Santo Domingo Cruise Departures
Cruises that depart from Caribbean: Dominican Republic: Santo Domingo
Cruises that visit Santo Domingo
7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, Basseterre, St Maarten (Philipsburg), Santo Domingo
2026 Sails: Jan 19, More...7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, Basseterre, Tortola (Road Harbour), Santo Domingo
2026 Sails: Jan 26, Feb 2, Feb 9, Feb 16, Feb 23, Mar 2, More...4 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre
2026 Sails: Jan 26, Feb 2, Mar 2, More...19 Night - Transatlantic from Santo Domingo
Starting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, St Lucia Castries, Bridgetown, Barbados, Santa Cruz de Tenerife, Tangier, Barcelona, Marseille, Savona
2026 Sails: Mar 9, More...18 Night - Transatlantic from Santo Domingo
Starting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, St Lucia Castries, Bridgetown, Barbados, Santa Cruz de Tenerife, Tangier, Barcelona, Marseille
2026 Sails: Mar 9, More...17 Night - Transatlantic from Santo Domingo
Starting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, St Lucia Castries, Bridgetown, Barbados, Santa Cruz de Tenerife, Tangier, Barcelona
2026 Sails: Mar 9, More...
7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Dominican Republic, Guadeloupe (Antilles), Martinique (Antilles), St Kitts (Antilles), Antigua (Antilles), Tortola, British Virgin Islands, Santo Domingo, Dominican Republic
2026 Sails: Nov 30, More...7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Dominican Republic, Martinique (Antilles), Guadeloupe (Antilles), St Kitts (Antilles), Antigua (Antilles), Tortola, British Virgin Islands, Santo Domingo, Dominican Republic
2026 Sails: Dec 7, More...7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Dominican Republic, Martinique (Antilles), Guadeloupe (Antilles), St Kitts (Antilles), Tortola, British Virgin Islands, Catalina Island, Dominican Republic, Santo Domingo, Dominican Republic
2026 Sails: Dec 14, More...7 Night - Western Caribbean from Santo Domingo
Starting in Santo Domingo, Dominican Republic, Martinique (Antilles), Guadeloupe (Antilles), St Maarten (Antilles), St Kitts (Antilles), Tortola, British Virgin Islands, Santo Domingo, Dominican Republic
2026 Sails: Dec 21, More...
Cruises that depart from Caribbean: Dominican Republic: Santo Domingo
Cruises that visit Santo Domingo
Click on a cruise ship itinerary sailing from Santo Domingo (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Santo Domingo), please visit: Cruise Search or try our Virtual Cruise Advisor™.
7 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, Basseterre, St Maarten (Philipsburg), Santo Domingo
2026 Sails: Jan 19, More...
7 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, Basseterre, Tortola (Road Harbour), Santo Domingo
2026 Sails: Jan 26, Feb 2, Feb 9, Feb 16, Feb 23, Mar 2, More...
4 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre
2026 Sails: Jan 26, Feb 2, Mar 2, More...
19 Night - Transatlantic from Santo DomingoStarting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, St Lucia Castries, Bridgetown, Barbados, Santa Cruz de Tenerife, Tangier, Barcelona, Marseille, Savona
2026 Sails: Mar 9, More...
18 Night - Transatlantic from Santo DomingoStarting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, St Lucia Castries, Bridgetown, Barbados, Santa Cruz de Tenerife, Tangier, Barcelona, Marseille
2026 Sails: Mar 9, More...
17 Night - Transatlantic from Santo DomingoStarting in Santo Domingo, Catalina Island, Fort-de-France, Pointe-a-Pitre, St Lucia Castries, Bridgetown, Barbados, Santa Cruz de Tenerife, Tangier, Barcelona
2026 Sails: Mar 9, More...
7 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Dominican Republic, Guadeloupe (Antilles), Martinique (Antilles), St Kitts (Antilles), Antigua (Antilles), Tortola, British Virgin Islands, Santo Domingo, Dominican Republic
2026 Sails: Nov 30, More...
7 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Dominican Republic, Martinique (Antilles), Guadeloupe (Antilles), St Kitts (Antilles), Antigua (Antilles), Tortola, British Virgin Islands, Santo Domingo, Dominican Republic
2026 Sails: Dec 7, More...
7 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Dominican Republic, Martinique (Antilles), Guadeloupe (Antilles), St Kitts (Antilles), Tortola, British Virgin Islands, Catalina Island, Dominican Republic, Santo Domingo, Dominican Republic
2026 Sails: Dec 14, More...
7 Night - Western Caribbean from Santo DomingoStarting in Santo Domingo, Dominican Republic, Martinique (Antilles), Guadeloupe (Antilles), St Maarten (Antilles), St Kitts (Antilles), Tortola, British Virgin Islands, Santo Domingo, Dominican Republic
2026 Sails: Dec 21, More...
