Panama Canal Cruises
Cruises that visit Central America: Panama: Panama Canal
16 Night - Panama Canal - Ocean to Ocean
Starting in Fort Lauderdale, Florida, Cartagena CO, Panama Canal Full Transit Historic Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2026 Sails: Jan 24, More...
16 Night - Stars & Salsa
Starting in Los Angeles, Cruising the Pacific Ocean, Cabo San Lucas, Cruising the Pacific Ocean, Acapulco, Cruising the Pacific Ocean, Puerto Quetzal, Cruising the Pacific Ocean, Puntarenas, Cruising the Pacific Ocean, Panama Canal Transit, Cartagena CO, Cruising the Caribbean Sea, George Town, Cruising the Florida Straits, Miami
2026 Sails: Jan 25, More...
10 Night - Canal & Caribbean Discovery
Starting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Kralendijk, Willemstad AN, Oranjestad, Port Antonio, Miami
2026 Sails: Jan 27, More...
76 Night - Central America Roundtrip from Southampton
Starting in Southampton, La Coruna, Las Palmas, Praia, Salvador, Rio De Janeiro, Ilhabela, Brazil, Buenos Aires, Montevideo, Port Stanley, Falkland Islands, Cruising by Antarctic Peninsula, Punta Arenas, Cruising Chilean Fjords, Valparaiso, Coquimbo, Iquique, Arica, Paracas, Callao, Amador, Panama Canal Transit, Puerto Limon, Colon, Cartagena De Indias, Colombia, Willemstad AN, Bequia, St Johns, Philipsburg, Ponta Delgada, Southampton
2026 Sails: Jan 28, More...
21 Night - Southern Caribbean & Panama Canal : Abc Islands
Starting in Fort Lauderdale, Florida, Willemstad AN, Curacao, Kralendijk, Bonaire, Oranjestad, Aruba, Half Moon Cay, Bahamas, Fort Lauderdale, Florida, Half Moon Cay, Bahamas, Willemstad AN, Curacao, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal and Gatun Lake, Gatun Lake, Panama, Cruising Gatun Lake and Panama Canal, Exit Panama Canal Cristobal, Colon, Panama, Puerto Limon (San Jose), Costa Rica, Georgetown, Cayman Islands, Fort Lauderdale, Florida
2026 Sails: Jan 30, Feb 20, More...
27 Night - Panama Canal & Historic Sea of Cortez
Starting in Miami, Florida, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Puntarenas (Puerto Caldera), Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Huatulco, Mexico, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, Guaymas, Mexico, Topolobampo, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, Ensenada, Mexico, San Diego, California
2026 Sails: Jan 31, More...15 Night - Panama Canal with History Channel
Starting in Miami, Florida, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Puntarenas (Puerto Caldera), Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Huatulco, Mexico, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, California
2026 Sails: Jan 31, More...
13 Night - Journeys - Caribbean & Panama
Starting in Tampa, Fl, Grand Cayman, Cayman Islands, Limon, Costa Rica, Colon (Panama Canal), Panama, Aruba, Curacao, Amber Cove, Dominican Republic, Tampa, Fl
2026 Sails: Feb 1, More...
14 Night - Journeys - Caribbean & Panama
Starting in Galveston, Tx, Montego Bay, Jamaica, Aruba, Curacao, Cartagena CO, Colon (Panama Canal), Panama, Limon, Costa Rica, Cozumel, Mexico, Galveston, Tx
2026 Sails: Feb 2, More...
11 Night - Panama Canal & Southern Caribbean
Starting in Fort Lauderdale, Florida, Cartagena CO, Panama Canal (Cruising), Colon, Panama, Oranjestad, Aruba, Willemstad AN, Curacao, George Town, Grand Cayman, Fort Lauderdale, Florida
2026 Sails: Feb 2, More...
Cruises that visit Central America: Panama: Panama Canal
Click on a cruise ship itinerary that visits Panama Canal (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama Canal), please visit: Cruise Search or try our Virtual Cruise Advisor™.
16 Night - Panama Canal - Ocean to OceanStarting in Fort Lauderdale, Florida, Cartagena CO, Panama Canal Full Transit Historic Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2026 Sails: Jan 24, More...
16 Night - Stars & SalsaStarting in Los Angeles, Cruising the Pacific Ocean, Cabo San Lucas, Cruising the Pacific Ocean, Acapulco, Cruising the Pacific Ocean, Puerto Quetzal, Cruising the Pacific Ocean, Puntarenas, Cruising the Pacific Ocean, Panama Canal Transit, Cartagena CO, Cruising the Caribbean Sea, George Town, Cruising the Florida Straits, Miami
2026 Sails: Jan 25, More...
10 Night - Canal & Caribbean DiscoveryStarting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Kralendijk, Willemstad AN, Oranjestad, Port Antonio, Miami
2026 Sails: Jan 27, More...
76 Night - Central America Roundtrip from SouthamptonStarting in Southampton, La Coruna, Las Palmas, Praia, Salvador, Rio De Janeiro, Ilhabela, Brazil, Buenos Aires, Montevideo, Port Stanley, Falkland Islands, Cruising by Antarctic Peninsula, Punta Arenas, Cruising Chilean Fjords, Valparaiso, Coquimbo, Iquique, Arica, Paracas, Callao, Amador, Panama Canal Transit, Puerto Limon, Colon, Cartagena De Indias, Colombia, Willemstad AN, Bequia, St Johns, Philipsburg, Ponta Delgada, Southampton
2026 Sails: Jan 28, More...
21 Night - Southern Caribbean & Panama Canal : Abc IslandsStarting in Fort Lauderdale, Florida, Willemstad AN, Curacao, Kralendijk, Bonaire, Oranjestad, Aruba, Half Moon Cay, Bahamas, Fort Lauderdale, Florida, Half Moon Cay, Bahamas, Willemstad AN, Curacao, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal and Gatun Lake, Gatun Lake, Panama, Cruising Gatun Lake and Panama Canal, Exit Panama Canal Cristobal, Colon, Panama, Puerto Limon (San Jose), Costa Rica, Georgetown, Cayman Islands, Fort Lauderdale, Florida
2026 Sails: Jan 30, Feb 20, More...
27 Night - Panama Canal & Historic Sea of CortezStarting in Miami, Florida, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Puntarenas (Puerto Caldera), Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Huatulco, Mexico, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, Guaymas, Mexico, Topolobampo, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, Ensenada, Mexico, San Diego, California
2026 Sails: Jan 31, More...
15 Night - Panama Canal with History ChannelStarting in Miami, Florida, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Puntarenas (Puerto Caldera), Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Huatulco, Mexico, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, California
2026 Sails: Jan 31, More...
13 Night - Journeys - Caribbean & PanamaStarting in Tampa, Fl, Grand Cayman, Cayman Islands, Limon, Costa Rica, Colon (Panama Canal), Panama, Aruba, Curacao, Amber Cove, Dominican Republic, Tampa, Fl
2026 Sails: Feb 1, More...
14 Night - Journeys - Caribbean & PanamaStarting in Galveston, Tx, Montego Bay, Jamaica, Aruba, Curacao, Cartagena CO, Colon (Panama Canal), Panama, Limon, Costa Rica, Cozumel, Mexico, Galveston, Tx
2026 Sails: Feb 2, More...
Deal link -> Special
11 Night - Panama Canal & Southern CaribbeanStarting in Fort Lauderdale, Florida, Cartagena CO, Panama Canal (Cruising), Colon, Panama, Oranjestad, Aruba, Willemstad AN, Curacao, George Town, Grand Cayman, Fort Lauderdale, Florida
2026 Sails: Feb 2, More...
