Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron : Vigo

Emerald Cruises, Emerald Sakara

10 Night - Islands of the Mediterranean : Spain to Malta
Starting in Barcelona, Spain, Mahon, Menorca, Spain, Bonifacio, France, Bonifacio, France / Porto Cervo, Italy, Porto Cervo, Italy, Cagliari, Italy, Trapani, Italy, Lipari, Italy, Giardini Naxos, Italy, Syracuse, Italy, Valletta, Malta
2026 Sails: Apr 25, More...

Explora Journeys, EXPLORA II

9 Night - A Journey of Golden Coastlines & Ancient Wonders
Starting in Barcelona, Monte Carlo, Portofino, Civitavecchia (Rome), Sorrento, Monemvasia, Milos, Piraeus (Athens)
2026 Sails: Apr 25, More...

Explora Journeys, EXPLORA II

16 Night - An Extended Journey of Colourful Cultures & Boundless Beauty
Starting in Barcelona, Monte Carlo, Portofino, Civitavecchia (Rome), Sorrento, Monemvasia, Milos, Piraeus (Athens), Patmos, Istanbul, Kusadasi, Mykonos, Piraeus (Athens)
2026 Sails: Apr 25, More...

Explora Journeys, EXPLORA II

4 Night - A Journey Through Riviera Elegance & Coastal Splendour
Starting in Barcelona, Monte Carlo, Portofino, Civitavecchia (Rome)
2026 Sails: Apr 25, More...

Explora Journeys, EXPLORA II

12 Night - A Journey of Discovery in Beguiling Nature & Colourful Idylls
Starting in Barcelona, Monte Carlo, Portofino, Civitavecchia (Rome), Sorrento, Monemvasia, Milos, Piraeus (Athens), Patmos, Istanbul
2026 Sails: Apr 25, More...

MSC Cruises, MSC Orchestra

7 Night - Mediterranean
Starting in Valencia, Spain, Livorno (Florence), Italy, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Tarragona, Spain, Valencia, Spain
2026 Sails: Apr 25, May 2, May 9, May 16, May 23, May 30, Jun 6, Jun 13, Jun 20, Jun 27, Jul 4, Jul 11, Jul 18, Jul 25, Aug 1, Aug 8, Aug 15, Aug 22, Aug 29, Sep 5, Sep 12, Sep 19, Sep 26, Oct 3, More...

MSC Cruises, MSC Orchestra

5 Night - Mediterranean
Starting in Valencia, Spain, Livorno (Florence), Italy, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Marseille (Provence), France
2026 Sails: Apr 25, More...

MSC Cruises, MSC Orchestra

4 Night - Mediterranean
Starting in Valencia, Spain, Livorno (Florence), Italy, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy
2026 Sails: Apr 25, More...

MSC Cruises, MSC Splendida

7 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Livorno (Florence), Italy, Cagliari (Sardinia), Italy, Palermo (Monreale), Italy, La Valletta, Malta, Barcelona, Spain
2026 Sails: Apr 25, May 10, May 17, May 24, May 31, Jun 7, Jun 14, Jun 21, Jun 28, Jul 5, Jul 12, Jul 19, Jul 26, Aug 2, Aug 9, Aug 16, Aug 23, Aug 30, Sep 6, Sep 13, Sep 20, Sep 27, Oct 4, Oct 11, More...

Princess Cruises, Sun Princess

21 Night - The Best of the Mediterranean
Starting in Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, Santa Margherita, Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece, Santorini, Greece, Montenegro, Corfu, Greece, Sicily (Messina), Italy, Barcelona, Spain
2026 Sails: Apr 25, More...

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