Colon Cruise Departures
Cruises that depart from Central America: Panama: Colon
Cruises that visit Colon
10 Night - From Panama's Wild Beauty to Peruvian Shores
Starting in Colon, San Blas Islands, Crossing the Panama Canal, Fuerte Amador, Flamenco Island, Playa Muerto, Darien National Park, Salaverry, Callao
2026 Sails: Oct 20, More...
7 Night - Central America Jewels & Panama Canal
Starting in Colon, San Blas Islands, Crossing the Panama Canal, Fuerte Amador, Flamenco Island, Playa Muerto, Darien National Park, Golfito, Puntarenas
2026 Sails: Nov 7, More...
10 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Kralendijk, Bonaire, Oranjestad, Aruba, Willemstad AN, Curacao, Port of Spain, Trinidad, Scarborough, Tobago, Colon, Panama
2026 Sails: Nov 14, More...10 Night - Secrets of Central America
Starting in Colon, Fort San Lorenzo (Colon), San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2026 Sails: Nov 21, 2027: Jan 14, More...
7 Night - Costa Rica & Panama Canal
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera
2026 Sails: Dec 5, Dec 19, 2027: Jan 2, More...10 Night - Monteverde Cloud Forest & Arenal Volcano Cruise Tour
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera, Santa Elena (Monteverde), La Fortuna (Arenal), Costa Rica, Puerto Caldera, San Jose, Costa Rica
2026 Sails: Dec 5, Dec 19, 2027: Jan 2, More...10 Night - Secrets of Central America
Starting in Colon, Fort San Lorenzo (Colon), San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2026 Sails: Dec 18, More...
10 Night - Secrets of Central America
Starting in Colon, Fort San Lorenzo (Colon), San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2026 Sails: Dec 19, More...7 Night - Southern Caribbean Holiday Cruise
Starting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Kralendijk, Bonaire, Colon, Panama
2026 Sails: Dec 19, More...
7 Night - Costa Rica & Panama Canal
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera
2027 Sails: Jan 5, Jan 19, Feb 2, More...
Cruises that depart from Central America: Panama: Colon
Cruises that visit Colon
Click on a cruise ship itinerary sailing from Colon (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Colon), please visit: Cruise Search or try our Virtual Cruise Advisor™.
10 Night - From Panama's Wild Beauty to Peruvian ShoresStarting in Colon, San Blas Islands, Crossing the Panama Canal, Fuerte Amador, Flamenco Island, Playa Muerto, Darien National Park, Salaverry, Callao
2026 Sails: Oct 20, More...
7 Night - Central America Jewels & Panama CanalStarting in Colon, San Blas Islands, Crossing the Panama Canal, Fuerte Amador, Flamenco Island, Playa Muerto, Darien National Park, Golfito, Puntarenas
2026 Sails: Nov 7, More...
10 Night - Southern Caribbean CruiseStarting in Colon, Panama, Kralendijk, Bonaire, Oranjestad, Aruba, Willemstad AN, Curacao, Port of Spain, Trinidad, Scarborough, Tobago, Colon, Panama
2026 Sails: Nov 14, More...
10 Night - Secrets of Central AmericaStarting in Colon, Fort San Lorenzo (Colon), San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2026 Sails: Nov 21, 2027: Jan 14, More...
7 Night - Costa Rica & Panama CanalStarting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera
2026 Sails: Dec 5, Dec 19, 2027: Jan 2, More...
10 Night - Monteverde Cloud Forest & Arenal Volcano Cruise TourStarting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera, Santa Elena (Monteverde), La Fortuna (Arenal), Costa Rica, Puerto Caldera, San Jose, Costa Rica
2026 Sails: Dec 5, Dec 19, 2027: Jan 2, More...
10 Night - Secrets of Central AmericaStarting in Colon, Fort San Lorenzo (Colon), San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2026 Sails: Dec 18, More...
10 Night - Secrets of Central AmericaStarting in Colon, Fort San Lorenzo (Colon), San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2026 Sails: Dec 19, More...
7 Night - Southern Caribbean Holiday CruiseStarting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Kralendijk, Bonaire, Colon, Panama
2026 Sails: Dec 19, More...
7 Night - Costa Rica & Panama CanalStarting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera
2027 Sails: Jan 5, Jan 19, Feb 2, More...
