Santa Cruz Island Cruises
Cruises that visit South America: Ecuador: Galapagos Islands: Santa Cruz Island
Cruises that depart from Santa Cruz Island
See all River Cruises that visit Santa Cruz Island
7 Night - Galapagos Outer Loop Cruise
Starting in Baltra (Galapagos), Gardner Bay (Espanola), Suarez Point, (Espanola), Cormorant Point (Floreana), Bahia Post Office (Floreana), Moreno Point (Isabela), Urbina Bay (Isabela), Espinoza Point, (Fernandina), Vicente Roca Point (Isabela), South Plaza (Santa Cruz Island), Daphne Island, Dragon Hill (Santa Cruz Island), Puerto Ayora, Santa Cruz Island, Baltra (Galapagos)
2026 Sails: Jan 11, Feb 8, Feb 22, Mar 8, May 3, May 31, Jun 14, Jun 28, Jul 12, Jul 26, Aug 9, Aug 23, Sep 6, Sep 20, Oct 4, Oct 18, Nov 1, Nov 15, Nov 29, Dec 13, Dec 27, 2027: Jan 10, Jan 24, Feb 7, More...11 Night - Quito & Galapagos Inner Loop
Starting in Quito, Ecuador, Quito to Baltra Embarkation, Baltra Island (Galapagos), Egas Port, Santiago Island, Rabida Island, Elizabeth Bay, Tagus Cove, Isabela Island, Sullivan Bay (Santiago Island), Bartolome Island, Las Bachas, Santa Cruz Island, Daphne Major / Cruising, North Seymour Island, Puerto Baquerizo Moreno, San Cristobal Island, Punta Pitt, San Cristobal Island, Puerto Ayora, Santa Cruz Island, Baltra Island (Galapagos), Baltra / Quito Disembarkation, Quito, Ecuador
2026 Sails: Jan 16, Jan 30, Feb 13, Feb 27, Apr 10, Jun 5, Jun 19, Jul 3, Jul 17, Jul 31, Aug 14, Aug 28, Sep 11, Sep 25, Oct 9, Oct 23, Nov 6, Nov 20, Dec 4, Dec 18, 2027: Jan 1, Jan 15, Jan 29, Feb 12, More...10 Night - Quito & Galapagos Inner Loop
Starting in Quito, Ecuador, Quito to Baltra Embarkation, Baltra Island (Galapagos), Egas Port, Santiago Island, Rabida Island, Elizabeth Bay, Tagus Cove, Isabela Island, Sullivan Bay (Santiago Island), Bartolome Island, Las Bachas, Santa Cruz Island, Daphne Major / Cruising, North Seymour Island, Puerto Baquerizo Moreno, San Cristobal Island, Punta Pitt, San Cristobal Island, Puerto Ayora, Santa Cruz Island, Baltra Island (Galapagos), Baltra / Quito Disembarkation, Quito, Ecuador
2026 Sails: Jan 16, Jan 30, Feb 13, Feb 27, Apr 10, Jun 5, Jun 19, Jul 3, Jul 17, Jul 31, Aug 14, Aug 28, Sep 11, Sep 25, Oct 9, Oct 23, Nov 6, Nov 20, Dec 4, Dec 18, 2027: Jan 1, Jan 15, Jan 29, Feb 12, More...16 Night - Galapagos Inner Loop & Machu Picchu
Starting in Quito, Ecuador, Quito to Baltra Embarkation, Baltra Island (Galapagos), Egas Port, Santiago Island, Rabida Island, Elizabeth Bay, Tagus Cove, Isabela Island, Sullivan Bay (Santiago Island), Bartolome Island, Las Bachas, Santa Cruz Island, Daphne Major / Cruising, North Seymour Island, Puerto Baquerizo Moreno, San Cristobal Island, Punta Pitt, San Cristobal Island, Puerto Ayora, Santa Cruz Island, Baltra Island (Galapagos), Baltra / Quito Disembarkation Fly to Quito, Lima, Peru, Fly from Lima to Cuzco and the Sacred Valley, Peru, The Sacred Valley, Sacred Valley and Machu Picchu, Cuzco, Peru, Fly to Lima, Peru / Depart Lima, Peru, Depart Lima, Peru
2026 Sails: Jan 16, Jan 30, Feb 13, Feb 27, Apr 10, Jun 5, Jun 19, Jul 3, Jul 17, Jul 31, Aug 14, Aug 28, Sep 11, Sep 25, Oct 9, Oct 23, Nov 6, Nov 20, Dec 4, Dec 18, 2027: Jan 1, Jan 15, Jan 29, Feb 12, More...16 Night - Galapagos Outer Loop & Machu Picchu
Starting in Quito, Ecuador, Quito to Baltra Embarkation, Baltra Island (Galapagos), Gardner Bay (Espanola), Punta Suarez, Cormorant Point (Floreana), Post Office Bay, Floreana Island, Moreno Point, Isabela Island, Urbina Bay, Espinoza Point, Vicente Roca Point, South Plaza (Santa Cruz Island), Daphne Major / Cruising, Dragon Hill (Santa Cruz Island), Puerto Ayora, Santa Cruz Island, Baltra Island (Galapagos), Baltra / Quito Disembarkation Fly to Quito, Lima, Peru, Fly from Lima to Cuzco and the Sacred Valley, Peru, The Sacred Valley, Sacred Valley and Machu Picchu, Cuzco, Peru, Fly to Lima, Peru / Depart Lima, Peru, Depart Lima, Peru
2026 Sails: Feb 6, Feb 20, Mar 6, Apr 3, May 1, May 29, Jun 12, Jun 26, Jul 10, Jul 24, Aug 7, Aug 21, Sep 4, Sep 18, Oct 2, Oct 16, Oct 30, Nov 13, Nov 27, Dec 11, Dec 25, 2027: Jan 8, Jan 22, Feb 5, More...11 Night - Quito & Galapagos Outer Loop
Starting in Quito, Ecuador, Quito to Baltra Embarkation, Baltra Island (Galapagos), Gardner Bay (Espanola), Punta Suarez, Cormorant Point (Floreana), Post Office Bay, Floreana Island, Moreno Point, Isabela Island, Urbina Bay, Espinoza Point, Vicente Roca Point, South Plaza (Santa Cruz Island), Daphne Major / Cruising, Dragon Hill (Santa Cruz Island), Puerto Ayora, Santa Cruz Island, Baltra Island (Galapagos), Baltra / Quito Disembarkation, Quito, Ecuador
2026 Sails: Feb 6, Feb 20, Mar 6, Apr 3, May 1, May 29, Jun 12, Jun 26, Jul 10, Jul 24, Aug 7, Aug 21, Sep 4, Sep 18, Oct 2, Oct 16, Oct 30, Nov 13, Nov 27, Dec 11, Dec 25, 2027: Jan 8, Jan 22, Feb 5, More...10 Night - Quito & Galapagos Outer Loop
Starting in Quito, Ecuador, Quito to Baltra Embarkation, Baltra Island (Galapagos), Gardner Bay (Espanola), Punta Suarez, Cormorant Point (Floreana), Post Office Bay, Floreana Island, Moreno Point, Isabela Island, Urbina Bay, Espinoza Point, Vicente Roca Point, South Plaza (Santa Cruz Island), Daphne Major / Cruising, Dragon Hill (Santa Cruz Island), Puerto Ayora, Santa Cruz Island, Baltra Island (Galapagos), Baltra / Quito Disembarkation, Quito, Ecuador
2026 Sails: Feb 6, Feb 20, Mar 6, Apr 3, May 1, May 29, Jun 12, Jun 26, Jul 10, Jul 24, Aug 7, Aug 21, Sep 4, Sep 18, Oct 2, Oct 16, Oct 30, Nov 13, Nov 27, Dec 11, Dec 25, 2027: Jan 8, Jan 22, Feb 5, More...
19 Night - From the Inca Empire to the Peruvian Amazon with the Nazca Lines & Galapagos Cruise
Starting in Arrive in Lima, Peru, Lima / Pisco / Paracas and Nazca Lines, Paracas / Ballestas Islands Cruise / Lima, Lima, Sacred Valley, Machu Picchu, Cusco, Cusco / Lima / Iquitos / Nauta (Embarkation), Peruvian Amazon, Iquitos (Disembarkation), Lima / Quito, Quito, Baltra, Galapagos Islands (Embarkation) Santa Cruz Island, Santa Cruz Island, Floreana Island, Espanola Island, Galapagos Islands (Disembarkation) San Cristobal / Quito, Quito
2026 Sails: May 8, May 22, Jun 5, Oct 9, Oct 23, Nov 6, More...17 Night - From the Inca Empire to the Peruvian Amazon with Galapagos Cruise
Starting in Lima, Peru, Lima, Sacred Valley, Machu Picchu, Cusco, Cusco / Lima / Iquitos / Nauta (Embarkation), Peruvian Amazon, Iquitos (Disembarkation), Lima / Quito, Quito, Baltra, Galapagos Islands (Embarkation) Santa Cruz Island, Santa Cruz Island, Floreana Island, Espanola Island, Galapagos Islands (Disembarkation) San Cristobal / Quito, Quito
2026 Sails: May 10, May 24, Jun 7, Oct 11, Oct 25, Nov 8, More...
Cruises that visit South America: Ecuador: Galapagos Islands: Santa Cruz Island
Cruises that depart from Santa Cruz Island
See all River Cruises that visit Santa Cruz Island
Click on a cruise ship itinerary that visits Santa Cruz Island (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Santa Cruz Island), please visit: Cruise Search or try our Virtual Cruise Advisor™.
7 Night - Galapagos Outer Loop CruiseStarting in Baltra (Galapagos), Gardner Bay (Espanola), Suarez Point, (Espanola), Cormorant Point (Floreana), Bahia Post Office (Floreana), Moreno Point (Isabela), Urbina Bay (Isabela), Espinoza Point, (Fernandina), Vicente Roca Point (Isabela), South Plaza (Santa Cruz Island), Daphne Island, Dragon Hill (Santa Cruz Island), Puerto Ayora, Santa Cruz Island, Baltra (Galapagos)
2026 Sails: Jan 11, Feb 8, Feb 22, Mar 8, May 3, May 31, Jun 14, Jun 28, Jul 12, Jul 26, Aug 9, Aug 23, Sep 6, Sep 20, Oct 4, Oct 18, Nov 1, Nov 15, Nov 29, Dec 13, Dec 27, 2027: Jan 10, Jan 24, Feb 7, More...
11 Night - Quito & Galapagos Inner LoopStarting in Quito, Ecuador, Quito to Baltra Embarkation, Baltra Island (Galapagos), Egas Port, Santiago Island, Rabida Island, Elizabeth Bay, Tagus Cove, Isabela Island, Sullivan Bay (Santiago Island), Bartolome Island, Las Bachas, Santa Cruz Island, Daphne Major / Cruising, North Seymour Island, Puerto Baquerizo Moreno, San Cristobal Island, Punta Pitt, San Cristobal Island, Puerto Ayora, Santa Cruz Island, Baltra Island (Galapagos), Baltra / Quito Disembarkation, Quito, Ecuador
2026 Sails: Jan 16, Jan 30, Feb 13, Feb 27, Apr 10, Jun 5, Jun 19, Jul 3, Jul 17, Jul 31, Aug 14, Aug 28, Sep 11, Sep 25, Oct 9, Oct 23, Nov 6, Nov 20, Dec 4, Dec 18, 2027: Jan 1, Jan 15, Jan 29, Feb 12, More...
10 Night - Quito & Galapagos Inner LoopStarting in Quito, Ecuador, Quito to Baltra Embarkation, Baltra Island (Galapagos), Egas Port, Santiago Island, Rabida Island, Elizabeth Bay, Tagus Cove, Isabela Island, Sullivan Bay (Santiago Island), Bartolome Island, Las Bachas, Santa Cruz Island, Daphne Major / Cruising, North Seymour Island, Puerto Baquerizo Moreno, San Cristobal Island, Punta Pitt, San Cristobal Island, Puerto Ayora, Santa Cruz Island, Baltra Island (Galapagos), Baltra / Quito Disembarkation, Quito, Ecuador
2026 Sails: Jan 16, Jan 30, Feb 13, Feb 27, Apr 10, Jun 5, Jun 19, Jul 3, Jul 17, Jul 31, Aug 14, Aug 28, Sep 11, Sep 25, Oct 9, Oct 23, Nov 6, Nov 20, Dec 4, Dec 18, 2027: Jan 1, Jan 15, Jan 29, Feb 12, More...
16 Night - Galapagos Inner Loop & Machu PicchuStarting in Quito, Ecuador, Quito to Baltra Embarkation, Baltra Island (Galapagos), Egas Port, Santiago Island, Rabida Island, Elizabeth Bay, Tagus Cove, Isabela Island, Sullivan Bay (Santiago Island), Bartolome Island, Las Bachas, Santa Cruz Island, Daphne Major / Cruising, North Seymour Island, Puerto Baquerizo Moreno, San Cristobal Island, Punta Pitt, San Cristobal Island, Puerto Ayora, Santa Cruz Island, Baltra Island (Galapagos), Baltra / Quito Disembarkation Fly to Quito, Lima, Peru, Fly from Lima to Cuzco and the Sacred Valley, Peru, The Sacred Valley, Sacred Valley and Machu Picchu, Cuzco, Peru, Fly to Lima, Peru / Depart Lima, Peru, Depart Lima, Peru
2026 Sails: Jan 16, Jan 30, Feb 13, Feb 27, Apr 10, Jun 5, Jun 19, Jul 3, Jul 17, Jul 31, Aug 14, Aug 28, Sep 11, Sep 25, Oct 9, Oct 23, Nov 6, Nov 20, Dec 4, Dec 18, 2027: Jan 1, Jan 15, Jan 29, Feb 12, More...
16 Night - Galapagos Outer Loop & Machu PicchuStarting in Quito, Ecuador, Quito to Baltra Embarkation, Baltra Island (Galapagos), Gardner Bay (Espanola), Punta Suarez, Cormorant Point (Floreana), Post Office Bay, Floreana Island, Moreno Point, Isabela Island, Urbina Bay, Espinoza Point, Vicente Roca Point, South Plaza (Santa Cruz Island), Daphne Major / Cruising, Dragon Hill (Santa Cruz Island), Puerto Ayora, Santa Cruz Island, Baltra Island (Galapagos), Baltra / Quito Disembarkation Fly to Quito, Lima, Peru, Fly from Lima to Cuzco and the Sacred Valley, Peru, The Sacred Valley, Sacred Valley and Machu Picchu, Cuzco, Peru, Fly to Lima, Peru / Depart Lima, Peru, Depart Lima, Peru
2026 Sails: Feb 6, Feb 20, Mar 6, Apr 3, May 1, May 29, Jun 12, Jun 26, Jul 10, Jul 24, Aug 7, Aug 21, Sep 4, Sep 18, Oct 2, Oct 16, Oct 30, Nov 13, Nov 27, Dec 11, Dec 25, 2027: Jan 8, Jan 22, Feb 5, More...
11 Night - Quito & Galapagos Outer LoopStarting in Quito, Ecuador, Quito to Baltra Embarkation, Baltra Island (Galapagos), Gardner Bay (Espanola), Punta Suarez, Cormorant Point (Floreana), Post Office Bay, Floreana Island, Moreno Point, Isabela Island, Urbina Bay, Espinoza Point, Vicente Roca Point, South Plaza (Santa Cruz Island), Daphne Major / Cruising, Dragon Hill (Santa Cruz Island), Puerto Ayora, Santa Cruz Island, Baltra Island (Galapagos), Baltra / Quito Disembarkation, Quito, Ecuador
2026 Sails: Feb 6, Feb 20, Mar 6, Apr 3, May 1, May 29, Jun 12, Jun 26, Jul 10, Jul 24, Aug 7, Aug 21, Sep 4, Sep 18, Oct 2, Oct 16, Oct 30, Nov 13, Nov 27, Dec 11, Dec 25, 2027: Jan 8, Jan 22, Feb 5, More...
10 Night - Quito & Galapagos Outer LoopStarting in Quito, Ecuador, Quito to Baltra Embarkation, Baltra Island (Galapagos), Gardner Bay (Espanola), Punta Suarez, Cormorant Point (Floreana), Post Office Bay, Floreana Island, Moreno Point, Isabela Island, Urbina Bay, Espinoza Point, Vicente Roca Point, South Plaza (Santa Cruz Island), Daphne Major / Cruising, Dragon Hill (Santa Cruz Island), Puerto Ayora, Santa Cruz Island, Baltra Island (Galapagos), Baltra / Quito Disembarkation, Quito, Ecuador
2026 Sails: Feb 6, Feb 20, Mar 6, Apr 3, May 1, May 29, Jun 12, Jun 26, Jul 10, Jul 24, Aug 7, Aug 21, Sep 4, Sep 18, Oct 2, Oct 16, Oct 30, Nov 13, Nov 27, Dec 11, Dec 25, 2027: Jan 8, Jan 22, Feb 5, More...
19 Night - From the Inca Empire to the Peruvian Amazon with the Nazca Lines & Galapagos CruiseStarting in Arrive in Lima, Peru, Lima / Pisco / Paracas and Nazca Lines, Paracas / Ballestas Islands Cruise / Lima, Lima, Sacred Valley, Machu Picchu, Cusco, Cusco / Lima / Iquitos / Nauta (Embarkation), Peruvian Amazon, Iquitos (Disembarkation), Lima / Quito, Quito, Baltra, Galapagos Islands (Embarkation) Santa Cruz Island, Santa Cruz Island, Floreana Island, Espanola Island, Galapagos Islands (Disembarkation) San Cristobal / Quito, Quito
2026 Sails: May 8, May 22, Jun 5, Oct 9, Oct 23, Nov 6, More...
17 Night - From the Inca Empire to the Peruvian Amazon with Galapagos CruiseStarting in Lima, Peru, Lima, Sacred Valley, Machu Picchu, Cusco, Cusco / Lima / Iquitos / Nauta (Embarkation), Peruvian Amazon, Iquitos (Disembarkation), Lima / Quito, Quito, Baltra, Galapagos Islands (Embarkation) Santa Cruz Island, Santa Cruz Island, Floreana Island, Espanola Island, Galapagos Islands (Disembarkation) San Cristobal / Quito, Quito
2026 Sails: May 10, May 24, Jun 7, Oct 11, Oct 25, Nov 8, More...
