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Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Departing from
Spain
Cruise Specials

Viking Ocean, Viking Sea
Viking Sea10 Night - Icons of the Mediterranean
Starting in Barcelona (Tarragona), Marseille, Villefranche-Sur-Mer, Florence / Pisa (Livorno), Rome (Civitavecchia), Naples, Sicily (Messina), Sail the Ionian Sea, Crete (Heraklion), Athens (Piraeus)
2026 Sails: Sep 22, More...
Costa Cruise Lines, Costa Pacifica
Costa Pacifica7 Night - Western Mediterranean from Valencia
Starting in Valencia, Olbia (costa Smeralda), Civitavecchia (Rome), Savona, La Seyne (St Tropez), Palma De Mallorca, Valencia
2026 Sails: Sep 23, More...
Emerald Cruises, Emerald Radiance
Emerald Radiance10 Night - Madrid & Secrets of the Douro
Starting in Madrid, Madrid / Porto, Porto / Pinhao, Pinhao / Vega de Terron, Vega de Terron / Salamanca, Pocinho / Regua, Regua, Porto
2026 Sails: Sep 23, More...
Emerald Cruises, Emerald Radiance
Emerald Radiance13 Night - Madrid to Lisbon & Secrets of the Douro
Starting in Madrid, Madrid / Porto, Porto / Pinhao, Pinhao / Vega de Terron, Vega de Terron / Salamanca, Pocinho / Regua, Regua, Porto, Porto / Lisbon, Lisbon
2026 Sails: Sep 23, More...
PONANT, Le Champlain
Le Champlain8 Night - Southern France and the Italian Riviera by Sea - with Smithsonian Journeys
Starting in Barcelona, Sete, Marseille, Nice, Santa Margherita Ligure, Porto Venere, Livorno, Bonifacio, Corsica, Civitavecchia (Rome)
2026 Sails: Sep 23, More...
Scenic Luxury, Scenic Eclipse II
Scenic Eclipse II10 Night - Spain, French Riviera & the Balearic Islands : Tastes of Discovery Voyage with Chef Begona Rodrigo
Starting in Barcelona, Spain, Palamos, Spain, Sanary-sur-Mer, France, Cannes, France, Saint-Tropez, France, Marseille, France, Mahon, Spain, Palma De Mallorca, Spain, Ibiza, Spain, Valencia, Spain, Barcelona, Spain
2026 Sails: Sep 23, More...
Viking Ocean, Viking Sky
Viking Sky7 Night - Iconic Western Mediterranean
Starting in Barcelona, Sete, Marseille, Monte Carlo, Florence / Pisa (Livorno), Rome (Civitavecchia)
2026 Sails: Sep 23, More...
Norwegian Line Tours, Norwegian Dawn Tours
Norwegian Dawn Tours10 Night - Explore Barcelona Pre Cruisetour
Starting in At Hotel, Barcelona, Spain, Palma Majorca, Spain, Valencia, Spain, Motril, Spain, Gibraltar, Cadiz / Seville, Spain, Barcelona (Tarragona), Spain
2026 Sails: Sep 24, More...
Costa Cruise Lines, Costa Diadema
Costa Diadema3 Night - Southern Europe from Palma De Mallorca to Barcelona
Starting in Palma De Mallorca, Spain, Marseille, France, Savona, Italy, Barcelona, Spain
2026 Sails: Sep 25, More...
SeaDream Yacht Club, SeaDream II
SeaDream II7 Night - French Riviera Delight Cruise
Starting in Barcelona, Collioure, Sete, Saint-Cyr-sur-Mer, Sanary-sur-mer, St Tropez, Cannes, Nice
2026 Sails: Sep 26, More...

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Spain Cruise Departures