Panama Canal Cruises
Cruises that visit Central America: Panama: Panama Canal
16 Night - Panama Canal
Starting in San Diego, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Acajutla, El Salvador, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, RelaxAway, Half Moon Cay, Bahamas, Fort Lauderdale, Florida
2026 Sails: Oct 2, More...
15 Night - Msc Grand Voyages
Starting in Los Angeles, San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Cruising Panama Canal, Colon, Panama, Cartagena CO, Miami, Florida
2026 Sails: Oct 2, More...
21 Night - Panama Canal
Starting in Seattle, Washington, Vancouver, BC, CA, Santa Barbara, California, San Diego, California, Cabo San Lucas, Mexico, Acapulco, Guerrero, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Puntarenas (Puerto Caldera), Costa Rica, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Oranjestad, Aruba, Fort Lauderdale, Florida
2026 Sails: Oct 3, More...14 Night - Msc Grand Voyages
Starting in San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Cruising Panama Canal, Colon, Panama, Cartagena CO, Colombia, Miami, Florida
2026 Sails: Oct 3, More...20 Night - Panama Canal
Starting in Vancouver, BC, CA, Santa Barbara, California, San Diego, California, Cabo San Lucas, Mexico, Acapulco, Guerrero, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Puntarenas (Puerto Caldera), Costa Rica, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Oranjestad, Aruba, Fort Lauderdale, Florida
2026 Sails: Oct 4, More...
16 Night - Panama Canal - Ocean to Ocean
Starting in Los Angeles, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit New Locks, Aruba, Fort Lauderdale, Florida
2026 Sails: Oct 4, More...
21 Night - Ultimate America's Historic Journey to Panama
Starting in New York, Wilmington, Delaware / Chesapeake and Delaware Canal, Baltimore, Maryland, Yorktown, Virginia, Wilmington, North Carolina, Charleston, South Carolina, Miami, Florida, Key West, Florida, Nassau, Bahamas, Staniel Cay, Bahamas, San Salvador Island, Bahamas, Cabo de La Vela, Colombia, Cartagena CO, San Blas, Panama, Bocas Del Toro, Panama, Panama Canal Transit / Panama City, Panama, Panama City, Panama
2026 Sails: Oct 5, More...
16 Night - Repo - Panama Canal
Starting in Los Angeles, Ca, Cabo San Lucas, Mexico, Acapulco, Mexico, Puerto Quetzal, Guatemala, Puerto Caldera / Puntarenas, Costa Rica, Panama City, Panama, Transit Panama Canal / At Sea, Cartagena CO, Ocho Rios, Jamaica, Miami, Fl
2026 Sails: Oct 7, More...
16 Night - Journeys - Panama Canal
Starting in Seattle, Wa, Cabo San Lucas, Mexico, Puntarenas, Costa Rica, Panama Canal Transit, Cartagena CO, Mobile, Al
2026 Sails: Oct 8, More...16 Night - Panama Canal
Starting in San Diego, California, Cabo San Lucas, Mexico, Acapulco, Guerrero, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Puntarenas (Puerto Caldera), Costa Rica, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Oranjestad, Aruba, Fort Lauderdale, Florida
2026 Sails: Oct 8, More...
Cruises that visit Central America: Panama: Panama Canal
Click on a cruise ship itinerary that visits Panama Canal (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama Canal), please visit: Cruise Search or try our Virtual Cruise Advisor™.
16 Night - Panama CanalStarting in San Diego, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Acajutla, El Salvador, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, RelaxAway, Half Moon Cay, Bahamas, Fort Lauderdale, Florida
2026 Sails: Oct 2, More...
15 Night - Msc Grand VoyagesStarting in Los Angeles, San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Cruising Panama Canal, Colon, Panama, Cartagena CO, Miami, Florida
2026 Sails: Oct 2, More...
Deal link -> Special
21 Night - Panama CanalStarting in Seattle, Washington, Vancouver, BC, CA, Santa Barbara, California, San Diego, California, Cabo San Lucas, Mexico, Acapulco, Guerrero, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Puntarenas (Puerto Caldera), Costa Rica, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Oranjestad, Aruba, Fort Lauderdale, Florida
2026 Sails: Oct 3, More...
14 Night - Msc Grand VoyagesStarting in San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Cruising Panama Canal, Colon, Panama, Cartagena CO, Colombia, Miami, Florida
2026 Sails: Oct 3, More...
20 Night - Panama CanalStarting in Vancouver, BC, CA, Santa Barbara, California, San Diego, California, Cabo San Lucas, Mexico, Acapulco, Guerrero, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Puntarenas (Puerto Caldera), Costa Rica, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Oranjestad, Aruba, Fort Lauderdale, Florida
2026 Sails: Oct 4, More...
16 Night - Panama Canal - Ocean to OceanStarting in Los Angeles, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit New Locks, Aruba, Fort Lauderdale, Florida
2026 Sails: Oct 4, More...
21 Night - Ultimate America's Historic Journey to PanamaStarting in New York, Wilmington, Delaware / Chesapeake and Delaware Canal, Baltimore, Maryland, Yorktown, Virginia, Wilmington, North Carolina, Charleston, South Carolina, Miami, Florida, Key West, Florida, Nassau, Bahamas, Staniel Cay, Bahamas, San Salvador Island, Bahamas, Cabo de La Vela, Colombia, Cartagena CO, San Blas, Panama, Bocas Del Toro, Panama, Panama Canal Transit / Panama City, Panama, Panama City, Panama
2026 Sails: Oct 5, More...
16 Night - Repo - Panama CanalStarting in Los Angeles, Ca, Cabo San Lucas, Mexico, Acapulco, Mexico, Puerto Quetzal, Guatemala, Puerto Caldera / Puntarenas, Costa Rica, Panama City, Panama, Transit Panama Canal / At Sea, Cartagena CO, Ocho Rios, Jamaica, Miami, Fl
2026 Sails: Oct 7, More...
16 Night - Journeys - Panama CanalStarting in Seattle, Wa, Cabo San Lucas, Mexico, Puntarenas, Costa Rica, Panama Canal Transit, Cartagena CO, Mobile, Al
2026 Sails: Oct 8, More...
16 Night - Panama CanalStarting in San Diego, California, Cabo San Lucas, Mexico, Acapulco, Guerrero, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Puntarenas (Puerto Caldera), Costa Rica, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Oranjestad, Aruba, Fort Lauderdale, Florida
2026 Sails: Oct 8, More...
