Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

MSC Cruises, MSC Musica

7 Night - Canary Islands and Madeira
Starting in Las Palmas de Gran Canaria (Canary Islands), Spain, Funchal (Madeira Islands), Portugal, Santa Cruz de Tenerife, Arrecife De Lanzarote (Canary Islands), Spain, Puerto Del Rosario / Fuerteventura, Spain, Funchal (Madeira Islands), Portugal, Las Palmas de Gran Canaria (Canary Islands), Spain
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MSC Cruises, MSC World Europa

7 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain
2025 Sails: Dec 12, Dec 19, Dec 26, 2026: Jan 2, Jan 9, Jan 16, Jan 23, Jan 30, Feb 6, Feb 13, Feb 20, Feb 27, Mar 6, Mar 13, Mar 20, Mar 27, Apr 3, Apr 10, More...

Viking Ocean, Viking Sea

14 Night - West Indies to Iberia
Starting in Barcelona, Valencia, Sail the Alboran Sea, Seville (Cadiz), Casablanca, Sail the Atlantic Ocean, Philipsburg, St Kitts (Basseterre), San Juan
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AmaWaterways, AmaVida

Deal link -> Special

7 Night - Flavors of Portugal & Spain
Starting in Vega de Terron, Barca dAlva, Pinhao, Regua, Entre-os-Rios, Porto
2025 Sails: Dec 6, 2026: Dec 5, More...

MSC Cruises, MSC Orchestra

7 Night - Mediterranean
Starting in Valencia, Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Livorno (Florence), Italy, Civitavecchia (Rome), Italy, Valencia, Spain
2025 Sails: Dec 6, More...

MSC Cruises, MSC Splendida

7 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy, Palermo (Monreale), Italy, La Goulette, Tunisia, Barcelona, Spain
2025 Sails: Dec 6, Dec 13, Dec 20, Dec 27, 2026: Jan 3, Feb 7, Feb 14, Feb 21, Feb 28, Mar 7, Mar 14, Mar 21, Mar 28, Apr 4, Apr 11, Apr 18, More...

Norwegian Cruise Line (NCL), NCL Norwegian Sky

16 Night - Repo - Europe
Starting in Barcelona, Spain, Malaga / Granada, Spain, Cadiz / Seville, Spain, Casablanca, Morocco, Agadir, Morocco, Porto Grande, Cape Verde, Philipsburg, St Maarten, Netherland Antilles, Basseterre, Saint Kitts / Nevis, Tortola, British Virgin Islands, Punta Cana (La Romana), Dominican Republic
2025 Sails: Dec 6, More...

AmaWaterways Cruise Tours, AmaDolce Cruise Tours

11 Night - Taste of Bordeaux Christmas with Bilbao, San Sebastian Pre-Cruise
Starting in Bilbao, San Sebastian, Bordeaux, Libourne, Blaye, Bourg, Pauillac, Cadillac, Bordeaux
2025 Sails: Dec 7, More...

AmaWaterways Cruise Tours, AmaDolce Cruise Tours

14 Night - Taste of Bordeaux Christmas with Bilbao, San Sebastian Pre-Cruise and Paris Post Cruise
Starting in Bilbao, San Sebastian, Bordeaux, Libourne, Blaye, Bourg, Pauillac, Cadillac, Bordeaux
2025 Sails: Dec 7, 2026: Nov 22, Nov 29, Dec 13, More...

Costa Cruise Lines, Costa Toscana

7 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Napoli, Civitavecchia, La Spezia, Genoa, Marseille, Barcelona
2025 Sails: Dec 7, More...

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