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Santo Domingo Cruise Departures

Cruises that depart from Caribbean: Dominican Republic: Santo Domingo

Cruises that visit Santo Domingo

Click on a cruise ship itinerary sailing from Santo Domingo (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Santo Domingo), please visit: Cruise Search or try our Virtual Cruise Advisor™.


Costa Cruise Lines, Costa Serena
Costa Serena17 Night - Cruise from Santo Domingo to Marseille
Starting in Santo Domingo, St Johns AG, Antigua, Fort-de-France, Pointe-a-Pitre, Philipsburg, Santa Cruz de Tenerife, Tangier, Barcelona, Marseille
2028 Sails: Mar 6, More...
Costa Cruise Lines, Costa Serena
Costa Serena16 Night - Cruise from Santo Domingo to Barcelona
Starting in Santo Domingo, St Johns AG, Antigua, Fort-de-France, Pointe-a-Pitre, Philipsburg, Santa Cruz de Tenerife, Tangier, Barcelona
2028 Sails: Mar 6, More...

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Santo Domingo Cruise Departures