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Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron : Vigo

Departing from
Spain
Cruise Specials

Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa2 Night - Europe from Barcelona to Savona
Starting in Barcelona, Marseille, Savona
2026 Sails: Apr 14, More...
Costa Cruise Lines, Costa Pacifica
Costa Pacifica7 Night - Western Mediterranean from Palma De Mallorca
Starting in Palma De Mallorca, Alicante, La Spezia, Civitavecchia, Savona, Marseille, Palma De Mallorca
2026 Sails: Apr 14, More...
Costa Cruise Lines, Costa Pacifica
Costa Pacifica7 Night - Western Mediterranean from Alicante
Starting in Alicante, La Spezia, Civitavecchia, Savona, Marseille, Palma De Mallorca, Valencia
2026 Sails: Apr 15, More...
Emerald Cruises, Emerald Sakara
Emerald Sakara20 Night - Discover the Yachting Treasures of the Mediterranean
Starting in Santa Cruz de Tenerife, Arrecife, Spain, Casablanca, Morocco, Cadiz, Spain, Malaga, Spain, Cartagena ES, Ibiza, Spain, Palma De Mallorca, Spain, Barcelona, Spain, Mahon, Menorca, Spain, Bonifacio, France, Bonifacio, France / Porto Cervo, Italy, Porto Cervo, Italy, Cagliari, Italy, Trapani, Italy, Lipari, Italy, Giardini Naxos, Italy, Syracuse, Italy, Valletta, Malta
2026 Sails: Apr 15, More...
Emerald Cruises, Emerald Sakara
Emerald Sakara10 Night - Canary Islands & Spanish Coast
Starting in Santa Cruz de Tenerife, Arrecife, Spain, Casablanca, Morocco, Cadiz, Spain, Malaga, Spain, Cartagena ES, Ibiza, Spain, Palma De Mallorca, Spain, Barcelona, Spain
2026 Sails: Apr 15, More...
Celebrity Cruises, Celebrity Equinox
Celebrity Equinox9 Night - Best of Spain & Portugal
Starting in Barcelona, Spain, Seville (Cadiz), Spain, Lisbon, Portugal, Porto (Leixoes), Portugal, Malaga, Spain, Palma De Mallorca, Spain, Barcelona, Spain
2026 Sails: Apr 16, More...
Costa Cruise Lines, Costa Fortuna
Costa Fortuna14 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Marseille, Savona, Civitavecchia, Messina, Izmir, Istanbul, Athens (Piraeus), La Goulette, Barcelona
2026 Sails: Apr 16, More...
MSC Cruises, MSC Preziosa
MSC Preziosa10 Night - MSC Grand Voyages
Starting in Vigo (Santiago De Compostela), Spain, Gijon, Spain, Southampton (London), United Kingdom, Le Havre (Paris), France, Zeebrugge (Bruges), Belgium, Copenhagen, Denmark, Oslo, Norway, Hamburg, Germany
2026 Sails: Apr 16, More...
PONANT, Le Champlain
Le Champlain10 Night - Volcanic Islands and Historic Cities of the North Atlantic
Starting in Las Palmas de Gran Canaria, Canary Islands, Santa Cruz de Tenerife, San Sebastian de la Gomera, Canary Islands, Santa Cruz de La Palma, Funchal, Madeira, Cadiz, Huelva, Lisbon
2026 Sails: Apr 16, More...
Royal Caribbean, Odyssey of the Seas
Odyssey of the Seas8 Night - Italy, France & Spain Cruise
Starting in Barcelona, Spain, Palma De Mallorca, Spain, Nice (Villefranche), France, Florence / Pisa (La Spezia), Italy, Sicily (Messina), Italy, Naples, Italy, Rome (Civitavecchia), Italy
2026 Sails: Apr 16, More...

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Spain Cruise Departures