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Mediterranean Cruise Departures

Cruises that depart from Mediterranean

Cruises that visit Mediterranean

See all River Cruises that depart from Mediterranean

Click on a cruise ship itinerary sailing from Mediterranean (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Mediterranean), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Croatia / Hrvatska : Cyprus : Egypt : Greece : Italy : Malta : Monaco : Slovenia : Turkey

Departing from
Mediterranean
Cruise Specials

Windstar Tours, Wind Spirit Tours
Wind Spirit Tours11 Night - Enchanting Meteora, Greece, and Amalfi Coast Cruise Tour
Starting in Rome, Sorrento, Messina (Taormina), Gythion, Monemvasia, Athens, Greece, Delphi, Athens, Greece
2026 Sails: Aug 27, More...
Celebrity Cruises, Celebrity Ascent
Celebrity Ascent10 Night - Italy, Greece & Croatia Cruise
Starting in Rome (Civitavecchia), Italy, Sicily (Messina), Italy, Olympia (Katakolon), Greece, Corfu, Greece, Montenegro, Split, Croatia, Dubrovnik, Croatia, Naples, Italy, Rome (Civitavecchia), Italy
2026 Sails: Aug 28, More...
Norwegian Cruise Line, Norwegian Viva
Norwegian Viva10 Night - Greek Isles & Italy
Starting in Venice (Ravenna), Italy, Dubrovnik, Croatia, Montenegro, Piraeus / Athens, Greece, Santorini Island, Greece, Rhodes, Greece, Kusadasi, Turkey, Thessaloniki, Greece, Istanbul, Turkey
2026 Sails: Aug 28, More...
Costa Cruise Lines, Costa Deliziosa
Costa Deliziosa14 Night - Eastern Mediterranean from Marghera
Starting in Marghera (Venice), Bari, Thira (Santorini), Mykonos, Katakolon (Olympia), Marghera (Venice), Bari, Corfu, Argostoli (Cephalonia), Dubrovnik, Croatia, Kotor, Zadar, Marghera (Venice)
2026 Sails: Aug 29, More...
Costa Cruise Lines, Costa Deliziosa
Costa Deliziosa7 Night - Eastern Mediterranean from Marghera
Starting in Marghera (Venice), Bari, Thira (Santorini), Mykonos, Katakolon (Olympia), Marghera (Venice)
2026 Sails: Aug 29, More...
Costa Cruise Lines, Costa Pacifica
Costa Pacifica3 Night - Southern Europe from Rome (Civitavecchia) to Palma De Mallorca
Starting in Civitavecchia (Rome), Savona, La Seyne (St Tropez), Palma De Mallorca
2026 Sails: Aug 29, More...
Holland America, Oosterdam
Oosterdam7 Night - Western Mediterranean
Starting in Civitavecchia (Rome), Italy, Portofino, Italy, Ajaccio, Corsica, France, Marseille (Provence), France, Gibraltar, Barcelona, Spain
2026 Sails: Aug 29, 2027: Jul 10, More...
PONANT, Le Dumont-d'Urville
Le Dumont-d'Urville8 Night - A Circumnavigation of Sicily - with Smithsonian Journeys
Starting in Valletta, Porto Empedocle, Sicily, Tunis, Trapani, Sicily, Palermo, Sicily, Lipari, Aeolian Islands, Sailing in front of Stromboli, Taormina, Sicily, Syracuse IT, Sicily, Valletta
2026 Sails: Aug 29, 2027: May 10, 2028: May 6, Oct 5, More...
SeaDream Yacht Club, SeaDream I
SeaDream I7 Night - Sorrentine Peninsula Sojourn Cruise
Starting in Rome (Civitavecchia), Bonifacio, Corsica, Ponza, Amalfi, Positano, Sorrento, Capri, Rome (Civitavecchia)
2026 Sails: Aug 29, More...
Star Clippers, Royal Clipper
Royal Clipper14 Night - Grand Voyage : Venice to Rome
Starting in Venice, Italy, Rovinj, Croatia, Sibenik, Croatia, Dubrovnik, Croatia, Kotor, Montenegro, Monopoli, Italy, Syracuse IT, Sicily, Italy, Lipari / Aeolian Islands, Italy, Sorrento, Italy, Ponza / Pontine Islands, Italy, Palmarola / Pontine Islands, Italy, Civitavecchia (Port for Rome), Italy, Saint-Florent / Corsica, France, Portoferraio / Elba, Italy, Civitavecchia (Port for Rome), Italy
2026 Sails: Aug 29, More...

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Mediterranean Cruise Departures