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Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron : Vigo

Departing from
Spain
Cruise Specials

Costa Cruise Lines, Costa Favolosa
Costa Favolosa11 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Savona, Marseille, Cartagena ES, Spain, Malaga, Gibraltar, Cadice, Lisbon, Barcelona
2026 Sails: Apr 22, More...
Costa Cruise Lines, Costa Pacifica
Costa Pacifica7 Night - Western Mediterranean from Valencia
Starting in Valencia, La Spezia, Civitavecchia, Savona, Marseille, Palma De Mallorca, Valencia
2026 Sails: Apr 22, More...
Holland America, Oosterdam
Oosterdam11 Night - Mediterranean Splendor : Amalfi Coast & Ancient Ruins
Starting in Barcelona, Spain, Villefranche-sur-Mer (Nice), France, Livorno (Florence / Pisa), Italy, Civitavecchia (Rome), Italy, Naples (Pompeii / Amalfi), Italy, Taormina, Italy, Souda (Chania), Greece, Rhodes, Greece, Kusadasi (Ephesus), Turkey, Piraeus (Athens), Greece
2026 Sails: Apr 22, More...
Windstar Tours, Wind Surf Tours
Wind Surf Tours12 Night - Yachtsman's Mediterranean Rivieras & Madrid Cruise Tour
Starting in Madrid, Spain, Barcelona, Palamos, Port Vendres, Sanary-sur-mer, Monte Carlo, Cannes, Portofino, Portoferraio, Rome
2026 Sails: Apr 22, More...
MSC Cruises, MSC Musica
MSC Musica7 Night - Mediterranean
Starting in Valencia, Spain, Ibiza (Balearic Islands), Spain, Cagliari (Sardinia), Italy, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Valencia, Spain
2026 Sails: Apr 23, Apr 30, May 7, May 14, May 21, May 28, Jun 4, Jun 11, Jun 18, Jun 25, Jul 2, Jul 16, Jul 23, Jul 30, Aug 13, Aug 20, Aug 27, Sep 3, More...
Norwegian Line Tours, Norwegian Pearl Tours
Norwegian Pearl Tours10 Night - Explore Barcelona Pre Cruisetour
Starting in At Hotel, Barcelona, Spain, Valletta, Malta, Corfu, Greece, Dubrovnik, Croatia, Kotor, Montenegro, Split, Croatia, Venice (Ravenna), Italy
2026 Sails: Apr 23, More...
MSC Cruises, MSC World Europa
MSC World Europa7 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy, Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain
2026 Sails: Apr 24, May 1, May 8, May 15, May 22, May 29, Jun 5, Jun 12, Jun 19, Jun 26, Jul 3, Jul 10, Jul 17, Jul 24, Jul 31, Aug 7, Aug 14, Aug 21, Aug 28, Sep 4, Sep 11, Sep 18, Sep 25, Oct 2, More...
Sea Cloud, Sea Cloud II
Sea Cloud II9 Night - The Most Beautiful Spring Moments
Starting in Palma De Mallorca, Mahon / Menorca, Alghero / Sardinia, Bonifacio / Corsica, Calvi / Corsica, Portoferraio / Elba, Livorno
2026 Sails: Apr 24, More...
Azamara Quest7 Night - France Intensive Cruise : Marseille, Cannes & Nice
Starting in Barcelona, Port Vendres, Sete, Provence (Marseille), St Tropez, Ajaccio, Corsica, Cannes, Nice
2026 Sails: Apr 25, More...
Celebrity Cruises, Celebrity Equinox
Celebrity Equinox10 Night - Greek Isles & Turkey
Starting in Barcelona, Spain, Valletta, Malta, Athens (Piraeus), Greece, Santorini, Greece, Ephesus (Kusadasi), Turkey, Mykonos, Greece, Olympia (Katakolon), Greece, Rome (Civitavecchia), Italy
2026 Sails: Apr 25, May 23, More...

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Spain Cruise Departures