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Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Departing from
Spain
Cruise Specials

Costa Cruise Lines, Costa Smeralda
Costa Smeralda7 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Cagliari, Palermo, Civitavecchia (Rome), Savona, Marseille, Barcelona
2026 Sails: Nov 2, More...
MSC Cruises, MSC Divina
MSC Divina14 Night - Msc Grand Voyages
Starting in Tarragona, Spain, Santa Cruz de Tenerife, Salvador, Brazil, Rio De Janeiro, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Nov 2, More...
MSC Cruises, MSC Opera
MSC Opera14 Night - Msc Grand Voyages
Starting in Barcelona, Spain, Tangier (Tetouan), Morocco, St Johns AG, Antigua, Philipsburg, St Maarten, Basseterre, St Kitts and Nevis, La Romana, Dominican Republic
2026 Sails: Nov 2, More...
Oceania Cruises, Oceania Insignia
Oceania Insignia7 Night - Iberian Explorer
Starting in Barcelona, Palma De Mallorca, Alicante, Cartagena ES, Malaga, Seville (Cadiz), Portimao, Lisbon
2026 Sails: Nov 2, More...
Oceania Cruises, Oceania Insignia
Oceania Insignia47 Night - Footsteps of Columbus
Starting in Barcelona, Palma De Mallorca, Alicante, Cartagena ES, Malaga, Seville (Cadiz), Portimao, Lisbon, Arrecife (Lanzarote), Las Palmas De Gran Canaria, Santa Cruz de La Palma, San Juan, Puerto Plata, Dominican Republic, Miami, Tortola, St Johns AG, Castries, Scarborough, Cruising the Amazon River, Santarem (Amazon River), Boca Da Valeria (Amazon River), Manaus (Amazon River), Parintins (Amazon River), Alter Do Chao (Amazon River), Cruising the Amazon River, Bridgetown, Roseau, Philipsburg, San Juan, Nassau, Miami
2026 Sails: Nov 2, More...
Oceania Insignia22 Night - Flamenco to Flamingos
Starting in Barcelona, Palma De Mallorca, Alicante, Cartagena ES, Malaga, Seville (Cadiz), Portimao, Lisbon, Arrecife (Lanzarote), Las Palmas De Gran Canaria, Santa Cruz de La Palma, San Juan, Puerto Plata, Dominican Republic, Miami
2026 Sails: Nov 2, More...
Royal Caribbean, Brilliance of the Seas
Brilliance of the Seas14 Night - Spain & Bermuda Transatlantic
Starting in Barcelona, Spain, Valencia, Spain, Cartagena ES, Malaga, Spain, Ponta Delgada, Azores, Royal Naval Dockyard, Bermuda, Fort Lauderdale, Florida
2026 Sails: Nov 2, More...
Sea Cloud, Sea Cloud Spirit
Sea Cloud Spirit11 Night - Imperial Cities and Volcanoes
Starting in Malaga, Cadiz, Tangier, Casablanca, Agadir, Arrecife / Lanzarote, Las Palmas / Gran Canaria
2026 Sails: Nov 2, More...
Costa Cruise Lines, Costa Diadema
Costa Diadema22 Night - Transatlantic from Barcelona to Itajai
Starting in Barcelona, Malaga, Cadiz, Lisbon, Las Palmas (Gran Canaria), Santa Cruz de Tenerife, Mindelo (Sao Vicente), Maceio, Salvador Bahia, Rio De Janeiro, Santos (Sao Paulo), Itajai
2026 Sails: Nov 3, More...
Costa Cruise Lines, Costa Diadema
Costa Diadema19 Night - Transatlantic from Barcelona
Starting in Barcelona, Malaga, Cadiz, Lisbon, Las Palmas (Gran Canaria), Santa Cruz de Tenerife, Mindelo (Sao Vicente), Maceio, Salvador Bahia, Rio De Janeiro
2026 Sails: Nov 3, More...

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Spain Cruise Departures