Colon Cruise Departures
Cruises that depart from Central America: Panama: Colon
Cruises that visit Colon
13 Night - Central America from Colon to Cozumel
Starting in Colon, San Blas Islands, Bocas del Toro, Puerto Limon, Isla Guanaja, French Key / Islas De La Bahia, Belize City, Lighthouse Reef / Half Moon Caye, Cozumel, Mexico
2026 Sails: Mar 13, More...
7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Willemstad AN, Curacao, Oranjestad, Aruba, Colon, Panama
2026 Sails: Mar 14, Apr 11, More...
12 Night - Panama, Colombia & Caribbean Islands
Starting in Colon, Portobelo, San Blas Islands, Cartagena, Santa Marta, Bonaire, Mayreau Island, Union Island, Pigeon Island Beach, Soufriere, Les Saintes, Fort-de-France
2026 Sails: Mar 25, More...7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Kralendijk, Bonaire, Colon, Panama
2026 Sails: Mar 28, More...
15 Night - Star Collector : Panama Canal, Costa Rica & Mexican Riviera Discovery
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera, Curu, Costa Rica, Playas del Coco, Puerto Chiapas, Huatulco, Manzanillo, Puerto Vallarta
2026 Sails: Apr 13, More...7 Night - Costa Rica & Panama Canal
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera
2026 Sails: Apr 13, More...1 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO
2026 Sails: Apr 18, More...10 Night - Panama Canal Westward Cruise
Starting in Colon, Panama, Panama Canal (Cruising), Puntarenas, Costa Rica, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2026 Sails: Apr 25, More...
7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama
2026 Sails: May 9, May 16, May 23, May 30, Jun 6, Jun 13, Jun 20, Jun 27, Jul 4, Jul 11, Jul 18, Jul 25, Aug 1, Aug 8, Aug 15, Aug 22, Aug 29, Sep 12, Sep 19, Sep 26, Oct 3, Oct 10, Oct 17, Oct 24, More...7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Kralendijk, Bonaire, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama
2026 Sails: Sep 5, More...
Cruises that depart from Central America: Panama: Colon
Cruises that visit Colon
Click on a cruise ship itinerary sailing from Colon (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Colon), please visit: Cruise Search or try our Virtual Cruise Advisor™.
13 Night - Central America from Colon to CozumelStarting in Colon, San Blas Islands, Bocas del Toro, Puerto Limon, Isla Guanaja, French Key / Islas De La Bahia, Belize City, Lighthouse Reef / Half Moon Caye, Cozumel, Mexico
2026 Sails: Mar 13, More...
7 Night - Southern Caribbean CruiseStarting in Colon, Panama, Cartagena CO, Willemstad AN, Curacao, Oranjestad, Aruba, Colon, Panama
2026 Sails: Mar 14, Apr 11, More...
12 Night - Panama, Colombia & Caribbean IslandsStarting in Colon, Portobelo, San Blas Islands, Cartagena, Santa Marta, Bonaire, Mayreau Island, Union Island, Pigeon Island Beach, Soufriere, Les Saintes, Fort-de-France
2026 Sails: Mar 25, More...
7 Night - Southern Caribbean CruiseStarting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Kralendijk, Bonaire, Colon, Panama
2026 Sails: Mar 28, More...
15 Night - Star Collector : Panama Canal, Costa Rica & Mexican Riviera DiscoveryStarting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera, Curu, Costa Rica, Playas del Coco, Puerto Chiapas, Huatulco, Manzanillo, Puerto Vallarta
2026 Sails: Apr 13, More...
7 Night - Costa Rica & Panama CanalStarting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera
2026 Sails: Apr 13, More...
1 Night - Southern Caribbean CruiseStarting in Colon, Panama, Cartagena CO
2026 Sails: Apr 18, More...
10 Night - Panama Canal Westward CruiseStarting in Colon, Panama, Panama Canal (Cruising), Puntarenas, Costa Rica, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2026 Sails: Apr 25, More...
7 Night - Southern Caribbean CruiseStarting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama
2026 Sails: May 9, May 16, May 23, May 30, Jun 6, Jun 13, Jun 20, Jun 27, Jul 4, Jul 11, Jul 18, Jul 25, Aug 1, Aug 8, Aug 15, Aug 22, Aug 29, Sep 12, Sep 19, Sep 26, Oct 3, Oct 10, Oct 17, Oct 24, More...
7 Night - Southern Caribbean CruiseStarting in Colon, Panama, Cartagena CO, Kralendijk, Bonaire, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama
2026 Sails: Sep 5, More...
