Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Cartagena ES : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Princess Cruises, Sun Princess

14 Night - Mediterranean with Greece, Italy & Turkey
Starting in Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: Jun 6, More...

Princess Cruises, Sun Princess

7 Night - Western Mediterranean with Italy
Starting in Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy
2026 Sails: Jun 6, More...

Costa Cruise Lines, Costa Toscana

7 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Cagliari, Napoli, Civitavecchia (Rome), Genoa (Portofino), Marseille, Barcelona
2026 Sails: Jun 7, Jun 14, Jun 21, Jun 28, Jul 5, Jul 12, Jul 19, More...

Norwegian Cruise Line, Norwegian Dawn

7 Night - Europe - Western Mediterranean - Barcelona
Starting in Barcelona, Spain, Palma Majorca, Spain, Valencia, Spain, Motril, Spain, Gibraltar, Cadiz / Seville, Spain, Portimao, Portugal, Lisbon, Portugal
2026 Sails: Jun 7, More...

Virgin Voyages, Valiant Lady

7 Night - French Riviera, Italy & Ibiza Overnight
Starting in Barcelona, Spain, Toulon, France, Marina di Carrara, Italy, Ajaccio, Corsica, France, Ibiza, Spain, Barcelona, Spain
2026 Sails: Jun 7, More...

Costa Cruise Lines, Costa Smeralda

8 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Ibiza, Palermo, Civitavecchia (Rome), Savona, Marseille, Ibiza, Barcelona
2026 Sails: Jun 8, More...

MSC Cruises, MSC Opera

10 Night - Mediterranean
Starting in Alicante, Spain, Mahon, Menorca, Spain, Olbia, Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Malaga (Granada), Spain, Cadiz (Seville), Spain, Lisbon (Cascais), Portugal, Alicante, Spain
2026 Sails: Jun 9, More...

Silversea, Silver Ray

12 Night - Barcelona to Monte Carlo
Starting in Barcelona, Palma De Mallorca, Valencia, Tunis (La Goulette), Trapani, Sicily, Sorrento, Porto Santo Stefano, Livorno (Tuscany), Portofino, Toulon, Monte Carlo
2026 Sails: Jun 9, More...

Azamara Cruises, Azamara Onward

44 Night - Barcelona to Athens Grand Voyage
Starting in Barcelona, Palamos, Sete, Provence (Marseille), Sanary-sur-mer, Nice, Calvi, Monte Carlo, Portofino (Santa Margherita), Florence / Pisa (Livorno), Rome (Civitavecchia), Sorrento, Kotor, Dubrovnik, Croatia, Hvar, Koper, Venice (Fusina), Opatija, Zadar, Sibenik, Korcula, Dubrovnik, Croatia, Kotor, Corfu, Athens (Piraeus), Syros, Paros, Santorini, Agios Nikolaos, (Crete), Rhodes, Ephesus (Kusadasi), Patmos, Chios, Istanbul, Canakkale (Kepez), Thessaloniki, Volos, Mykonos, Nafplio, Athens (Piraeus)
2026 Sails: Jun 11, More...

Celebrity Cruises, Celebrity Equinox

9 Night - Spain, Portugal & Morocco
Starting in Barcelona, Spain, Seville (Cadiz), Spain, Lisbon, Portugal, Porto (Leixoes), Portugal, Tangier, Morocco, Barcelona, Spain
2026 Sails: Jun 11, More...

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