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Mediterranean Cruise Departures

Cruises that depart from Mediterranean

Cruises that visit Mediterranean

See all River Cruises that depart from Mediterranean

Click on a cruise ship itinerary sailing from Mediterranean (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Mediterranean), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Croatia / Hrvatska : Cyprus : Egypt : Greece : Italy : Malta : Monaco : Slovenia : Turkey

Departing from
Mediterranean
Cruise Specials

Celebrity Cruises, Celebrity Constellation
Celebrity Constellation11 Night - Best of Italy & Croatia Cruise
Starting in Rome (Civitavecchia), Italy, Florence / Pisa (Livorno), Italy, Amalfi Coast (Salerno), Italy, Sicily (Messina), Italy, Kotor, Montenegro, Dubrovnik, Croatia, Split, Croatia, Zadar, Croatia, Ravenna, Italy
2026 Sails: Aug 31, More...
Queen Victoria7 Night - Central Mediterranean
Starting in Trieste, Italy, Zadar, Croatia, Dubrovnik, Croatia, Valletta, Malta, Palma De Mallorca, Spain, Barcelona, Spain
2026 Sails: Aug 31, More...
Queen Victoria14 Night - Adriatic and Western Mediterranean
Starting in Trieste, Italy, Zadar, Croatia, Dubrovnik, Croatia, Valletta, Malta, Palma De Mallorca, Spain, Barcelona, Spain, Ibiza, Spain, Ajaccio, Corsica, France, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Salerno (tours to Capri or Pompeii), Italy, Amalfi Coast Sail By, IT, Civitavecchia (tours to Rome), Italy
2026 Sails: Aug 31, More...
EXPLORA II7 Night - A Journey from Venetian Elegance to Stunning Nature & Tranquil Harbour Hues
Starting in Fusina (Venice), Rovinj, Dubrovnik, Croatia, Brindisi, Fiskardo (Cephalonia), Milos, Piraeus (Athens)
2026 Sails: Aug 31, More...
EXPLORA II14 Night - An Extended Journey from Adriatic Heritage to Aegean Grace
Starting in Fusina (Venice), Rovinj, Dubrovnik, Croatia, Brindisi, Fiskardo (Cephalonia), Milos, Piraeus (Athens), Bari, Nydri, Lefkada, Pylos, Katapola, Mykonos, Piraeus (Athens)
2026 Sails: Aug 31, More...
Viking Ocean, Viking Star
Viking Star12 Night - Mediterranean Odyssey
Starting in Venice (Chioggia), Split, Dubrovnik, Croatia, Corfu (Kerkyra), Sail the Ionian Sea, Naples, Rome (Civitavecchia), Florence / Pisa (Livorno), Monte Carlo, Marseille, Barcelona
2026 Sails: Aug 31, More...
Viking River Tours, Viking MS Antares Tours
Viking MS Antares Tours11 Night - Pharaohs & Pyramids
Starting in Cairo, Luxor, Qena, Luxor, Esna, Aswan, Kom Ombo, Edfu, Luxor, Cairo
2026 Sails: Aug 31, Sep 7, Sep 14, Sep 21, Sep 28, Oct 5, Oct 12, Oct 19, Oct 26, Nov 2, Nov 16, Nov 23, Nov 30, Dec 7, Dec 14, Dec 21, Dec 28, 2027: Jan 4, Jan 11, Jan 18, Feb 1, Feb 15, Feb 22, Mar 1, More...
Virgin Voyages, Scarlet Lady
Scarlet Lady10 Night - Mediterranean : Rome to Athens
Starting in Rome (Civitavecchia), Italy, Florence / Pisa (Livorno), Italy, Amalfi Coast (Salerno), Italy, Catania, Sicily, Italy, Chania (Souda Bay), Crete, Greece, Santorini, Greece, Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: Aug 31, More...
Sea Cloud, Sea Cloud II
Sea Cloud II7 Night - Back to Summer On the Azure Adriatic
Starting in Dubrovnik, Croatia, Komiza / Vis Island, Hvar, Korcula, Trogir, Rovinj, Venice
2026 Sails: Sep 1, More...
Sea Cloud, Sea Cloud Spirit
Sea Cloud Spirit8 Night - Emerald Coasts in the Late Summer
Starting in Olbia / Sardinia, Bonifacio / Corsica, Portoferraio / Elba, Calvi / Corsica, Alghero / Sardinia, Porto Cervo / Sardinia, Olbia / Sardinia
2026 Sails: Sep 1, More...

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Mediterranean Cruise Departures