Colon Cruise Departures
Cruises that depart from Central America: Panama: Colon
Cruises that visit Colon
7 Night - Costa Rica & Panama Canal
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera
2026 Sails: Feb 9, Feb 23, More...
19 Night - Star Collector : Caribbean Cultures : Latin America & the Greater Antilles
Starting in Colon, Bocas del Toro, Isla San Andres, Roatan, Belize City, Costa Maya, Mexico, Cozumel, Mexico, Grand Cayman, Cayman Brac, Ocho Rios, Jamaica, Santo Domingo, La Romana, Jost Van Dyke, Great Harbour, Virgin Gorda / Prickly Pear, British Virgin Islands, Philipsburg, St Maarten
2026 Sails: Feb 9, More...8 Night - James Beard Foundation : Mayan Legacies
Starting in Colon, Bocas del Toro, Isla San Andres, Roatan, Belize City, Costa Maya, Mexico, Cozumel, Mexico
2026 Sails: Feb 9, More...
7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama
2026 Sails: Feb 14, Mar 21, Apr 4, More...
13 Night - Cruise from Colon to Puntarenas
Starting in Colon, San Blas Islands, Transit Panama Canal, Pearl Islands, Puerto Jimenez, Playa Mantas / Punta Leona, Quepos, Marina Flamingo / Playa Flamingo, Playa Panama, Puntarenas
2026 Sails: Feb 17, More...
7 Night - Panama and Costa Rica by Sea : the Natural Wonders of Central America - with Smithsonian Journeys
Starting in Colon, San Blas Islands, Crossing the Panama Canal, Playa Muerto, Darien National Park, Fuerte Amador, Flamenco Island, Quepos, Puntarenas
2026 Sails: Feb 19, More...10 Night - Secrets of Central America
Starting in Colon, Fort San Lorenzo (Colon), Colon, San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Cebaco Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2026 Sails: Mar 5, More...6 Night - Panama's Pristine Caribbean
Starting in Colon, Bocas del Toro, San Blas, Panama, Cartagena CO, Oranjestad
2026 Sails: Mar 9, More...7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Willemstad AN, Curacao, Oranjestad, Aruba, Colon, Panama
2026 Sails: Mar 14, Apr 11, More...12 Night - Panama, Colombia & Caribbean Islands
Starting in Colon, Portobelo, San Blas Islands, Cartagena, Santa Marta, Bonaire, Mayreau Island, Union Island, Pigeon Island Beach, Soufriere, Les Saintes, Fort-de-France
2026 Sails: Mar 25, More...
Cruises that depart from Central America: Panama: Colon
Cruises that visit Colon
Click on a cruise ship itinerary sailing from Colon (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Colon), please visit: Cruise Search or try our Virtual Cruise Advisor™.
7 Night - Costa Rica & Panama CanalStarting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera
2026 Sails: Feb 9, Feb 23, More...
19 Night - Star Collector : Caribbean Cultures : Latin America & the Greater AntillesStarting in Colon, Bocas del Toro, Isla San Andres, Roatan, Belize City, Costa Maya, Mexico, Cozumel, Mexico, Grand Cayman, Cayman Brac, Ocho Rios, Jamaica, Santo Domingo, La Romana, Jost Van Dyke, Great Harbour, Virgin Gorda / Prickly Pear, British Virgin Islands, Philipsburg, St Maarten
2026 Sails: Feb 9, More...
8 Night - James Beard Foundation : Mayan LegaciesStarting in Colon, Bocas del Toro, Isla San Andres, Roatan, Belize City, Costa Maya, Mexico, Cozumel, Mexico
2026 Sails: Feb 9, More...
7 Night - Southern Caribbean CruiseStarting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama
2026 Sails: Feb 14, Mar 21, Apr 4, More...
13 Night - Cruise from Colon to PuntarenasStarting in Colon, San Blas Islands, Transit Panama Canal, Pearl Islands, Puerto Jimenez, Playa Mantas / Punta Leona, Quepos, Marina Flamingo / Playa Flamingo, Playa Panama, Puntarenas
2026 Sails: Feb 17, More...
7 Night - Panama and Costa Rica by Sea : the Natural Wonders of Central America - with Smithsonian JourneysStarting in Colon, San Blas Islands, Crossing the Panama Canal, Playa Muerto, Darien National Park, Fuerte Amador, Flamenco Island, Quepos, Puntarenas
2026 Sails: Feb 19, More...
10 Night - Secrets of Central AmericaStarting in Colon, Fort San Lorenzo (Colon), Colon, San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Cebaco Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2026 Sails: Mar 5, More...
6 Night - Panama's Pristine CaribbeanStarting in Colon, Bocas del Toro, San Blas, Panama, Cartagena CO, Oranjestad
2026 Sails: Mar 9, More...
7 Night - Southern Caribbean CruiseStarting in Colon, Panama, Cartagena CO, Willemstad AN, Curacao, Oranjestad, Aruba, Colon, Panama
2026 Sails: Mar 14, Apr 11, More...
12 Night - Panama, Colombia & Caribbean IslandsStarting in Colon, Portobelo, San Blas Islands, Cartagena, Santa Marta, Bonaire, Mayreau Island, Union Island, Pigeon Island Beach, Soufriere, Les Saintes, Fort-de-France
2026 Sails: Mar 25, More...
