Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron : Vigo

Princess Cruises, Sun Princess

14 Night - Mediterranean with Greece, Italy & Turkey
Starting in Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, Santa Margherita, Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: Apr 25, More...

Princess Cruises, Sun Princess

7 Night - Western Mediterranean with Italy
Starting in Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, Santa Margherita, Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy
2026 Sails: Apr 25, More...

MSC Cruises, MSC Seaview

4 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Barcelona, Spain
2026 Sails: Apr 26, More...

Norwegian Cruise Line, Norwegian Dawn

7 Night - Europe - Western Mediterranean - Barcelona
Starting in Barcelona, Spain, Palma Majorca, Spain, Valencia, Spain, Motril, Spain, Gibraltar, Cadiz / Seville, Spain, Portimao, Portugal, Lisbon, Portugal
2026 Sails: Apr 26, May 10, May 24, Jun 7, Jun 21, Jul 5, Jul 19, Aug 2, Aug 16, Aug 30, Sep 13, Sep 27, Oct 11, More...

Norwegian Cruise Line, Norwegian Pearl

7 Night - Europe - Western Mediterranean - Barcelona
Starting in Barcelona, Spain, Valletta, Malta, Corfu, Greece, Dubrovnik, Croatia, Kotor, Montenegro, Split, Croatia, Venice (Ravenna), Italy
2026 Sails: Apr 26, More...

Norwegian Line Tours, Norwegian Viva Tours

12 Night - Explore Barcelona Pre Cruisetour
Starting in At Hotel, Barcelona, Spain, Nice / Monaco (Villefranche), France, Livorno / Florence / Pisa, Italy, Civitavecchia Rome, Italy, Amalfi Coast (Salerno), Italy, Messina, Italy, Corfu, Greece, Kotor, Montenegro, Split, Croatia, Venice (Ravenna), Italy
2026 Sails: Apr 26, Jun 21, More...

Windstar, Wind Surf

8 Night - Yachtsman's Harbors of the Rivieras
Starting in Barcelona, Palamos, Port Vendres, Sanary-sur-mer, Monte Carlo, Cannes, Portofino, Portoferraio, Rome
2026 Sails: Apr 26, More...

Windstar Tours, Wind Surf Tours

10 Night - Vatican & Italian Riviera Cruise Tour
Starting in Barcelona, Palamos, Port Vendres, Sanary-sur-mer, Monte Carlo, Cannes, Portofino, Portoferraio, Rome
2026 Sails: Apr 26, More...

MSC Cruises, MSC Fantasia

6 Night - Mediterranean
Starting in Barcelona, Spain, La Valletta, Malta, Corfu, Greece, Bari, Italy, Trieste (Venice), Italy
2026 Sails: Apr 27, More...

MSC Cruises, MSC Fantasia

11 Night - Mediterranean
Starting in Barcelona, Spain, La Valletta, Malta, Corfu, Greece, Bari, Italy, Trieste (Venice), Italy, Katakolon (Olympia), Greece, Piraeus (Athens), Greece, Izmir (Ephesus), Turkey, Istanbul, Turkey
2026 Sails: Apr 27, More...

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