Panama Canal Cruises
Cruises that visit Central America: Panama: Panama Canal
7 Night - Costa Rica & Panama Canal
Starting in Puerto Caldera, Golfo Dulce (Puerto Jimenez), Quepos, Isla Partida, Balboa / Fuerte Amador, Panama Canal, Colon
2026 Sails: Feb 2, Mar 2, More...
16 Night - Panama Canal - Ocean to Ocean
Starting in Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit Historic Locks, Aruba, Fort Lauderdale, Florida
2026 Sails: Feb 9, Sep 20, Dec 28, 2027: Mar 2, Apr 3, More...
15 Night - Panama Canal-Panama City
Starting in San Diego, Ca, Cabo San Lucas, Mexico, Acapulco, Mexico, Puerto Quetzal, Guatemala, Puntarenas / Puerto Caldera, Costa Rica, Panama City, Panama, Transit Panama Canal / At Sea, Cartagena CO, Miami, Fl
2026 Sails: Feb 12, More...
27 Night - Historic Sea of Cortez & Panama Canal
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, Guaymas, Mexico, Topolobampo, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, Ensenada, Mexico, San Diego, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Fuerte Amador, Panama, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, Half Moon Cay, Bahamas, Miami, Florida
2026 Sails: Feb 15, More...7 Night - Costa Rica & Panama Canal
Starting in Puerto Caldera, Golfo Dulce (Puerto Jimenez), Quepos, Isla Partida, Balboa / Fuerte Amador, Panama Canal, Colon
2026 Sails: Feb 16, More...
13 Night - Cruise from Colon to Puntarenas
Starting in Colon, San Blas Islands, Transit Panama Canal, Pearl Islands, Puerto Jimenez, Playa Mantas / Punta Leona, Quepos, Marina Flamingo / Playa Flamingo, Playa Panama, Puntarenas
2026 Sails: Feb 17, More...
7 Night - Panama and Costa Rica by Sea : the Natural Wonders of Central America - with Smithsonian Journeys
Starting in Colon, San Blas Islands, Crossing the Panama Canal, Playa Muerto, Darien National Park, Fuerte Amador, Flamenco Island, Quepos, Puntarenas
2026 Sails: Feb 19, More...7 Night - Panama and Costa Rica by Sea : the Natural Wonders of Central America - with Smithsonian Journeys
Starting in Puntarenas, Quepos, Playa Muerto, Darien National Park, Fuerte Amador, Flamenco Island, Crossing the Panama Canal, San Blas Islands, Colon
2026 Sails: Feb 26, More...
51 Night - Hong Kong to Miami
Starting in Hong Kong, China, Manila, Philippines, Bali, Indonesia, Darwin, NT, Australia, Airlie Beach, Australia, Brisbane, Australia, Sydney AU, Australia, Port Vila, Vanuatu, Suva, Fiji, Cross International Date Line (Cruise-by), Honolulu, HI, Los Angeles, CA, Puerto Quetzal, Guatemala, Transit the Panama Canal, Panama (Full Transit), Willemstad AN, Curacao, Oranjestad, Aruba, Miami, FL
2026 Sails: Feb 27, More...62 Night - Hong Kong to Southampton
Starting in Hong Kong, China, Manila, Philippines, Bali, Indonesia, Darwin, NT, Australia, Airlie Beach, Australia, Brisbane, Australia, Sydney AU, Australia, Port Vila, Vanuatu, Suva, Fiji, Cross International Date Line (Cruise-by), Honolulu, HI, Los Angeles, CA, Puerto Quetzal, Guatemala, Transit the Panama Canal, Panama (Full Transit), Willemstad AN, Curacao, Oranjestad, Aruba, Miami, FL, Ponta Delgada, Azores, Portugal, Southampton, England, UK
2026 Sails: Feb 27, More...
Cruises that visit Central America: Panama: Panama Canal
Click on a cruise ship itinerary that visits Panama Canal (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama Canal), please visit: Cruise Search or try our Virtual Cruise Advisor™.
7 Night - Costa Rica & Panama CanalStarting in Puerto Caldera, Golfo Dulce (Puerto Jimenez), Quepos, Isla Partida, Balboa / Fuerte Amador, Panama Canal, Colon
2026 Sails: Feb 2, Mar 2, More...
16 Night - Panama Canal - Ocean to OceanStarting in Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit Historic Locks, Aruba, Fort Lauderdale, Florida
2026 Sails: Feb 9, Sep 20, Dec 28, 2027: Mar 2, Apr 3, More...
15 Night - Panama Canal-Panama CityStarting in San Diego, Ca, Cabo San Lucas, Mexico, Acapulco, Mexico, Puerto Quetzal, Guatemala, Puntarenas / Puerto Caldera, Costa Rica, Panama City, Panama, Transit Panama Canal / At Sea, Cartagena CO, Miami, Fl
2026 Sails: Feb 12, More...
27 Night - Historic Sea of Cortez & Panama CanalStarting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, Guaymas, Mexico, Topolobampo, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, Ensenada, Mexico, San Diego, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Fuerte Amador, Panama, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, Half Moon Cay, Bahamas, Miami, Florida
2026 Sails: Feb 15, More...
Deal link -> Special
7 Night - Costa Rica & Panama CanalStarting in Puerto Caldera, Golfo Dulce (Puerto Jimenez), Quepos, Isla Partida, Balboa / Fuerte Amador, Panama Canal, Colon
2026 Sails: Feb 16, More...
13 Night - Cruise from Colon to PuntarenasStarting in Colon, San Blas Islands, Transit Panama Canal, Pearl Islands, Puerto Jimenez, Playa Mantas / Punta Leona, Quepos, Marina Flamingo / Playa Flamingo, Playa Panama, Puntarenas
2026 Sails: Feb 17, More...
7 Night - Panama and Costa Rica by Sea : the Natural Wonders of Central America - with Smithsonian JourneysStarting in Colon, San Blas Islands, Crossing the Panama Canal, Playa Muerto, Darien National Park, Fuerte Amador, Flamenco Island, Quepos, Puntarenas
2026 Sails: Feb 19, More...
7 Night - Panama and Costa Rica by Sea : the Natural Wonders of Central America - with Smithsonian JourneysStarting in Puntarenas, Quepos, Playa Muerto, Darien National Park, Fuerte Amador, Flamenco Island, Crossing the Panama Canal, San Blas Islands, Colon
2026 Sails: Feb 26, More...
51 Night - Hong Kong to MiamiStarting in Hong Kong, China, Manila, Philippines, Bali, Indonesia, Darwin, NT, Australia, Airlie Beach, Australia, Brisbane, Australia, Sydney AU, Australia, Port Vila, Vanuatu, Suva, Fiji, Cross International Date Line (Cruise-by), Honolulu, HI, Los Angeles, CA, Puerto Quetzal, Guatemala, Transit the Panama Canal, Panama (Full Transit), Willemstad AN, Curacao, Oranjestad, Aruba, Miami, FL
2026 Sails: Feb 27, More...
62 Night - Hong Kong to SouthamptonStarting in Hong Kong, China, Manila, Philippines, Bali, Indonesia, Darwin, NT, Australia, Airlie Beach, Australia, Brisbane, Australia, Sydney AU, Australia, Port Vila, Vanuatu, Suva, Fiji, Cross International Date Line (Cruise-by), Honolulu, HI, Los Angeles, CA, Puerto Quetzal, Guatemala, Transit the Panama Canal, Panama (Full Transit), Willemstad AN, Curacao, Oranjestad, Aruba, Miami, FL, Ponta Delgada, Azores, Portugal, Southampton, England, UK
2026 Sails: Feb 27, More...
