Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Costa Cruise Lines, Costa Diadema

3 Night - Southern Europe Roundtrip from Barcelona
Starting in Barcelona, Spain, Marseilles, France, Savona, Italy, Barcelona, Spain
2026 Sails: Oct 31, More...

MSC Cruises, MSC Grandiosa

14 Night - Msc Grand Voyages
Starting in Barcelona, Spain, Funchal (Madeira Islands), Portugal, San Juan, Puerto Rico, Miami, Florida, Port Canaveral (Orlando), Florida
2026 Sails: Oct 31, More...

MSC Cruises, MSC Grandiosa

13 Night - Msc Grand Voyages
Starting in Barcelona, Spain, Funchal (Madeira Islands), Portugal, San Juan, Puerto Rico, Miami, Florida
2026 Sails: Oct 31, More...

MSC Cruises, MSC Magnifica

5 Night - Mediterranean
Starting in Tarragona, Spain, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Tarragona, Spain
2026 Sails: Oct 31, More...

MSC Cruises, MSC Sinfonia

6 Night - Mediterranean
Starting in Valencia, Spain, Tarragona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Livorno (Florence), Italy, Valencia, Spain
2026 Sails: Oct 31, More...

MSC Cruises, MSC Sinfonia

2 Night - Mediterranean
Starting in Valencia, Spain, Tarragona, Spain, Marseille (Provence), France
2026 Sails: Oct 31, More...

MSC Cruises, MSC Sinfonia

8 Night - Mediterranean
Starting in Valencia, Spain, Tarragona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Livorno (Florence), Italy, Valencia, Spain, Palma De Mallorca (Balearic Islands), Spain, Barcelona, Spain
2026 Sails: Oct 31, More...

Oceania Cruises, Oceania Allura

7 Night - Luminous Mediterranean
Starting in Barcelona (Tarragona), Palamos, Sete, Provence (Marseille), Savona, Cinque Terre (La Spezia), Portoferraio (Elba), Rome (Civitavecchia)
2026 Sails: Oct 31, More...

Princess Cruises, Sun Princess

15 Night - Western Europe Passage
Starting in Barcelona, Spain, Malaga, Spain, Gibraltar, Seville (Cadiz), Spain, Santa Cruz de Tenerife, Fort Lauderdale, Florida
2026 Sails: Oct 31, More...

Royal Caribbean, Explorer of the Seas

13 Night - Spain, & Bermuda Transatlantic
Starting in Barcelona, Spain, Palma De Mallorca, Spain, Cartagena ES, Ponta Delgada, Azores, Royal Naval Dockyard, Bermuda, Orlando (Port Canaveral), Fl
2026 Sails: Oct 31, More...

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