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Colombia Cruise Departures

Cruises that depart from South America: Colombia

Cruises that visit Colombia

See all River Cruises that depart from Colombia

Click on a cruise ship itinerary sailing from Colombia (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Colombia), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Barranquilla : Cartagena CO : Medellin

Departing from
Colombia
Cruise Specials

AmaWaterways, AmaMagdalena
AmaMagdalena7 Night - Magic of Colombia
Starting in Barranquilla, San Felipe, Magangue, Mompox, Calamar, Manzini, Cartagena CO, Colombia
2026 Sails: Jun 13, More...
Royal Caribbean, Grandeur of the Seas
Grandeur of the Seas7 Night - Southern Caribbean Cruise
Starting in Cartagena CO, Kralendijk, Bonaire, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama, Cartagena CO
2026 Sails: Sep 6, More...
Lindblad Expeditions, National Geographic Quest
National Geographic Quest7 Night - Panama and Colombia : Exploring the Caribbean Coast
Starting in Cartagena CO, Colombia / Embark Ship, Sanguare Natural Reserve / Cispata Bay, San Antero / Santa Cruz de Lorica / Tuchin, Capurgana and Sapzurro, Colombia, Guna Yala Archipelago, Portobelo, Gatun Lake, Panama City, Panama / Disembark Ship
2026 Sails: Nov 7, More...
Royal Caribbean, Grandeur of the Seas
Grandeur of the Seas6 Night - Southern Caribbean Cruise
Starting in Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama
2026 Sails: Nov 8, 2027: Apr 18, More...
Crystal Cruises, Crystal Serenity
Crystal Serenity10 Night - The Americas & Caribbean
Starting in Cartagena CO, Willemstad AN, Kralendijk, Oranjestad, Aruba, Santa Marta, Panama Canal Transit, Fuerte Amador (Panama City), Puerto Caldera
2026 Sails: Dec 2, More...
Royal Caribbean, Grandeur of the Seas
Grandeur of the Seas7 Night - Southern Caribbean Holiday
Starting in Cartagena CO, Oranjestad, Aruba, Kralendijk, Bonaire, Colon, Panama, Cartagena CO
2026 Sails: Dec 20, More...
AmaWaterways, AmaMagdalena
AmaMagdalena7 Night - Wonders of Colombia
Starting in Cartagena CO, Gambote / Palenque, Calamar, Santa Barbara de Pinto, Mompox, Magangue, Sitionuevo, Barranquilla
2027 Sails: Jan 2, Jan 16, Jan 30, Feb 27, Mar 13, Mar 27, Apr 10, Apr 24, May 8, Sep 11, Oct 23, Nov 6, Nov 20, Dec 4, Dec 18, More...
AmaWaterways Tours, AmaMelodia Tours
AmaMelodia Tours10 Night - Magic of Colombia with Medellin Pre Cruise
Starting in Medellin, Barranquilla, Medellin, San Felipe, Mompox, Magangue, Calamar, Cartagena CO, Colombia
2027 Sails: Jan 3, Jan 17, Jan 31, Feb 14, Mar 14, Mar 28, Apr 11, May 9, May 23, Jun 6, Aug 29, Sep 12, Sep 26, Oct 10, Oct 24, Nov 7, Nov 21, Dec 5, Dec 19, More...
AmaWaterways Tours, AmaMelodia Tours
AmaMelodia Tours13 Night - Magic of Colombia with in Medellin Pre Cruise and in Panama City Post Cruise
Starting in Medellin, Barranquilla, Medellin, San Felipe, Mompox, Magangue, Calamar, Cartagena CO, Colombia, Panama City
2027 Sails: Jan 3, Jan 17, Jan 31, Feb 14, Mar 14, Mar 28, Apr 11, May 9, May 23, Jun 6, Aug 29, Sep 12, Sep 26, Oct 10, Oct 24, Nov 7, Nov 21, Dec 5, Dec 19, More...
AmaWaterways, AmaMelodia
AmaMelodia7 Night - Magic of Colombia
Starting in Barranquilla, Sitionuevo, Santa Barbara de Pinto, Mompox, Magangue, Calamar, Cartagena CO
2027 Sails: Jan 6, Jan 20, Feb 3, Feb 17, Mar 17, Mar 31, Apr 14, May 12, May 26, Jun 9, Sep 1, Sep 15, Sep 29, Oct 13, Oct 27, Nov 10, Nov 24, Dec 8, Dec 22, More...

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Colombia Cruise Departures