30, More...

AmaWaterways, AmaVida

7 Night - Flavors of Portugal & Spain
Starting in Vega de Terron, Barca dAlva, Pinhao, Regua, Entre-os-Rios, Porto
2026 Sails: Aug 1, Nov 7, 2027: Mar 27, Nov 6, More...

Celebrity Cruises, Celebrity Xcel

7 Night - Italy & France Cruise
Starting in Barcelona, Spain, Provence (Marseille), France, Portofino, Italy, Florence / Pisa (La Spezia), Italy, Rome (Civitavecchia), Italy, Naples, Italy, Barcelona, Spain
2026 Sails: Aug 1, More...

MSC Cruises, MSC Grandiosa

7 Night - Mediterranean
Starting in Barcelona, Spain, Cannes (Cote Dazur), France, Genoa (Portofino), Italy, La Spezia (Cinque Terre), Italy, Civitavecchia (Rome), Italy, Palma De Mallorca (Balearic Islands), Spain, Barcelona, Spain
2026 Sails: Aug 1, Aug 8, Aug 15, Aug 22, Aug 29, Sep 5, Sep 12, Sep 19, Sep 26, Oct 3, Oct 10, Oct 17, More...

MSC Cruises, MSC Orchestra

7 Night - Mediterranean
Starting in Valencia, Spain, Livorno (Florence), Italy, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Tarragona, Spain, Valencia, Spain
2026 Sails: Aug 1, Aug 8, Aug 15, Aug 22, Aug 29, Sep 5, Sep 12, Sep 19, Sep 26, Oct 3, Oct 10, Oct 17, More...

AmaWaterways Tours, AmaDolce Tours

14 Night - Taste of Bordeaux (Wine Cruise) with Bilbao, San Sebastian Pre-Cruise and Paris Post Cruise
Starting in Bilbao, San Sebastian, Bordeaux, Libourne, Blaye, Engelhartszell, Cussac-Fort-Medoc, Cadillac, Bordeaux, Paris
2026 Sails: Aug 2, Aug 9, 2027: Mar 14, Mar 21, Mar 28, Apr 4, Jul 4, Jul 11, Jul 18, Aug 1, Aug 8, Aug 15, Sep 26, Nov 21, Nov 28, Dec 5, Dec 12, More...

AmaWaterways Tours, AmaDolce Tours

14 Night - Taste of Bordeaux (Wine Cruise) with Bilbao, San Sebastian Pre-Cruise and Loire Valley, Paris Charles De Gaulle Post-Cruise
Starting in Bilbao, San Sebastian, Bordeaux, Libourne, Blaye, Engelhartszell, Cussac-Fort-Medoc, Cadillac, Bordeaux, Loire Valley / Amboise, Amboise, Paris
2026 Sails: Aug 2, Aug 9, 2027: Mar 14, Mar 21, Mar 28, Apr 4, Jul 4, Jul 11, Jul 18, Aug 1, Aug 8, Aug 15, Sep 26, Nov 21, Nov 28, Dec 5, More...

Costa Cruise Lines, Costa Toscana

7 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Cagliari, Naples, Civitavecchia (Rome), Genoa (Portofino), Marseille, Barcelona
2026 Sails: Aug 2, Aug 9, More...

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