Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron : Vigo

Star Clippers, Royal Clipper

7 Night - Malaga to Nice
Starting in Malaga, Spain, Valencia, Spain, Palma De Mallorca, Mallorca / Balearic Islands, Spain, Mahon / Menorca / Balearic Islands, Spain, Ajaccio / Corsica, France, Calvi / Corsica, France, Nice, France
2026 Sails: Apr 18, More...

Princess Tours, Sun Princess Tours

13 Night - Highlights of Spain - Tour 2A
Starting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, Santa Margherita, Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy
2026 Sails: Apr 19, More...

PONANT, Le Bougainville

8 Night - Atlantic Odyssey from the Canary Islands to the Iberian Peninsula
Starting in Las Palmas de Gran Canaria, Canary Islands, Arrecife de Lanzarote, Canary Islands, San Sebastian de la Gomera, Canary Islands, Santa Cruz de Tenerife, Funchal, Madeira, Tangier, Malaga
2026 Sails: Apr 20, More...

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Palma De Mallorca
Starting in Palma De Mallorca, Valencia, La Spezia, Civitavecchia, Savona, Marseille, Palma De Mallorca
2026 Sails: Apr 21, More...

MSC Cruises, MSC Fantasia

6 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Naples (Pompeii), Italy, Barcelona, Spain
2026 Sails: Apr 21, More...

Oceania Cruises, Oceania Marina

7 Night - Etruscan Waterways
Starting in Barcelona, Toulon, Portofino, Cinque Terre (La Spezia), Ajaccio (Corsica), Olbia / Porto Cervo (Sardinia), Naples / Pompeii, Rome (Civitavecchia)
2026 Sails: Apr 21, More...

Oceania Cruises, Oceania Nautica

10 Night - Charmed Rivieras
Starting in Barcelona, Palamos, Sete, Provence (Marseille), Toulon, Ajaccio (Corsica), Golfo Aranci, Portofino, Florence / Pisa / Tuscany (Livorno), Portoferraio (Elba), Rome (Civitavecchia)
2026 Sails: Apr 21, More...

Regent Seven Seas, Seven Seas Grandeur

14 Night - Journey to the Golden Horn
Starting in Barcelona, Cruising the Strait of Messina, Messina (Sicily), Cruising the Mediterranean Sea, Alexandria EG, Cruising the Mediterranean Sea, Heraklion (Crete), Santorini, Athens (Piraeus), Mykonos, Istanbul, Barcelona, Cruising the Strait of Messina, Messina (Sicily), Cruising the Mediterranean Sea, Alexandria EG, Cruising the Mediterranean Sea, Heraklion (Crete), Santorini, Athens (Piraeus), Mykonos, Istanbul
2026 Sails: Apr 21, More...

Sea Cloud, Sea Cloud II

4 Night - Western Mediterranean from Malaga to Palma De Mallorca
Starting in Malaga, Ibiza City / Ibiza, Palma De Mallorca
2026 Sails: Apr 21, More...

AmaWaterways Tours, AmaVida Tours

13 Night - Flavors of Portugal & Spain with Madrid Pre-Cruise
Starting in Madrid, Salamanca, Vega de Terron, Barca dAlva, Pinhao, Regua, Entre-os-Rios, Porto
2026 Sails: Apr 22, More...

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