Santo Domingo Cruise Departures
Cruises that depart from Caribbean: Dominican Republic: Santo Domingo
Cruises that visit Santo Domingo
18 Night - Transatlantic from Santo Domingo
Starting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, Castries, St Lucia, Bridgetown, Barbados, Santa Cruz de Tenerife, Tangier, Barcelona, Marseille
2026 Sails: Mar 9, More...17 Night - Transatlantic from Santo Domingo
Starting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, Castries, St Lucia, Bridgetown, Barbados, Santa Cruz de Tenerife, Tangier, Barcelona
2026 Sails: Mar 9, More...
7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Dominican Republic, Guadeloupe (Antilles), Martinique (Antilles), St Kitts (Antilles), Antigua (Antilles), Tortola, British Virgin Islands, Santo Domingo, Dominican Republic
2026 Sails: Nov 30, More...7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Dominican Republic, Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), St Kitts (Antilles), Antigua (Antilles), Tortola, British Virgin Islands, Santo Domingo, Dominican Republic
2026 Sails: Dec 7, More...7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Dominican Republic, Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), St Kitts (Antilles), Tortola, British Virgin Islands, Catalina Island, Dominican Republic, Santo Domingo, Dominican Republic
2026 Sails: Dec 14, More...7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Dominican Republic, Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), St Maarten (Antilles), St Kitts (Antilles), Tortola, British Virgin Islands, Santo Domingo, Dominican Republic
2026 Sails: Dec 21, More...7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Dominican Republic, Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), St Lucia (Antilles), St Kitts (Antilles), St Maarten (Antilles), Santo Domingo, Dominican Republic
2026 Sails: Dec 28, More...7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Dominican Republic, Antigua (Antilles), Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), St Kitts (Antilles), Tortola, British Virgin Islands, Santo Domingo, Dominican Republic
2027 Sails: Jan 4, Feb 8, Feb 15, Feb 22, More...7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Dominican Republic, St Maarten (Antilles), Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), St Kitts (Antilles), Tortola, British Virgin Islands, Santo Domingo, Dominican Republic
2027 Sails: Jan 11, More...7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Dominican Republic, Antigua (Antilles), Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), St Kitts (Antilles), St Maarten (Antilles), Santo Domingo, Dominican Republic
2027 Sails: Jan 18, More...
Cruises that depart from Caribbean: Dominican Republic: Santo Domingo
Cruises that visit Santo Domingo
Click on a cruise ship itinerary sailing from Santo Domingo (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Santo Domingo), please visit: Cruise Search or try our Virtual Cruise Advisor™.
18 Night - Transatlantic from Santo DomingoStarting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, Castries, St Lucia, Bridgetown, Barbados, Santa Cruz de Tenerife, Tangier, Barcelona, Marseille
2026 Sails: Mar 9, More...
17 Night - Transatlantic from Santo DomingoStarting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, Castries, St Lucia, Bridgetown, Barbados, Santa Cruz de Tenerife, Tangier, Barcelona
2026 Sails: Mar 9, More...
7 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Dominican Republic, Guadeloupe (Antilles), Martinique (Antilles), St Kitts (Antilles), Antigua (Antilles), Tortola, British Virgin Islands, Santo Domingo, Dominican Republic
2026 Sails: Nov 30, More...
7 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Dominican Republic, Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), St Kitts (Antilles), Antigua (Antilles), Tortola, British Virgin Islands, Santo Domingo, Dominican Republic
2026 Sails: Dec 7, More...
7 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Dominican Republic, Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), St Kitts (Antilles), Tortola, British Virgin Islands, Catalina Island, Dominican Republic, Santo Domingo, Dominican Republic
2026 Sails: Dec 14, More...
7 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Dominican Republic, Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), St Maarten (Antilles), St Kitts (Antilles), Tortola, British Virgin Islands, Santo Domingo, Dominican Republic
2026 Sails: Dec 21, More...
7 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Dominican Republic, Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), St Lucia (Antilles), St Kitts (Antilles), St Maarten (Antilles), Santo Domingo, Dominican Republic
2026 Sails: Dec 28, More...
7 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Dominican Republic, Antigua (Antilles), Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), St Kitts (Antilles), Tortola, British Virgin Islands, Santo Domingo, Dominican Republic
2027 Sails: Jan 4, Feb 8, Feb 15, Feb 22, More...
7 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Dominican Republic, St Maarten (Antilles), Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), St Kitts (Antilles), Tortola, British Virgin Islands, Santo Domingo, Dominican Republic
2027 Sails: Jan 11, More...
7 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Dominican Republic, Antigua (Antilles), Martinique (Antilles), Martinique Bay, Guadeloupe (Antilles), St Kitts (Antilles), St Maarten (Antilles), Santo Domingo, Dominican Republic
2027 Sails: Jan 18, More...
