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Santa Cruz Island Cruise Departures

Cruises that depart from South America: Ecuador: Galapagos Islands: Santa Cruz Island

Cruises that visit Santa Cruz Island

Click on a cruise ship itinerary sailing from Santa Cruz Island (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Santa Cruz Island), please visit: Cruise Search or try our Virtual Cruise Advisor™.


Isabela II Cruises4 Night - Western Galapagos Islands Roundtrip from Baltra Island
Starting in Santa Cruz Island, Puerto Ayora / Charles Darwin Research Station, Bartolome Island, Sullivan Bay (Santiago Island), Dragon Hill (Santa Cruz Island), Buccaneer Cove (Santiago Island), Punta Vicente Roca (Isabela Island), Punta Espinoza (Fernandina Island), Baltra Island
2025 Sails: Nov 20, Nov 21, Dec 4, Dec 18, More...
Isabela II Cruises4 Night - Northern Galapagos Islands Roundtrip from Baltra Island
Starting in Santa Cruz Island, Santa Cruz Islands Highlands / Puerto Ayora, Puerto Egas (Santiago Island), Chinese Hat Islet, Prince Philips Steps (Genovesa Island), Darwin Bay (Genovesa Island), Santa Fe Island, South Plaza Island, Baltra Island
2025 Sails: Nov 24, Dec 8, Dec 22, More...
Isabela II Cruises6 Night - Southeastern Galapagos Islands Roundtrip from Baltra Island
Starting in Santa Cruz Island, Las Bachas, Santa Cruz Island, Punta Pitt (San Cristobal), Cerro Colorado (San Cristobal Island), Gardner Bay (Espanola Island), Punta Suarez (Espanola Island), Cormorant Point (Floreana Island), Post Office Bay / Baroness Cove (Floreana Island), Punta Moreno (Isabela Island), Punta Mangle (Fernandina Island), Eden Islet, North Seymour Island, Baltra Island
2025 Sails: Nov 28, Dec 12, Dec 26, More...
La Pinta Cruises4 Night - Northern Galapagos Islands Roundtrip from Baltra Island
Starting in Santa Cruz Island / Baltra Island, Chinese Hat Islet, Bartolome Island / Santiago Island, Genovesa Island, Baltra Island
2025 Sails: Dec 1, Dec 15, More...
La Pinta Cruises4 Night - Northeastern Origin of Species Adventure Roundtrip from Santa Cruz & Baltra Islands
Starting in Santa Cruz Island / Baltra Island, Santa Cruz and Chinese Hat Islet, Bartolome and Santiago Islands, Genovesa Island, Baltra Island
2026 Sails: Jan 12, Jan 26, Feb 9, Feb 23, Mar 9, Mar 23, Apr 6, Apr 20, May 4, May 18, Jun 1, Jun 15, Jun 29, Jul 13, Jul 27, Aug 10, Aug 24, Sep 7, Sep 21, Oct 5, Oct 19, Nov 2, Nov 16, Nov 30, More...

Santa Cruz Island Cruise Departures