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Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Departing from
Spain
Cruise Specials

Windstar, Wind Star
Wind Star10 Night - Treasures of Southern Spain & Morocco
Starting in Barcelona, Palma De Mallorca, Tarragona (Barcelona), Valencia, Cartagena ES, Malaga, Tangier, Lisbon
2026 Sails: Oct 31, More...
Windstar, Wind Star
Wind Star24 Night - Star Collector : Classic Crossing to Spain & More
Starting in Barcelona, Palma De Mallorca, Tarragona (Barcelona), Valencia, Cartagena ES, Malaga, Tangier, Lisbon, Bridgetown, Barbados
2026 Sails: Oct 31, More...
Explora Journeys, EXPLORA I
EXPLORA I24 Night - A Grand Journey of Vibrant Cultures, Mayan Marvels & Idyllic Beaches
Starting in Barcelona, Cadiz, Funchal (Madeira), St Johns AG, Antigua, Road Bay, San Juan, Miami, Merida (Progreso), Roatan Island, Belize City, Ocean Cay, Miami
2026 Sails: Nov 1, More...
EXPLORA I16 Night - A Grand Journey of Lively Culture & Stunning Beaches
Starting in Barcelona, Cadiz, Funchal (Madeira), St Johns AG, Antigua, Road Bay, San Juan, Miami
2026 Sails: Nov 1, More...
Explora Journeys, EXPLORA I
EXPLORA I11 Night - A Journey Across Atlantic Horizons to the Caribbean
Starting in Barcelona, Cadiz, Funchal (Madeira), St Johns AG, Antigua
2026 Sails: Nov 1, More...
MSC Cruises, MSC Sinfonia
MSC Sinfonia7 Night - Mediterranean
Starting in Tarragona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Livorno (Florence), Italy, Valencia, Spain, Palma De Mallorca (Balearic Islands), Spain, Barcelona, Spain
2026 Sails: Nov 1, More...
Norwegian Cruise Line, Norwegian Epic
Norwegian Epic14 Night - Repo - Transatlantic
Starting in Barcelona, Spain, Cadiz / Seville, Spain, Santa Cruz de Tenerife, St Thomas, Vi, Great Stirrup Cay, Bahamas, Orlando Beaches / Port Canaveral, Fl
2026 Sails: Nov 1, More...
PONANT, Le Laperouse
Le Laperouse10 Night - Volcanic Landscapes from Canary Islands to Cape Verde
Starting in Las Palmas de Gran Canaria, Canary Islands, Puerto del Rosario, Canary Islands, Arrecife de Lanzarote, Canary Islands, Santa Cruz de Tenerife, San Sebastian de la Gomera, Canary Islands, Mindelo, Praia, Dakar
2026 Sails: Nov 1, More...
SeaDream Yacht Club, SeaDream I
SeaDream I13 Night - Cruise from Malaga to St Maarten (Philipsburg)
Starting in Malaga, Funchal, Madeira, Philipsburg
2026 Sails: Nov 1, More...
Silversea, Silver Dawn
Silver Dawn7 Night - Barcelona to Civitavecchia
Starting in Barcelona, Palma De Mallorca, Cagliari (Sardinia), Tunis (La Goulette), Trapani, Sicily, Naples, Civitavecchia (Rome)
2026 Sails: Nov 1, More...

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Spain Cruise Departures