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South America Cruises

Cruises that visit South America

Cruises by region

See all South America River Cruises

Click on a cruise ship itinerary in South America (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just South America), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : South Georgia / South Sandwich Islands : Uruguay



MSC Cruises, MSC Splendida
MSC Splendida18 Night - Msc Grand Voyages
Starting in Barcelona, Spain, Gibraltar, Casablanca (Marrakesh), Morocco, Las Palmas de Gran Canaria (Canary Islands), Spain, Maceio, Brazil, Salvador, Brazil, Rio De Janeiro, Brazil, Montevideo, Uruguay, Buenos Aires, Argentina
2026 Sails: Nov 15, More...
MSC Cruises, MSC Splendida
MSC Splendida14 Night - Msc Grand Voyages
Starting in Barcelona, Spain, Gibraltar, Casablanca (Marrakesh), Morocco, Las Palmas de Gran Canaria (Canary Islands), Spain, Maceio, Brazil, Salvador, Brazil, Rio De Janeiro, Brazil
2026 Sails: Nov 15, More...
AmaWaterways Tours, AmaMelodia Tours
AmaMelodia Tours9 Night - Wonders of Colombia with in Cartagena Pre Cruise
Starting in Cartagena CO, Colombia, Mahates, Calamar, Magangue, Mompox, Santa Barbara de Pinto, Sitionuevo, Barranquilla
2026 Sails: Nov 16, Nov 30, Dec 14, More...
HX Expeditions Tours, MS Santa Cruz II Tours
MS Santa Cruz II Tours4 Night - Galapagos from Quito to Guayaquil
Starting in Quito Airport, Seymour, Las Bachas, Santa Cruz Island, Buccaneer Cove, Puerto Egas, Rabida Island, Bartolome Island, Prince Philip Steps, Genovesa Island, Darwin Bay, Genovesa Island, Itabaca Channel, Seymour, Baltra Airport (Galapagos)
2026 Sails: Nov 16, Nov 30, Dec 14, Dec 28, More...
Metropolitan Touring, La Pinta
La Pinta4 Night - Northeastern Origin of Species Adventure Roundtrip from Santa Cruz & Baltra Islands
Starting in Santa Cruz Island / Baltra Island, Santa Cruz and Chinese Hat Islet, Bartolome and Santiago Islands, Genovesa Island, Baltra Island
2026 Sails: Nov 16, Nov 30, Dec 14, Dec 28, 2027: Jan 11, Jan 25, Feb 8, Feb 22, Mar 8, Mar 22, Apr 5, Apr 19, May 3, May 17, May 31, Jun 14, Jun 28, Jul 12, Jul 26, Aug 9, Aug 23, Sep 6, Sep 20, Oct 4, More...
MSC Cruises, MSC Musica
MSC Musica4 Night - South America
Starting in Santos (Sao Paulo), Brazil, Ilha Grande, Brazil, Ilhabela, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Nov 16, More...
Explora Journeys, EXPLORA I
EXPLORA I18 Night - An Extended Journey Through Caribbean Beauty & Ocean Stillness
Starting in Miami, Merida (Progreso), Roatan Island, Belize City, Ocean Cay, Miami, Willemstad AN, Oranjestad, Santa Marta, Cartagena CO, George Town, Grand Cayman, Miami
2026 Sails: Nov 17, More...
PONANT, Le Lyrial
Le Lyrial17 Night - The Great Austral Loop
Starting in Ushuaia, Grave Cove, The Neck, Saunders Island, South Georgia, Antarctic Peninsula, Crossing the Drake Passage, Ushuaia
2026 Sails: Nov 17, More...
AmaWaterways, AmaMelodia
AmaMelodia7 Night - Wonders of Colombia
Starting in Cartagena CO, Palenque, Calamar, Magangue, Mompox, Santa Barbara de Pinto, Sitionuevo, Barranquilla
2026 Sails: Nov 18, Dec 2, Dec 16, Dec 30, 2028: Aug 9, Nov 1, More...
AmaWaterways Tours, AmaMelodia Tours
AmaMelodia Tours10 Night - Wonders of Colombia with in Panama City Post Cruise
Starting in Cartagena CO, Colombia, Mahates, Calamar, Magangue, Mompox, Santa Barbara de Pinto, Sitionuevo, Barranquilla, Panama City
2026 Sails: Nov 18, Dec 2, Dec 16, More...

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South America Cruises