Santo Domingo Cruise Departures
Cruises that depart from Caribbean: Dominican Republic: Santo Domingo
Cruises that visit Santo Domingo
4 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre
2026 Sails: Jan 12, More...7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, Basseterre, Tortola (Road Harbour), Santo Domingo
2026 Sails: Jan 12, More...7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, Basseterre, St Maarten (Philipsburg), Santo Domingo
2026 Sails: Jan 19, More...7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, Basseterre, Tortola (Road Harbour), Santo Domingo
2026 Sails: Jan 26, Feb 2, Feb 9, Feb 16, Feb 23, Mar 2, More...4 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre
2026 Sails: Jan 26, Feb 2, Mar 2, More...19 Night - Transatlantic from Santo Domingo
Starting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, St Lucia Castries, Bridgetown, Barbados, Santa Cruz de Tenerife, Tangier, Barcelona, Marseille, Savona
2026 Sails: Mar 9, More...18 Night - Transatlantic from Santo Domingo
Starting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, St Lucia Castries, Bridgetown, Barbados, Santa Cruz de Tenerife, Tangier, Barcelona, Marseille
2026 Sails: Mar 9, More...17 Night - Transatlantic from Santo Domingo
Starting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, St Lucia Castries, Bridgetown, Barbados, Santa Cruz de Tenerife, Tangier, Barcelona
2026 Sails: Mar 9, More...
7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Dominican Republic, Guadeloupe (Antilles), Martinique (Antilles), St Kitts (Antilles), Antigua (Antilles), Tortola, British Virgin Islands, Santo Domingo, Dominican Republic
2026 Sails: Nov 30, More...7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Dominican Republic, Martinique (Antilles), Guadeloupe (Antilles), St Kitts (Antilles), Antigua (Antilles), Tortola, British Virgin Islands, Santo Domingo, Dominican Republic
2026 Sails: Dec 7, More...
Cruises that depart from Caribbean: Dominican Republic: Santo Domingo
Cruises that visit Santo Domingo
Click on a cruise ship itinerary sailing from Santo Domingo (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Santo Domingo), please visit: Cruise Search or try our Virtual Cruise Advisor™.
4 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre
2026 Sails: Jan 12, More...
7 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, Basseterre, Tortola (Road Harbour), Santo Domingo
2026 Sails: Jan 12, More...
7 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, Basseterre, St Maarten (Philipsburg), Santo Domingo
2026 Sails: Jan 19, More...
7 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, Basseterre, Tortola (Road Harbour), Santo Domingo
2026 Sails: Jan 26, Feb 2, Feb 9, Feb 16, Feb 23, Mar 2, More...
4 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre
2026 Sails: Jan 26, Feb 2, Mar 2, More...
19 Night - Transatlantic from Santo DomingoStarting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, St Lucia Castries, Bridgetown, Barbados, Santa Cruz de Tenerife, Tangier, Barcelona, Marseille, Savona
2026 Sails: Mar 9, More...
18 Night - Transatlantic from Santo DomingoStarting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, St Lucia Castries, Bridgetown, Barbados, Santa Cruz de Tenerife, Tangier, Barcelona, Marseille
2026 Sails: Mar 9, More...
17 Night - Transatlantic from Santo DomingoStarting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, St Lucia Castries, Bridgetown, Barbados, Santa Cruz de Tenerife, Tangier, Barcelona
2026 Sails: Mar 9, More...
7 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Dominican Republic, Guadeloupe (Antilles), Martinique (Antilles), St Kitts (Antilles), Antigua (Antilles), Tortola, British Virgin Islands, Santo Domingo, Dominican Republic
2026 Sails: Nov 30, More...
7 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Dominican Republic, Martinique (Antilles), Guadeloupe (Antilles), St Kitts (Antilles), Antigua (Antilles), Tortola, British Virgin Islands, Santo Domingo, Dominican Republic
2026 Sails: Dec 7, More...
