Rome Cruise Departures
Cruises that depart from Mediterranean: Italy: Rome
Cruises that visit Rome
12 Night - Enchanting Meteora, Greece, and Amalfi Coast Cruise Tour
Starting in Rome, Ponza, Sorrento, Amalfi, Messina (Taormina), Gythion, Monemvasia, Athens, Greece, Delphi, Athens, Greece
2026 Sails: Apr 24, More...8 Night - Enchanting Greece & the Amalfi Coast
Starting in Rome, Ponza, Sorrento, Amalfi, Messina (Taormina), Gythion, Monemvasia, Athens, Greece
2026 Sails: Apr 24, More...
11 Night - Best of Italy & Croatia Cruise
Starting in Rome (Civitavecchia), Italy, Florence / Pisa (La Spezia), Italy, Amalfi Coast (Salerno), Italy, Sicily (Messina), Italy, Kotor, Montenegro, Brindisi, Italy, Dubrovnik, Croatia, Split, Croatia, Trieste, Italy
2026 Sails: Apr 27, More...
7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Monte Carlo, Marseille, Sete, Barcelona
2026 Sails: Apr 27, More...
14 Night - Rivieras, Minarets & More
Starting in Rome (Civitavecchia), Cinque Terre (La Spezia), Saint-Tropez, Barcelona, Malaga, Seville (Cadiz), Casablanca, Agadir, Arrecife (Lanzarote), Santa Cruz de Tenerife, Santa Cruz de La Palma, Funchal (Madeira), Lisbon
2026 Sails: Apr 28, More...45 Night - Classic Europe Connoisseur
Starting in Rome (Civitavecchia), Cinque Terre (La Spezia), Saint-Tropez, Barcelona, Malaga, Seville (Cadiz), Casablanca, Agadir, Arrecife (Lanzarote), Santa Cruz de Tenerife, Santa Cruz de La Palma, Funchal (Madeira), Lisbon, Oporto, La Coruna, Gijon, Spain, Bilbao, Biarritz (Saint-Jean-De-Luz), Bordeaux, Saint-malo, St Peter Port, Guernsey, Paris (Le Havre), Cherbourg, Dunkirk, Bruges (Zeebrugge), Ijmuiden, London (Dover UK), Torbay, London (Southampton), Edinburgh (South Queensferry), Scrabster, Ullapool, Greencastle, Dublin (Dun Laoghaire), Holyhead, Fishguard, Waterford, Cork (Ringaskiddy), Portland UK, London (Southampton)
2026 Sails: Apr 28, More...
7 Night - Italian & Aegean Sampler
Starting in Rome (Civitavecchia), Amalfi / Positano, Catania (Sicily), Katakolon, Santorini, Milos, Mykonos, Athens (Piraeus)
2026 Sails: Apr 30, More...
11 Night - Enchanting Meteora, Greece, and Amalfi Coast Cruise Tour
Starting in Rome, Sorrento, Messina (Taormina), Gythion, Monemvasia, Athens, Greece, Delphi, Athens, Greece
2026 Sails: Apr 30, More...7 Night - Enchanting Greece & the Amalfi Coast
Starting in Rome, Sorrento, Messina (Taormina), Gythion, Monemvasia, Athens, Greece
2026 Sails: Apr 30, More...
10 Night - Italian & Aegean Idyll
Starting in Rome (Civitavecchia), Salerno, Trapani (Sicily), Tunis (La Goulette), Catania (Sicily), Katakolon, Monemvasia, Santorini, Ephesus (Kusadasi), Athens (Piraeus)
2026 Sails: May 1, More...
Cruises that depart from Mediterranean: Italy: Rome
Cruises that visit Rome
Click on a cruise ship itinerary sailing from Rome (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Rome), please visit: Cruise Search or try our Virtual Cruise Advisor™.
12 Night - Enchanting Meteora, Greece, and Amalfi Coast Cruise TourStarting in Rome, Ponza, Sorrento, Amalfi, Messina (Taormina), Gythion, Monemvasia, Athens, Greece, Delphi, Athens, Greece
2026 Sails: Apr 24, More...
8 Night - Enchanting Greece & the Amalfi CoastStarting in Rome, Ponza, Sorrento, Amalfi, Messina (Taormina), Gythion, Monemvasia, Athens, Greece
2026 Sails: Apr 24, More...
11 Night - Best of Italy & Croatia CruiseStarting in Rome (Civitavecchia), Italy, Florence / Pisa (La Spezia), Italy, Amalfi Coast (Salerno), Italy, Sicily (Messina), Italy, Kotor, Montenegro, Brindisi, Italy, Dubrovnik, Croatia, Split, Croatia, Trieste, Italy
2026 Sails: Apr 27, More...
7 Night - Iconic Western MediterraneanStarting in Rome (Civitavecchia), Florence / Pisa (Livorno), Monte Carlo, Marseille, Sete, Barcelona
2026 Sails: Apr 27, More...
14 Night - Rivieras, Minarets & MoreStarting in Rome (Civitavecchia), Cinque Terre (La Spezia), Saint-Tropez, Barcelona, Malaga, Seville (Cadiz), Casablanca, Agadir, Arrecife (Lanzarote), Santa Cruz de Tenerife, Santa Cruz de La Palma, Funchal (Madeira), Lisbon
2026 Sails: Apr 28, More...
45 Night - Classic Europe ConnoisseurStarting in Rome (Civitavecchia), Cinque Terre (La Spezia), Saint-Tropez, Barcelona, Malaga, Seville (Cadiz), Casablanca, Agadir, Arrecife (Lanzarote), Santa Cruz de Tenerife, Santa Cruz de La Palma, Funchal (Madeira), Lisbon, Oporto, La Coruna, Gijon, Spain, Bilbao, Biarritz (Saint-Jean-De-Luz), Bordeaux, Saint-malo, St Peter Port, Guernsey, Paris (Le Havre), Cherbourg, Dunkirk, Bruges (Zeebrugge), Ijmuiden, London (Dover UK), Torbay, London (Southampton), Edinburgh (South Queensferry), Scrabster, Ullapool, Greencastle, Dublin (Dun Laoghaire), Holyhead, Fishguard, Waterford, Cork (Ringaskiddy), Portland UK, London (Southampton)
2026 Sails: Apr 28, More...
7 Night - Italian & Aegean SamplerStarting in Rome (Civitavecchia), Amalfi / Positano, Catania (Sicily), Katakolon, Santorini, Milos, Mykonos, Athens (Piraeus)
2026 Sails: Apr 30, More...
11 Night - Enchanting Meteora, Greece, and Amalfi Coast Cruise TourStarting in Rome, Sorrento, Messina (Taormina), Gythion, Monemvasia, Athens, Greece, Delphi, Athens, Greece
2026 Sails: Apr 30, More...
7 Night - Enchanting Greece & the Amalfi CoastStarting in Rome, Sorrento, Messina (Taormina), Gythion, Monemvasia, Athens, Greece
2026 Sails: Apr 30, More...
Deal link -> Special
10 Night - Italian & Aegean IdyllStarting in Rome (Civitavecchia), Salerno, Trapani (Sicily), Tunis (La Goulette), Catania (Sicily), Katakolon, Monemvasia, Santorini, Ephesus (Kusadasi), Athens (Piraeus)
2026 Sails: May 1, More...
