South America Cruises
Cruises that visit South America
Cruises by region
See all South America River Cruises
Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : Suriname : Uruguay
15 Night - Galapagos by Catamaran, Machu Picchu and Peru's Land of the Inca
Starting in Quito or Guayaquil, Ecuador, Quito or Guayaquil / Galapagos Islands / Embark Ship, Galapagos Islands, Galapagos Islands / Disembark Ship / Guayaquil / Lima, Peru, Lima, Lima / Cusco / Sacred Valley, Sacred Valley, Sacred Valley / Machu Picchu, Machu Picchu / Cusco, Cusco, Cusco / Lima
2026 Sails: Jan 2, Jan 9, Jan 16, Jan 23, Jan 30, Feb 6, Feb 13, Feb 20, Feb 27, Mar 6, Mar 20, Mar 27, Apr 3, Apr 10, Apr 17, Apr 24, May 22, May 29, Jun 5, Jun 26, Jul 3, Jul 10, Jul 17, Jul 24, More...9 Night - Galapagos by Catamaran : An Intimate Voyage
Starting in Quito or Guayaquil, Ecuador, Quito or Guayaquil, Galapagos Islands, Galapagos Islands, Galapagos Islands / Disembark Ship / Guayaquil or Quito, Guayaquil or Quito
2026 Sails: Jan 2, Jan 9, Jan 16, Jan 23, Jan 30, Feb 6, Feb 13, Feb 20, Feb 27, Mar 6, Mar 20, Mar 27, Apr 3, Apr 10, Apr 17, Apr 24, May 22, May 29, Jun 5, Jun 26, Jul 3, Jul 10, Jul 17, Jul 24, More...
9 Night - Exploring Galapagos
Starting in Quito or Guayaquil, Ecuador, Quito or Guayaquil, Galapagos Islands, Galapagos Islands, Galapagos Islands / Disembark Ship / Guayaquil or Quito, Guayaquil or Quito
2026 Sails: Jan 2, Jan 9, Jan 16, Jan 23, Jan 30, Feb 6, Feb 13, Feb 20, Feb 27, Mar 6, Mar 13, Mar 20, Mar 27, Apr 3, Apr 10, Apr 17, Apr 24, May 1, May 8, May 15, May 22, May 29, Jun 5, Jun 12, More...15 Night - Exploring Galapagos, Machu Picchu and Peru's Land of the Inca
Starting in Quito or Guayaquil, Ecuador, Guayaquil / Galapagos Islands / Embark Ship, Galapagos Islands, Galapagos Islands / Disembark Ship / Guayaquil / Lima, Peru, Lima, Lima / Cusco / Sacred Valley, Sacred Valley, Sacred Valley / Machu Picchu, Machu Picchu / Cusco, Cusco, Cusco / Lima
2026 Sails: Jan 2, Jan 9, Jan 16, Jan 23, Jan 30, Feb 6, Feb 13, Feb 20, Feb 27, Mar 6, Mar 13, Mar 20, Mar 27, Apr 3, Apr 10, Apr 17, Apr 24, May 1, May 8, May 15, May 22, May 29, Jun 5, Jun 12, More...
15 Night - Exploring Galapagos, Machu Picchu and Peru's Land of the Inca
Starting in Quito or Guayaquil, Ecuador, Guayaquil / Galapagos Islands / Embark Ship, Galapagos Islands, Galapagos Islands / Disembark Ship / Guayaquil / Lima, Peru, Lima, Lima / Cusco / Sacred Valley, Sacred Valley, Sacred Valley / Machu Picchu, Machu Picchu / Cusco, Cusco, Cusco / Lima
2026 Sails: Jan 2, Jan 9, Jan 16, Jan 23, Jan 30, Feb 6, Feb 13, Feb 20, Feb 27, Mar 6, Mar 13, Mar 20, Mar 27, Apr 3, Apr 10, Apr 17, Apr 24, May 1, May 8, May 15, May 22, May 29, Jun 5, Jun 12, More...9 Night - Exploring Galapagos
Starting in Quito or Guayaquil, Ecuador, Quito or Guayaquil, Galapagos Islands, Galapagos Islands, Galapagos Islands / Disembark Ship / Guayaquil or Quito, Guayaquil or Quito
2026 Sails: Jan 2, Jan 9, Jan 16, Jan 23, Jan 30, Feb 6, Feb 13, Feb 20, Feb 27, Mar 6, Mar 13, Mar 20, Mar 27, Apr 3, Apr 10, Apr 17, Apr 24, May 1, May 8, May 15, May 22, May 29, Jun 5, Jun 12, More...
8 Night - Antarctica Direct : Fly the Drake Passage
Starting in Puerto Natales, Chile, Puerto Natales / King George Island, Antarctica / Embark Ship, Antarctica, King George Island / Disembark Ship / Puerto Natales, Puerto Natales
2026 Sails: Jan 2, Jan 26, Feb 18, Nov 19, Nov 25, Dec 27, 2027: Jan 2, Jan 8, Jan 19, Jan 25, Jan 31, Feb 6, Nov 22, Nov 28, Dec 4, Dec 21, Dec 27, 2028: Jan 2, Jan 8, Jan 19, Jan 25, Jan 31, Feb 6, Feb 17, More...
6 Night - Southwestern Darwin's Legacy Southwestern Roundtrip from Baltra & North Seymour Islands
Starting in Baltra Island / North Seymour, Isabela and Fernandina Islands, Urbina Bay and Tagus Cove, Rabida and Santa Cruz Islands, Santa Cruz Island, Floreana Island, Baltra Island
2026 Sails: Jan 2, Jan 16, Jan 30, Feb 13, Feb 27, Mar 13, Mar 27, Apr 10, Apr 24, May 8, May 22, Jun 5, Jun 19, Jul 3, Jul 17, Jul 31, Aug 14, Aug 28, Sep 11, Sep 25, Oct 9, Oct 23, Nov 6, Nov 20, More...
11 Night - Panama Canal - Miami
Starting in Miami, Fl, Ocho Rios, Jamaica, Cartagena CO, Panama Canal Gatun Lake, Panama, Colon, Panama, Puerto Limon, Costa Rica, Harvest Caye, Belize, Cozumel, Mexico, Miami, Fl
2026 Sails: Jan 2, More...
14 Night - Antarctica Cruise
Starting in Buenos Aires, Argentina, Ushuaia, Argentina, Cape Horn, Chile, Schollaert Channel, Antarctica, Paradise Bay, Antarctica, Gerlache Strait, Elephant Island, Antarctica, Port Stanley, Falkland Islands, Puerto Madryn, Argentina, Montevideo, Uruguay, Buenos Aires, Argentina
2026 Sails: Jan 3, Jan 17, 2027: Jan 2, Jan 16, Jan 30, 2028: Jan 2, Jan 16, Jan 30, More...
Cruises that visit South America
Cruises by region
See all South America River Cruises
Click on a cruise ship itinerary in South America (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just South America), please visit: Cruise Search or try our Virtual Cruise Advisor™.
Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : Suriname : Uruguay
15 Night - Galapagos by Catamaran, Machu Picchu and Peru's Land of the IncaStarting in Quito or Guayaquil, Ecuador, Quito or Guayaquil / Galapagos Islands / Embark Ship, Galapagos Islands, Galapagos Islands / Disembark Ship / Guayaquil / Lima, Peru, Lima, Lima / Cusco / Sacred Valley, Sacred Valley, Sacred Valley / Machu Picchu, Machu Picchu / Cusco, Cusco, Cusco / Lima
2026 Sails: Jan 2, Jan 9, Jan 16, Jan 23, Jan 30, Feb 6, Feb 13, Feb 20, Feb 27, Mar 6, Mar 20, Mar 27, Apr 3, Apr 10, Apr 17, Apr 24, May 22, May 29, Jun 5, Jun 26, Jul 3, Jul 10, Jul 17, Jul 24, More...
9 Night - Galapagos by Catamaran : An Intimate VoyageStarting in Quito or Guayaquil, Ecuador, Quito or Guayaquil, Galapagos Islands, Galapagos Islands, Galapagos Islands / Disembark Ship / Guayaquil or Quito, Guayaquil or Quito
2026 Sails: Jan 2, Jan 9, Jan 16, Jan 23, Jan 30, Feb 6, Feb 13, Feb 20, Feb 27, Mar 6, Mar 20, Mar 27, Apr 3, Apr 10, Apr 17, Apr 24, May 22, May 29, Jun 5, Jun 26, Jul 3, Jul 10, Jul 17, Jul 24, More...
9 Night - Exploring GalapagosStarting in Quito or Guayaquil, Ecuador, Quito or Guayaquil, Galapagos Islands, Galapagos Islands, Galapagos Islands / Disembark Ship / Guayaquil or Quito, Guayaquil or Quito
2026 Sails: Jan 2, Jan 9, Jan 16, Jan 23, Jan 30, Feb 6, Feb 13, Feb 20, Feb 27, Mar 6, Mar 13, Mar 20, Mar 27, Apr 3, Apr 10, Apr 17, Apr 24, May 1, May 8, May 15, May 22, May 29, Jun 5, Jun 12, More...
15 Night - Exploring Galapagos, Machu Picchu and Peru's Land of the IncaStarting in Quito or Guayaquil, Ecuador, Guayaquil / Galapagos Islands / Embark Ship, Galapagos Islands, Galapagos Islands / Disembark Ship / Guayaquil / Lima, Peru, Lima, Lima / Cusco / Sacred Valley, Sacred Valley, Sacred Valley / Machu Picchu, Machu Picchu / Cusco, Cusco, Cusco / Lima
2026 Sails: Jan 2, Jan 9, Jan 16, Jan 23, Jan 30, Feb 6, Feb 13, Feb 20, Feb 27, Mar 6, Mar 13, Mar 20, Mar 27, Apr 3, Apr 10, Apr 17, Apr 24, May 1, May 8, May 15, May 22, May 29, Jun 5, Jun 12, More...
15 Night - Exploring Galapagos, Machu Picchu and Peru's Land of the IncaStarting in Quito or Guayaquil, Ecuador, Guayaquil / Galapagos Islands / Embark Ship, Galapagos Islands, Galapagos Islands / Disembark Ship / Guayaquil / Lima, Peru, Lima, Lima / Cusco / Sacred Valley, Sacred Valley, Sacred Valley / Machu Picchu, Machu Picchu / Cusco, Cusco, Cusco / Lima
2026 Sails: Jan 2, Jan 9, Jan 16, Jan 23, Jan 30, Feb 6, Feb 13, Feb 20, Feb 27, Mar 6, Mar 13, Mar 20, Mar 27, Apr 3, Apr 10, Apr 17, Apr 24, May 1, May 8, May 15, May 22, May 29, Jun 5, Jun 12, More...
9 Night - Exploring GalapagosStarting in Quito or Guayaquil, Ecuador, Quito or Guayaquil, Galapagos Islands, Galapagos Islands, Galapagos Islands / Disembark Ship / Guayaquil or Quito, Guayaquil or Quito
2026 Sails: Jan 2, Jan 9, Jan 16, Jan 23, Jan 30, Feb 6, Feb 13, Feb 20, Feb 27, Mar 6, Mar 13, Mar 20, Mar 27, Apr 3, Apr 10, Apr 17, Apr 24, May 1, May 8, May 15, May 22, May 29, Jun 5, Jun 12, More...
8 Night - Antarctica Direct : Fly the Drake PassageStarting in Puerto Natales, Chile, Puerto Natales / King George Island, Antarctica / Embark Ship, Antarctica, King George Island / Disembark Ship / Puerto Natales, Puerto Natales
2026 Sails: Jan 2, Jan 26, Feb 18, Nov 19, Nov 25, Dec 27, 2027: Jan 2, Jan 8, Jan 19, Jan 25, Jan 31, Feb 6, Nov 22, Nov 28, Dec 4, Dec 21, Dec 27, 2028: Jan 2, Jan 8, Jan 19, Jan 25, Jan 31, Feb 6, Feb 17, More...
6 Night - Southwestern Darwin's Legacy Southwestern Roundtrip from Baltra & North Seymour IslandsStarting in Baltra Island / North Seymour, Isabela and Fernandina Islands, Urbina Bay and Tagus Cove, Rabida and Santa Cruz Islands, Santa Cruz Island, Floreana Island, Baltra Island
2026 Sails: Jan 2, Jan 16, Jan 30, Feb 13, Feb 27, Mar 13, Mar 27, Apr 10, Apr 24, May 8, May 22, Jun 5, Jun 19, Jul 3, Jul 17, Jul 31, Aug 14, Aug 28, Sep 11, Sep 25, Oct 9, Oct 23, Nov 6, Nov 20, More...
11 Night - Panama Canal - MiamiStarting in Miami, Fl, Ocho Rios, Jamaica, Cartagena CO, Panama Canal Gatun Lake, Panama, Colon, Panama, Puerto Limon, Costa Rica, Harvest Caye, Belize, Cozumel, Mexico, Miami, Fl
2026 Sails: Jan 2, More...
14 Night - Antarctica CruiseStarting in Buenos Aires, Argentina, Ushuaia, Argentina, Cape Horn, Chile, Schollaert Channel, Antarctica, Paradise Bay, Antarctica, Gerlache Strait, Elephant Island, Antarctica, Port Stanley, Falkland Islands, Puerto Madryn, Argentina, Montevideo, Uruguay, Buenos Aires, Argentina
2026 Sails: Jan 3, Jan 17, 2027: Jan 2, Jan 16, Jan 30, 2028: Jan 2, Jan 16, Jan 30, More...
