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Santo Domingo Cruise Departures

Cruises that depart from Caribbean: Dominican Republic: Santo Domingo

Cruises that visit Santo Domingo

Click on a cruise ship itinerary sailing from Santo Domingo (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Santo Domingo), please visit: Cruise Search or try our Virtual Cruise Advisor™.


Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa Cruises7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, Basseterre, Tortola (Road Harbour), Santo Domingo
2025 Sails: Dec 8, More...
Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa Cruises4 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre
2025 Sails: Dec 8, More...
Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa Cruises7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, St Maarten (Philipsburg), Basseterre, Santo Domingo
2025 Sails: Dec 15, More...
Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa Cruises7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Fort-de-France, St Lucia Castries, Pointe-a-Pitre, Basseterre, Tortola (Road Harbour), Santo Domingo
2025 Sails: Dec 22, More...
Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa Cruises7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Fort-de-France, St Johns AG, Antigua, Pointe-a-Pitre, Basseterre, Tortola (Road Harbour), Santo Domingo
2025 Sails: Dec 29, More...
Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa Cruises4 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre
2026 Sails: Jan 5, Jan 12, More...
Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa Cruises3 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Catalina Island, Fort-de-France
2026 Sails: Jan 5, More...
Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa Cruises7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, Basseterre, Tortola (Road Harbour), Santo Domingo
2026 Sails: Jan 5, Jan 12, More...
Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa Cruises7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, Basseterre, St Maarten (Philipsburg), Santo Domingo
2026 Sails: Jan 19, More...
PONANT, Le Bellot
Le Bellot Cruises10 Night - The Essentials of the Caribbean
Starting in Santo Domingo, Jost Van Dyke, Les Saintes, Portsmouth UK, Pigeon Island Beach, Soufriere, Tobago Cays, Mayreau Island, Port Elizabeth VC, Bequia Island, Union Island, Fort-de-France
2026 Sails: Jan 19, More...

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Santo Domingo Cruise Departures