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Santa Cruz Island Cruises

Cruises that visit South America: Ecuador: Galapagos Islands: Santa Cruz Island

Cruises that depart from Santa Cruz Island

See all River Cruises that visit Santa Cruz Island

Click on a cruise ship itinerary that visits Santa Cruz Island (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Santa Cruz Island), please visit: Cruise Search or try our Virtual Cruise Advisor™.


Avalon Waterways Cruise Tours, Delfin III Cruise Tours
Delfin III Cruises19 Night - From the Inca Empire to the Peruvian Amazon with the Nazca Lines & Galapagos Cruise
Starting in Arrive in Lima, Peru, Lima / Pisco / Paracas and Nazca Lines, Paracas / Ballestas Islands Cruise / Lima, Lima, Sacred Valley, Machu Picchu, Cusco, Cusco / Lima / Iquitos / Nauta (Embarkation), Peruvian Amazon, Iquitos (Disembarkation), Lima / Quito, Quito, Baltra, Galapagos Islands (Embarkation) Santa Cruz Island, Santa Cruz Island, Floreana Island, Espanola Island, Galapagos Islands (Disembarkation) San Cristobal / Quito, Quito
2026 Sails: Oct 9, Oct 23, Nov 6, More...
Avalon Waterways Cruise Tours, Delfin III Cruise Tours
Delfin III Cruises17 Night - From the Inca Empire to the Peruvian Amazon with Galapagos Cruise
Starting in Lima, Peru, Lima, Sacred Valley, Machu Picchu, Cusco, Cusco / Lima / Iquitos / Nauta (Embarkation), Peruvian Amazon, Iquitos (Disembarkation), Lima / Quito, Quito, Baltra, Galapagos Islands (Embarkation) Santa Cruz Island, Santa Cruz Island, Floreana Island, Espanola Island, Galapagos Islands (Disembarkation) San Cristobal / Quito, Quito
2026 Sails: Oct 11, Oct 25, Nov 8, More...

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Santa Cruz Island Cruises