Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Cartagena ES : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Norwegian Cruise Line, Norwegian Viva

9 Night - Europe - Western Mediterranean - Barcelona
Starting in Barcelona, Spain, Nice / Monaco (Villefranche), France, Livorno / Florence / Pisa, Italy, Civitavecchia Rome, Italy, Amalfi Coast (Salerno), Italy, Messina, Italy, Corfu, Greece, Kotor, Montenegro, Split, Croatia, Venice (Ravenna), Italy
2026 Sails: Jun 24, Aug 19, More...

MSC Cruises, MSC Opera

10 Night - Mediterranean
Starting in Malaga (Granada), Spain, Cadiz (Seville), Spain, Lisbon (Cascais), Portugal, Alicante, Spain, Mahon, Menorca, Spain, Olbia, Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Malaga (Granada), Spain
2026 Sails: Jun 25, Sep 23, More...

Oceania Cruises, Oceania Allura

12 Night - Southern Europe Sojourn
Starting in Barcelona, Provence (Marseille), Monte Carlo, Ajaccio (Corsica), Rome (Civitavecchia), Amalfi / Positano, Taormina (Sicily), Katakolon, Kotor, Dubrovnik, Croatia, Pula / Rovinj, Trieste
2026 Sails: Jun 25, More...

Celebrity Cruises, Celebrity Xcel

7 Night - Italy & French Riviera
Starting in Barcelona, Spain, Nice (Villefranche), France, Portofino, Italy, Florence / Pisa (La Spezia), Italy, Rome (Civitavecchia), Italy, Naples, Italy, Barcelona, Spain
2026 Sails: Jun 27, Aug 22, Aug 29, More...

Princess Cruises, Sun Princess

14 Night - Mediterranean with Greece, Italy & Turkey
Starting in Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: Jun 27, Aug 29, 2027: Apr 11, More...

Princess Cruises, Sun Princess

7 Night - Western Mediterranean with Italy
Starting in Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy
2026 Sails: Jun 27, Aug 29, 2027: Apr 11, More...

Silversea, Silver Ray

8 Night - Barcelona to Monte Carlo
Starting in Barcelona, Palamos, Palma De Mallorca, Ibiza, Valencia, Cartagena ES, Spain, Saint Tropez, Monte Carlo
2026 Sails: Jun 27, More...

Royal Caribbean, Harmony of the Seas

7 Night - Western Mediterranean Cruise
Starting in Barcelona, Spain, Palma De Mallorca, Spain, Florence / Pisa (La Spezia), Italy, Rome (Civitavecchia), Italy, Naples, Italy, Barcelona, Spain
2026 Sails: Jun 28, Jul 5, Jul 12, Jul 19, More...

Virgin Voyages, Valiant Lady

6 Night - French Riviera, Italy, & Ibiza Overnight
Starting in Barcelona, Spain, Nice (Villafranche), France, Rome (Civitavecchia), Italy, Ajaccio, Corsica, France, Ibiza, Spain, Barcelona, Spain
2026 Sails: Jun 28, More...

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Ibiza
Starting in Ibiza, Valencia, Olbia, Civitavecchia (Rome), Savona, La Seyne (St Tropez), Palma De Mallorca
2026 Sails: Jun 30, More...

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