Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Cartagena ES : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Costa Cruise Lines, Costa Fortuna

8 Night - Mediterranean from Barcelona to Athens (Piraeus)
Starting in Barcelona, Marseille, Savona, Civitavecchia (Rome), Messina (Taormina), Malta / La Valletta, Heraklion, Athens (Piraeus)
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Costa Cruise Lines, Costa Fortuna

2 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Marseille, Savona
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MSC Cruises, MSC Seaview

7 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Palermo (Monreale), Italy, Ibiza (Balearic Islands), Spain, Barcelona, Spain
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Ritz-Carlton, Evrima

6 Night - Barcelona / Rome (Civitavecchia)
Starting in Barcelona, Palma de Mallorca, Mallorca, Balearic Islands, Mahon, Menorca, Balearic Islands, Saint-Tropez, Monte Carlo, Portofino, Rome (Civitavecchia)
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Costa Cruise Lines, Costa Fascinosa

4 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Marseille, Savona, Barcelona
2026 Sails: May 1, Oct 13, Oct 30, More...

MSC Cruises, MSC Orchestra

7 Night - Mediterranean
Starting in Tarragona, Spain, Valencia, Spain, Livorno (Florence), Italy, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Tarragona, Spain
2026 Sails: May 1, May 8, May 15, May 22, Jun 5, Jun 12, Jun 19, Jun 26, Jul 3, Jul 10, Jul 17, Jul 24, Jul 31, Aug 7, Aug 14, Aug 21, Aug 28, Sep 4, Sep 11, Sep 18, Sep 25, Oct 2, Oct 9, Oct 16, More...

MSC Cruises, MSC Grandiosa

2 Night - Mediterranean
Starting in Barcelona, Spain, Cannes (Cote D Azur), France, Genoa (Portofino), Italy
2026 Sails: May 2, More...

MSC Cruises, MSC Grandiosa

1 Night - Mediterranean
Starting in Barcelona, Spain, Cannes (Cote D Azur), France
2026 Sails: May 2, More...

MSC Cruises, MSC Grandiosa

4 Night - Mediterranean
Starting in Barcelona, Spain, Cannes (Cote D Azur), France, Genoa (Portofino), Italy, La Spezia (Cinque Terre), Italy, Civitavecchia (Rome), Italy
2026 Sails: May 2, More...

MSC Cruises, MSC Orchestra

7 Night - Mediterranean
Starting in Valencia, Spain, Livorno (Florence), Italy, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Tarragona, Spain, Valencia, Spain
2026 Sails: May 2, May 9, May 16, May 23, May 30, Jun 6, Jun 13, Jun 20, Jun 27, Jul 4, Jul 11, Jul 18, Jul 25, Aug 1, Aug 8, Aug 15, Aug 22, Aug 29, Sep 5, Sep 12, Sep 19, Sep 26, Oct 3, Oct 10, More...

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