Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Costa Cruise Lines, Costa Fortuna

7 Night - Cruise Roundtrip from Las Palmas
Starting in Las Palmas, Canary Islands, Funchal (Madeira), Canary Sea Darkest Spot, Santa Cruz de Tenerife, Arrecife, Canary Islands, Atlantis Crest East, Agadir, Morocco, Fuerteventura, Canary Islands, Las Palmas, Canary Islands
2026 Sails: Jan 30, More...

MSC Cruises, MSC Musica

7 Night - Canary Islands and Madeira
Starting in Las Palmas de Gran Canaria (Canary Islands), Spain, Funchal (Madeira Islands), Portugal, Santa Cruz de Tenerife, Arrecife De Lanzarote (Canary Islands), Spain, Puerto Del Rosario / Fuerteventura, Spain, Santa Cruz de La Palma, Las Palmas de Gran Canaria (Canary Islands), Spain
2026 Sails: Jan 30, Feb 6, Feb 13, Feb 20, Feb 27, Mar 6, Mar 13, Mar 20, Mar 27, Apr 3, More...

MSC Cruises, MSC World Europa

7 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain
2026 Sails: Jan 30, Feb 6, Feb 13, Feb 20, Feb 27, Mar 6, Mar 13, Mar 20, Mar 27, Apr 3, Apr 10, More...

MSC Cruises, MSC Orchestra

7 Night - Mediterranean
Starting in Valencia, Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Livorno (Florence), Italy, Civitavecchia (Rome), Italy, Valencia, Spain
2026 Sails: Jan 31, Feb 7, Feb 14, Feb 21, Feb 28, Mar 7, Mar 14, Mar 21, Mar 28, Apr 4, Apr 11, More...

MSC Cruises, MSC Musica

7 Night - Canary Islands and Madeira
Starting in Santa Cruz de Tenerife, Arrecife De Lanzarote (Canary Islands), Spain, Puerto Del Rosario / Fuerteventura, Spain, Santa Cruz de La Palma, Las Palmas de Gran Canaria (Canary Islands), Spain, Funchal (Madeira Islands), Portugal, Santa Cruz de Tenerife
2026 Sails: Feb 1, Feb 8, Feb 15, Feb 22, Mar 1, Mar 8, Mar 15, Mar 22, Mar 29, Apr 5, More...

MSC Cruises, MSC Orchestra

7 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Livorno (Florence), Italy, Civitavecchia (Rome), Italy, Valencia, Spain, Barcelona, Spain
2026 Sails: Feb 1, Feb 8, Feb 15, Feb 22, Mar 1, Mar 8, Mar 15, Mar 22, Mar 29, Apr 5, Apr 12, More...

Viking Ocean, Viking Saturn

4 Night - Mediterranean Getaway
Starting in Barcelona, Sail the Mediterranean Sea, Valletta, Sail the Mediterranean Sea, Athens (Piraeus)
2026 Sails: Feb 1, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean from Barcelona
Starting in Barcelona, La Goulette, Palermo, Civitavecchia, Savona, Marseille, Barcelona
2026 Sails: Feb 2, Feb 9, Feb 16, Feb 23, Mar 2, Mar 9, More...

Celebrity Cruises, Celebrity Infinity

13 Night - Greece, Italy & Turkey Cruise
Starting in Barcelona, Spain, Sicily (Messina), Italy, Valletta, Malta, Heraklion (Iraklion), Crete, Rhodes, Greece, Ephesus (Kusadasi), Turkey, Thessaloniki, Greece, Nafplio, Greece, Athens (Piraeus), Greece
2026 Sails: Feb 3, More...

Viking Ocean, Viking Vesta

14 Night - Mediterranean Antiquities
Starting in Barcelona, Sete, Marseille, Villefranche-Sur-Mer, Florence / Pisa (Livorno), Rome (Civitavecchia), Naples, Sicily (Messina), Sail the Ionian Sea, Crete (Souda Bay), Ephesus (Kusadasi), Athens (Piraeus)
2026 Sails: Feb 3, More...

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