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Santo Domingo Cruise Departures

Cruises that depart from Caribbean: Dominican Republic: Santo Domingo

Cruises that visit Santo Domingo

Click on a cruise ship itinerary sailing from Santo Domingo (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Santo Domingo), please visit: Cruise Search or try our Virtual Cruise Advisor™.


Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa Cruises7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, Basseterre, Tortola (Road Harbour), Santo Domingo
2026 Sails: Jan 26, Feb 2, Feb 9, Feb 16, Feb 23, Mar 2, More...
Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa Cruises4 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre
2026 Sails: Jan 26, Feb 2, Mar 2, More...
Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa Cruises19 Night - Transatlantic from Santo Domingo
Starting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, St Lucia Castries, Bridgetown, Barbados, Santa Cruz de Tenerife, Tangier, Barcelona, Marseille, Savona
2026 Sails: Mar 9, More...
Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa Cruises18 Night - Transatlantic from Santo Domingo
Starting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, St Lucia Castries, Bridgetown, Barbados, Santa Cruz de Tenerife, Tangier, Barcelona, Marseille
2026 Sails: Mar 9, More...
Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa Cruises17 Night - Transatlantic from Santo Domingo
Starting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, St Lucia Castries, Bridgetown, Barbados, Santa Cruz de Tenerife, Tangier, Barcelona
2026 Sails: Mar 9, More...
Costa Cruise Lines, Costa Favolosa
Costa Favolosa Cruise Ship7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Pointe-a-Pitre, Fort-de-France, Basseterre, St Johns AG, Antigua, Tortola (Road Harbour), Santo Domingo
2026 Sails: Nov 30, More...
Costa Cruise Lines, Costa Favolosa
Costa Favolosa Cruise Ship7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Fort-de-France, Pointe-a-Pitre, Basseterre, St Johns AG, Antigua, Tortola (Road Harbour), Santo Domingo
2026 Sails: Dec 7, More...
Costa Cruise Lines, Costa Favolosa
Costa Favolosa Cruise Ship7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Fort-de-France, Pointe-a-Pitre, Basseterre, Tortola (Road Harbour), Catalina Island, Santo Domingo
2026 Sails: Dec 14, More...
Costa Cruise Lines, Costa Favolosa
Costa Favolosa Cruise Ship7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Fort-de-France, Pointe-a-Pitre, St Maarten (Philipsburg), Basseterre, Tortola (Road Harbour), Santo Domingo
2026 Sails: Dec 21, More...
Costa Cruise Lines, Costa Favolosa
Costa Favolosa Cruise Ship7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Fort-de-France, Pointe-a-Pitre, St Lucia Castries, Basseterre, St Maarten (Philipsburg), Santo Domingo
2026 Sails: Dec 28, More...

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Santo Domingo Cruise Departures