Rome Cruise Departures

Cruises that depart from Mediterranean: Italy: Rome

Cruises that visit Rome

Click on a cruise ship itinerary sailing from Rome (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Rome), please visit: Cruise Search or try our Virtual Cruise Advisor™.

10 Night - Italy, Greece & Croatia Cruise
Starting in Rome (Civitavecchia), Italy, Sicily (Messina), Italy, Olympia (Katakolon), Greece, Corfu, Greece, Dubrovnik, Croatia, Split, Croatia, Montenegro, Naples, Italy, Rome (Civitavecchia), Italy
2026 Sails: May 15, Aug 7, Sep 18, More...

Celebrity Cruises, Celebrity Constellation

11 Night - Best of Italy & Croatia Cruise
Starting in Rome (Civitavecchia), Italy, Florence / Pisa (La Spezia), Italy, Amalfi Coast (Salerno), Italy, Sicily (Messina), Italy, Kotor, Montenegro, Dubrovnik, Croatia, Split, Croatia, Zadar, Croatia, Ravenna, Italy
2026 Sails: May 18, More...

Viking Ocean, Viking Vesta

7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Villefranche-Sur-Mer, Marseille, Sete, Barcelona
2026 Sails: May 19, More...

Ritz-Carlton, Evrima

7 Night - Rome (Civitavecchia) / Nice
Starting in Rome (Civitavecchia), Portoferraio, Elba, Livorno, Monte Carlo, Ajaccio, Corsica, Calvi, Corsica, Nice
2026 Sails: May 20, More...

Windstar, Wind Surf

10 Night - Sicilian Splendors
Starting in Rome, Syracuse, Italy, Valletta, Gozo, Porto Empedocle, Trapani, Lipari, Sorrento, Amalfi, Rome
2026 Sails: May 21, More...

Windstar, Wind Surf

13 Night - Historic Harbors of Italy & Beyond
Starting in Rome, Syracuse, Italy, Valletta, Gozo, Porto Empedocle, Trapani, Lipari, Sorrento, Amalfi, Rome, Porto Venere, Bonifacio, France, Rome
2026 Sails: May 21, More...

Oceania Cruises, Oceania Nautica

10 Night - Italy & France Spotlight
Starting in Rome (Civitavecchia), Amalfi / Positano, Palermo (Sicily), Olbia / Porto Cervo (Sardinia), Bastia (Corsica), Piombino (Tuscany), Florence / Pisa / Tuscany (Livorno), Villefranche, Saint-Tropez, Toulon, Barcelona
2026 Sails: May 22, More...

Regent Seven Seas, Seven Seas Grandeur

13 Night - Spotlight On Faberge
Starting in Rome (Civitavecchia), Tuscany (Livorno), Monte Carlo, Barcelona, Cruising the Mediterranean Sea, Cruising the Atlantic Ocean, La Coruna, Cruising the English Channel, Paris (Honfleur), London (Southampton)
2026 Sails: May 24, More...

Celebrity Cruises, Celebrity Ascent

11 Night - Greece, Turkey & Italy Cruise
Starting in Rome (Civitavecchia), Italy, Chania (Souda), Crete, Greece, Istanbul, Turkey, Ephesus (Kusadasi), Turkey, Santorini, Greece, Mykonos, Greece, Naples, Italy, Rome (Civitavecchia), Italy
2026 Sails: May 25, More...

Royal Caribbean, Brilliance of the Seas

7 Night - Greek Isles & Italy Cruise
Starting in Rome (Civitavecchia), Italy, Naples, Italy, Sicily (Messina), Italy, Santorini, Greece, Ephesus (Kusadasi), Turkey, Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: May 25, Jul 6, Sep 28, More...

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