Panama Canal Cruises
Cruises that visit Central America: Panama: Panama Canal
109 Night - Full World Voyage
Starting in Southampton, England, UK, Funchal, Madeira, Portugal, Tenerife, Spain, Mindelo, St Vincent, Cape Verde, Walvis Bay, Namibia, Cape Town, South Africa, Gqeberha (Port Elizabeth ZA), South Africa, Durban, South Africa, Le Port, Reunion, Port Louis, Mauritius, Colombo, Sri Lanka, Port Kelang (tours to Kuala Lumpur), Malaysia, Singapore, Hong Kong, China, Manila, Philippines, Bali, Indonesia, Darwin, NT, Australia, Airlie Beach, Australia, Brisbane, Australia, Sydney AU, Australia, Port Vila, Vanuatu, Suva, Fiji, Cross International Date Line (Cruise-by), Honolulu, HI, Los Angeles, CA, Puerto Quetzal, Guatemala, Transit the Panama Canal, Panama (Full Transit), Willemstad AN, Curacao, Oranjestad, Aruba, Miami, FL, Ponta Delgada, Azores, Portugal, Southampton, England, UK
2026 Sails: Jan 11, More...
52 Night - Southampton to Sydney
Starting in Southampton, England, UK, New York, NY, Cartagena CO, Transit the Panama Canal, Panama (Full Transit), Fuerte Amador (tours to Panama City), Panama, Manzanillo, Mexico, Los Angeles, CA, San Francisco, CA, Honolulu, HI, Kona, HI, Papeete, French Polynesia, Moorea, French Polynesia, Cross International Date Line (Cruise-by), Bay of Islands, New Zealand, Auckland, New Zealand, Tauranga, New Zealand, Sydney AU, Australia
2026 Sails: Jan 11, More...26 Night - Southampton to San Francisco
Starting in Southampton, England, UK, New York, NY, Cartagena CO, Transit the Panama Canal, Panama (Full Transit), Fuerte Amador (tours to Panama City), Panama, Manzanillo, Mexico, Los Angeles, CA, San Francisco, CA
2026 Sails: Jan 11, More...109 Night - Full World Voyage
Starting in Southampton, England, UK, New York, NY, Cartagena CO, Transit the Panama Canal, Panama (Full Transit), Fuerte Amador (tours to Panama City), Panama, Manzanillo, Mexico, Los Angeles, CA, San Francisco, CA, Honolulu, HI, Kona, HI, Papeete, French Polynesia, Moorea, French Polynesia, Cross International Date Line (Cruise-by), Bay of Islands, New Zealand, Auckland, New Zealand, Tauranga, New Zealand, Sydney AU, Australia, Brisbane, Australia, Yorkeys Knob (tours to Cairns), Australia, Darwin, NT, Australia, Bitung, Indonesia, Hong Kong, China, Chan May (tours to Hue or Da Nang), Vietnam, Singapore, Port Kelang (tours to Kuala Lumpur), Malaysia, Port Louis, Mauritius, Durban, South Africa, Cape Town, South Africa, Walvis Bay, Namibia, Dakar, Senegal, Tenerife, Spain, Cadiz (tours to Seville), Spain, Southampton, England, UK
2026 Sails: Jan 11, More...
35 Night - Tropical Escapades, East to West
Starting in Miami, Cruising the Florida Straits, Cruising the Caribbean Sea, Cartagena CO, Panama Canal Transit, Cruising the Pacific Ocean, Puntarenas, Cruising the Pacific Ocean, Puerto Quetzal, Cruising the Pacific Ocean, Acapulco, Cruising the Pacific Ocean, Cabo San Lucas, Cruising the Pacific Ocean, Hilo, Kahului, Honolulu, Nawiliwili, Kailua-Kona, Hilo, Cruising the Pacific Ocean, Cruising the South Pacific, Rangiroa, Raiatea, Bora Bora, Papeete (Tahiti)
2026 Sails: Jan 11, More...21 Night - Crossing Horizons
Starting in Miami, Cruising the Florida Straits, Cruising the Caribbean Sea, Cartagena CO, Panama Canal Transit, Cruising the Pacific Ocean, Puntarenas, Cruising the Pacific Ocean, Puerto Quetzal, Cruising the Pacific Ocean, Acapulco, Cruising the Pacific Ocean, Cabo San Lucas, Cruising the Pacific Ocean, Hilo, Kahului, Honolulu
2026 Sails: Jan 11, More...
6 Night - Panama Canal, Cartagena, San Blas Islands & More
Starting in Balboa, Panama City, Panama Canal, Bocas del Toro, San Blas, Panama, Cartagena CO, Oranjestad
2026 Sails: Jan 11, More...
11 Night - Panama Canal - Miami
Starting in Miami, Fl, Ocho Rios, Jamaica, Cartagena CO, Panama Canal Gatun Lake, Panama, Colon, Panama, Puerto Limon, Costa Rica, Costa Maya, Mexico, Great Stirrup Cay, Bahamas, Miami, Fl
2026 Sails: Jan 13, More...
8 Night - Caribbean & Panama
Starting in Tampa, Fl, Limon, Costa Rica, Colon (Panama Canal), Panama, Grand Cayman, Cayman Islands, Tampa, Fl
2026 Sails: Jan 17, Mar 14, More...
20 Night - Caribbean Kaleidoscope
Starting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Harvest Caye, Santo Tomas, Roatan, Puerto Limon, Panama Canal Daylight Transit, Panama City, Panama Canal Daylight Transit, Cartagena CO, Kralendijk, Willemstad AN, Oranjestad, Port Antonio, Miami
2026 Sails: Jan 17, More...
Cruises that visit Central America: Panama: Panama Canal
Click on a cruise ship itinerary that visits Panama Canal (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama Canal), please visit: Cruise Search or try our Virtual Cruise Advisor™.
109 Night - Full World VoyageStarting in Southampton, England, UK, Funchal, Madeira, Portugal, Tenerife, Spain, Mindelo, St Vincent, Cape Verde, Walvis Bay, Namibia, Cape Town, South Africa, Gqeberha (Port Elizabeth ZA), South Africa, Durban, South Africa, Le Port, Reunion, Port Louis, Mauritius, Colombo, Sri Lanka, Port Kelang (tours to Kuala Lumpur), Malaysia, Singapore, Hong Kong, China, Manila, Philippines, Bali, Indonesia, Darwin, NT, Australia, Airlie Beach, Australia, Brisbane, Australia, Sydney AU, Australia, Port Vila, Vanuatu, Suva, Fiji, Cross International Date Line (Cruise-by), Honolulu, HI, Los Angeles, CA, Puerto Quetzal, Guatemala, Transit the Panama Canal, Panama (Full Transit), Willemstad AN, Curacao, Oranjestad, Aruba, Miami, FL, Ponta Delgada, Azores, Portugal, Southampton, England, UK
2026 Sails: Jan 11, More...
52 Night - Southampton to SydneyStarting in Southampton, England, UK, New York, NY, Cartagena CO, Transit the Panama Canal, Panama (Full Transit), Fuerte Amador (tours to Panama City), Panama, Manzanillo, Mexico, Los Angeles, CA, San Francisco, CA, Honolulu, HI, Kona, HI, Papeete, French Polynesia, Moorea, French Polynesia, Cross International Date Line (Cruise-by), Bay of Islands, New Zealand, Auckland, New Zealand, Tauranga, New Zealand, Sydney AU, Australia
2026 Sails: Jan 11, More...
26 Night - Southampton to San FranciscoStarting in Southampton, England, UK, New York, NY, Cartagena CO, Transit the Panama Canal, Panama (Full Transit), Fuerte Amador (tours to Panama City), Panama, Manzanillo, Mexico, Los Angeles, CA, San Francisco, CA
2026 Sails: Jan 11, More...
109 Night - Full World VoyageStarting in Southampton, England, UK, New York, NY, Cartagena CO, Transit the Panama Canal, Panama (Full Transit), Fuerte Amador (tours to Panama City), Panama, Manzanillo, Mexico, Los Angeles, CA, San Francisco, CA, Honolulu, HI, Kona, HI, Papeete, French Polynesia, Moorea, French Polynesia, Cross International Date Line (Cruise-by), Bay of Islands, New Zealand, Auckland, New Zealand, Tauranga, New Zealand, Sydney AU, Australia, Brisbane, Australia, Yorkeys Knob (tours to Cairns), Australia, Darwin, NT, Australia, Bitung, Indonesia, Hong Kong, China, Chan May (tours to Hue or Da Nang), Vietnam, Singapore, Port Kelang (tours to Kuala Lumpur), Malaysia, Port Louis, Mauritius, Durban, South Africa, Cape Town, South Africa, Walvis Bay, Namibia, Dakar, Senegal, Tenerife, Spain, Cadiz (tours to Seville), Spain, Southampton, England, UK
2026 Sails: Jan 11, More...
35 Night - Tropical Escapades, East to WestStarting in Miami, Cruising the Florida Straits, Cruising the Caribbean Sea, Cartagena CO, Panama Canal Transit, Cruising the Pacific Ocean, Puntarenas, Cruising the Pacific Ocean, Puerto Quetzal, Cruising the Pacific Ocean, Acapulco, Cruising the Pacific Ocean, Cabo San Lucas, Cruising the Pacific Ocean, Hilo, Kahului, Honolulu, Nawiliwili, Kailua-Kona, Hilo, Cruising the Pacific Ocean, Cruising the South Pacific, Rangiroa, Raiatea, Bora Bora, Papeete (Tahiti)
2026 Sails: Jan 11, More...
21 Night - Crossing HorizonsStarting in Miami, Cruising the Florida Straits, Cruising the Caribbean Sea, Cartagena CO, Panama Canal Transit, Cruising the Pacific Ocean, Puntarenas, Cruising the Pacific Ocean, Puerto Quetzal, Cruising the Pacific Ocean, Acapulco, Cruising the Pacific Ocean, Cabo San Lucas, Cruising the Pacific Ocean, Hilo, Kahului, Honolulu
2026 Sails: Jan 11, More...
6 Night - Panama Canal, Cartagena, San Blas Islands & MoreStarting in Balboa, Panama City, Panama Canal, Bocas del Toro, San Blas, Panama, Cartagena CO, Oranjestad
2026 Sails: Jan 11, More...
11 Night - Panama Canal - MiamiStarting in Miami, Fl, Ocho Rios, Jamaica, Cartagena CO, Panama Canal Gatun Lake, Panama, Colon, Panama, Puerto Limon, Costa Rica, Costa Maya, Mexico, Great Stirrup Cay, Bahamas, Miami, Fl
2026 Sails: Jan 13, More...
8 Night - Caribbean & PanamaStarting in Tampa, Fl, Limon, Costa Rica, Colon (Panama Canal), Panama, Grand Cayman, Cayman Islands, Tampa, Fl
2026 Sails: Jan 17, Mar 14, More...
20 Night - Caribbean KaleidoscopeStarting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Harvest Caye, Santo Tomas, Roatan, Puerto Limon, Panama Canal Daylight Transit, Panama City, Panama Canal Daylight Transit, Cartagena CO, Kralendijk, Willemstad AN, Oranjestad, Port Antonio, Miami
2026 Sails: Jan 17, More...
