Santo Domingo Cruise Departures
Cruises that depart from Caribbean: Dominican Republic: Santo Domingo
Cruises that visit Santo Domingo
7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Dominican Republic, Guadeloupe (Antilles), Martinique (Antilles), St Kitts (Antilles), Antigua (Antilles), Road Harbour / Tortola, Santo Domingo, Dominican Republic
2026 Sails: Nov 30, More...7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Dominican Republic, Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), St Kitts (Antilles), Antigua (Antilles), Road Harbour / Tortola, Santo Domingo, Dominican Republic
2026 Sails: Dec 7, More...7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Dominican Republic, Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), St Kitts (Antilles), Antigua (Antilles), Road Harbour / Tortola, Santo Domingo, Dominican Republic
2026 Sails: Dec 14, More...7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Dominican Republic, Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), Philipsburg, St Kitts (Antilles), Road Harbour / Tortola, Santo Domingo, Dominican Republic
2026 Sails: Dec 21, More...7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Dominican Republic, Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), Castries, St Kitts (Antilles), Philipsburg, Santo Domingo, Dominican Republic
2026 Sails: Dec 28, More...7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Dominican Republic, Antigua (Antilles), Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), St Kitts (Antilles), Road Harbour / Tortola, Santo Domingo, Dominican Republic
2027 Sails: Jan 4, Feb 8, Feb 15, Feb 22, More...7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Dominican Republic, Philipsburg, Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), St Kitts (Antilles), Road Harbour / Tortola, Santo Domingo, Dominican Republic
2027 Sails: Jan 11, More...7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Dominican Republic, Antigua (Antilles), Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), St Kitts (Antilles), Philipsburg, Santo Domingo, Dominican Republic
2027 Sails: Jan 18, More...7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Dominican Republic, Roseau, Dominica, Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), St Kitts (Antilles), Road Harbour / Tortola, Santo Domingo, Dominican Republic
2027 Sails: Jan 25, More...7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Dominican Republic, Antigua (Antilles), Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), St Kitts (Antilles), Philipsburg, Santo Domingo, Dominican Republic
2027 Sails: Feb 1, More...
Cruises that depart from Caribbean: Dominican Republic: Santo Domingo
Cruises that visit Santo Domingo
Click on a cruise ship itinerary sailing from Santo Domingo (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Santo Domingo), please visit: Cruise Search or try our Virtual Cruise Advisor™.
7 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Dominican Republic, Guadeloupe (Antilles), Martinique (Antilles), St Kitts (Antilles), Antigua (Antilles), Road Harbour / Tortola, Santo Domingo, Dominican Republic
2026 Sails: Nov 30, More...
7 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Dominican Republic, Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), St Kitts (Antilles), Antigua (Antilles), Road Harbour / Tortola, Santo Domingo, Dominican Republic
2026 Sails: Dec 7, More...
7 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Dominican Republic, Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), St Kitts (Antilles), Antigua (Antilles), Road Harbour / Tortola, Santo Domingo, Dominican Republic
2026 Sails: Dec 14, More...
7 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Dominican Republic, Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), Philipsburg, St Kitts (Antilles), Road Harbour / Tortola, Santo Domingo, Dominican Republic
2026 Sails: Dec 21, More...
7 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Dominican Republic, Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), Castries, St Kitts (Antilles), Philipsburg, Santo Domingo, Dominican Republic
2026 Sails: Dec 28, More...
7 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Dominican Republic, Antigua (Antilles), Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), St Kitts (Antilles), Road Harbour / Tortola, Santo Domingo, Dominican Republic
2027 Sails: Jan 4, Feb 8, Feb 15, Feb 22, More...
7 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Dominican Republic, Philipsburg, Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), St Kitts (Antilles), Road Harbour / Tortola, Santo Domingo, Dominican Republic
2027 Sails: Jan 11, More...
7 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Dominican Republic, Antigua (Antilles), Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), St Kitts (Antilles), Philipsburg, Santo Domingo, Dominican Republic
2027 Sails: Jan 18, More...
7 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Dominican Republic, Roseau, Dominica, Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), St Kitts (Antilles), Road Harbour / Tortola, Santo Domingo, Dominican Republic
2027 Sails: Jan 25, More...
7 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Dominican Republic, Antigua (Antilles), Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), St Kitts (Antilles), Philipsburg, Santo Domingo, Dominican Republic
2027 Sails: Feb 1, More...
