Panama City Cruise Departures
Cruises that depart from Central America: Panama: Panama City
Cruises that visit Panama City
10 Night - Classic Panama Canal Passage
Starting in Panama City (Fuerte Amador), Scenic Sailing Panama Canal, Colon, Puerto Limon, Sail the Caribbean Sea, Roatan, Belize City, Cozumel, Mexico, Sail the Caribbean Sea, West Palm Beach, Florida
2026 Sails: Dec 17, More...
10 Night - Panama to Caribbean Joy
Starting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Santa Marta, Oranjestad, Willemstad AN, Ocho Rios, Jamaica, George Town, Miami
2027 Sails: Jan 15, More...
28 Night - Canal to Coral Reefs
Starting in Panama City, Cruising the Pacific Ocean, Puntarenas, Cruising the Pacific Ocean, Acajutla, Puerto Quetzal, Cruising the Pacific Ocean, Puerto Vallarta, Cabo San Lucas, Cruising the Pacific Ocean, Los Angeles, Cruising the Pacific Ocean, Honolulu, Kahului, Hilo, Cruising the Pacific Ocean, Bora Bora, Moorea, Papeete (Tahiti)
2027 Sails: Jan 26, More...
11 Night - Crescent Beaches & Colorful Towns
Starting in Panama City, Panama Canal Transit, Puerto Limon, Cruising the Caribbean Sea, Roatan, Harvest Caye, Santo Tomas De Castilla, Cozumel, Mexico, George Town, Montego Bay, Cruising the Straits of Florida, Miami
2027 Sails: Feb 22, More...
22 Night - Journey to the Amazon
Starting in Panama City, Panama Canal Transit, Cruising the Caribbean Sea, Oranjestad, Cruising the Caribbean Sea, Port of Spain, Cruising the Atlantic Ocean, Cruising the Amazon River, Manaus (Amazon River), Boca Da Valeria (Amazon River), Alter Do Chao (Amazon River), Cruising the Amazon River, Cruising the Atlantic Ocean, St Georges, Cruising the Caribbean Sea, Willemstad AN, Cruising the Caribbean Sea, Panama Canal Transit, Panama City
2027 Sails: Mar 9, More...10 Night - Panama & Pristine Isles
Starting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Santa Marta, Oranjestad, Willemstad AN, Port Antonio, Great Stirrup Cay, Miami
2027 Sails: Mar 15, More...
7 Night - Panama City / San Juan
Starting in Panama City, Transit Panama Canal, Guna Yala, San Blas Islands, Cartagena CO, Casa de Campo, San Juan
2027 Sails: Mar 28, More...14 Night - Carnival of Caribbean Colors
Starting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Santa Marta, Oranjestad, Willemstad AN, Bonaire (Kralendijk), Cruising the Caribbean Sea, St Georges, Castries, Gustavia, Tortola, Cruising the Atlantic Ocean, Cruising the Bahamian Waters, Miami
2027 Sails: Mar 31, More...
11 Night - Pristine Islands of the Caribbean & the Panama Canal
Starting in Panama City, Panama, Panama City / Panama Canal Transit, San Blas Islands, Lemon Cay, Panama, Cartagena CO, Cabo de La Vela, Colombia, Willemstad AN, Curacao, Tobago Cays, Grenadines, Mayreau, Grenadines, Soufriere, St Lucia, Bridgetown, Barbados
2027 Sails: Apr 3, More...
11 Night - A Journey of Mayan Discovery & Mexican Exploration
Starting in Panama City (Amador), Acajutla, Puerto Quetzal, Puerto Madero, Huatulco (Santa Maria Huatulco), Puerto Vallarta, Los Angeles
2027 Sails: Apr 22, More...
Cruises that depart from Central America: Panama: Panama City
Cruises that visit Panama City
Click on a cruise ship itinerary sailing from Panama City (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama City), please visit: Cruise Search or try our Virtual Cruise Advisor™.
10 Night - Classic Panama Canal PassageStarting in Panama City (Fuerte Amador), Scenic Sailing Panama Canal, Colon, Puerto Limon, Sail the Caribbean Sea, Roatan, Belize City, Cozumel, Mexico, Sail the Caribbean Sea, West Palm Beach, Florida
2026 Sails: Dec 17, More...
10 Night - Panama to Caribbean JoyStarting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Santa Marta, Oranjestad, Willemstad AN, Ocho Rios, Jamaica, George Town, Miami
2027 Sails: Jan 15, More...
28 Night - Canal to Coral ReefsStarting in Panama City, Cruising the Pacific Ocean, Puntarenas, Cruising the Pacific Ocean, Acajutla, Puerto Quetzal, Cruising the Pacific Ocean, Puerto Vallarta, Cabo San Lucas, Cruising the Pacific Ocean, Los Angeles, Cruising the Pacific Ocean, Honolulu, Kahului, Hilo, Cruising the Pacific Ocean, Bora Bora, Moorea, Papeete (Tahiti)
2027 Sails: Jan 26, More...
Deal link -> Special
11 Night - Crescent Beaches & Colorful TownsStarting in Panama City, Panama Canal Transit, Puerto Limon, Cruising the Caribbean Sea, Roatan, Harvest Caye, Santo Tomas De Castilla, Cozumel, Mexico, George Town, Montego Bay, Cruising the Straits of Florida, Miami
2027 Sails: Feb 22, More...
22 Night - Journey to the AmazonStarting in Panama City, Panama Canal Transit, Cruising the Caribbean Sea, Oranjestad, Cruising the Caribbean Sea, Port of Spain, Cruising the Atlantic Ocean, Cruising the Amazon River, Manaus (Amazon River), Boca Da Valeria (Amazon River), Alter Do Chao (Amazon River), Cruising the Amazon River, Cruising the Atlantic Ocean, St Georges, Cruising the Caribbean Sea, Willemstad AN, Cruising the Caribbean Sea, Panama Canal Transit, Panama City
2027 Sails: Mar 9, More...
10 Night - Panama & Pristine IslesStarting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Santa Marta, Oranjestad, Willemstad AN, Port Antonio, Great Stirrup Cay, Miami
2027 Sails: Mar 15, More...
7 Night - Panama City / San JuanStarting in Panama City, Transit Panama Canal, Guna Yala, San Blas Islands, Cartagena CO, Casa de Campo, San Juan
2027 Sails: Mar 28, More...
14 Night - Carnival of Caribbean ColorsStarting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Santa Marta, Oranjestad, Willemstad AN, Bonaire (Kralendijk), Cruising the Caribbean Sea, St Georges, Castries, Gustavia, Tortola, Cruising the Atlantic Ocean, Cruising the Bahamian Waters, Miami
2027 Sails: Mar 31, More...
11 Night - Pristine Islands of the Caribbean & the Panama CanalStarting in Panama City, Panama, Panama City / Panama Canal Transit, San Blas Islands, Lemon Cay, Panama, Cartagena CO, Cabo de La Vela, Colombia, Willemstad AN, Curacao, Tobago Cays, Grenadines, Mayreau, Grenadines, Soufriere, St Lucia, Bridgetown, Barbados
2027 Sails: Apr 3, More...
11 Night - A Journey of Mayan Discovery & Mexican ExplorationStarting in Panama City (Amador), Acajutla, Puerto Quetzal, Puerto Madero, Huatulco (Santa Maria Huatulco), Puerto Vallarta, Los Angeles
2027 Sails: Apr 22, More...
