Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

MSC Cruises, MSC Seaview

7 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Palermo (Monreale), Italy, Ibiza (Balearic Islands), Spain, Barcelona, Spain
2026 Sails: Oct 29, More...

Norwegian Cruise Line, Norwegian Star

11 Night - Canary Islands / Morocco
Starting in Barcelona, Spain, Motril, Spain, Cadiz / Seville, Spain, Casablanca, Morocco, Agadir, Morocco, Arrecife, Spain, Santa Cruz de Tenerife, Funchal, Portugal, Oporto, Portugal, Lisbon, Portugal
2026 Sails: Oct 29, More...

Oceania Cruises, Oceania Sirena

7 Night - Costa Brava & Italy
Starting in Barcelona (Tarragona), Palamos, Provence (Marseille), Ajaccio (Corsica), Cinque Terre (La Spezia), Olbia / Porto Cervo (Sardinia), Naples / Pompeii, Rome (Civitavecchia)
2026 Sails: Oct 29, More...

Silversea, Silver Ray

10 Night - Barcelona to Barcelona
Starting in Barcelona, Marseille, Cannes, Palma De Mallorca, Malaga (Costa del Sol), Cartagena ES, Spain, Valencia, Barcelona
2026 Sails: Oct 29, More...

Celebrity Cruises, Celebrity Equinox

10 Night - Greece, Italy & Malta Cruise
Starting in Barcelona, Spain, Valletta, Malta, Chania (Souda), Crete, Greece, Olympia (Katakolon), Greece, Sicily (Messina), Italy, Naples, Italy, Rome (Civitavecchia), Italy, Barcelona, Spain
2026 Sails: Oct 30, Nov 9, More...

Costa Cruise Lines, Costa Fascinosa

4 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Marseille, Savona, Barcelona
2026 Sails: Oct 30, More...

MSC Cruises, MSC Grandiosa

15 Night - Msc Grand Voyages
Starting in Palma De Mallorca (Balearic Islands), Spain, Barcelona, Spain, Funchal (Madeira Islands), Portugal, San Juan, Puerto Rico, Miami, Florida, Port Canaveral (Orlando), Florida
2026 Sails: Oct 30, More...

MSC Cruises, MSC Grandiosa

1 Night - Mediterranean
Starting in Palma De Mallorca (Balearic Islands), Spain, Barcelona, Spain
2026 Sails: Oct 30, More...

MSC Cruises, MSC World Europa

7 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy, Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain
2026 Sails: Oct 30, More...

Windstar, Wind Surf

8 Night - Spanish Symphony
Starting in Barcelona, Palma De Mallorca, Cartagena ES, Almeria, Granada, Malaga, Gibraltar, Cadiz, Lisbon
2026 Sails: Oct 30, More...

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