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South America Cruises

Cruises that visit South America

Cruises by region

See all South America River Cruises

Click on a cruise ship itinerary in South America (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just South America), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : South Georgia / South Sandwich Islands : Uruguay



AmaWaterways Tours, AmaMagdalena Tours
AmaMagdalena Tours10 Night - Magic of Colombia with Panama Post Cruise
Starting in Barranquilla, Sitionuevo, Magangue, Mompox, Santa Barbara de Pinto, Calamar, Mahates, Cartagena CO, Colombia, Panama City
2026 Sails: Nov 28, Dec 12, Dec 26, More...
Costa Cruise Lines, Costa Diadema
Costa Diadema4 Night - South America Roundtrip from Itajai
Starting in Itajai, Brazil, Santos / Sao Paulo, Ilhabela, Brazil, Camboriu, Brazil, Itajai, Brazil
2026 Sails: Nov 28, More...
HX Expeditions Tours, MS Roald Amundsen Tours
MS Roald Amundsen Tours15 Night - Antarctica & Falkland Expedition
Starting in Buenos Aires, Buenos Aires / Ezeiza Airport (International), Ushuaia Airport, Ushuaia, South Shetland, Northern Gerlache, Southern Gerlache, South Shetland, West Point Island, Saunders Island, Port Stanley, Ushuaia, Ushuaia Airport
2026 Sails: Nov 28, More...
HX Expeditions Tours, MS Santa Cruz II Tours
MS Santa Cruz II Tours6 Night - Nature and Wildlife Expedition Cruise (Northern Route)
Starting in Quito Airport, Quito, Quito Airport, Seymour, Las Bachas, Santa Cruz Island, Buccaneer Cove, Puerto Egas, Rabida Island, Bartolome Island, Prince Philip Steps, Genovesa Island, Darwin Bay, Genovesa Island, Itabaca Channel, Seymour, Baltra Airport (Galapagos)
2026 Sails: Nov 28, Dec 12, Dec 26, More...
Lindblad Expeditions Tours, National Geographic Islander II Tours
National Geographic Islander II Tours12 Night - Epic Galapagos Escape
Starting in Quito, Ecuador, Quito / Galapagos Islands / Embark Ship, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito, Quito
2026 Sails: Nov 28, Dec 26, 2027: Jan 9, Jan 23, Feb 6, Feb 20, Mar 6, Mar 20, More...
MSC Cruises, MSC Virtuosa
MSC Virtuosa4 Night - Msc Grand Voyages
Starting in Salvador, Brazil, Rio De Janeiro, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Nov 28, More...
Carnival Cruise Lines, Carnival Liberty
Carnival Liberty14 Night - Journeys - Caribbean & Panama
Starting in New Orleans, La, Montego Bay, Jamaica, Aruba, Curacao, Cartagena CO, Colon (Panama Canal), Panama, Limon, Costa Rica, Cozumel, Mexico, New Orleans, La
2026 Sails: Nov 29, 2027: Nov 28, More...
Costa Cruise Lines, Costa Diadema
Costa Diadema4 Night - South America Roundtrip from Santos
Starting in Santos / Sao Paulo, Ilhabela, Brazil, Itajai, Brazil, Santos / Sao Paulo
2026 Sails: Nov 29, Dec 6, Dec 13, More...
HX Expeditions, MS Roald Amundsen
MS Roald Amundsen14 Night - Antarctica & Falkland Expedition
Starting in Ushuaia, South Shetland, Northern Gerlache, Southern Gerlache, South Shetland, West Point Island, Saunders Island, Port Stanley, Ushuaia
2026 Sails: Nov 29, More...
MSC Cruises, MSC Divina
MSC Divina4 Night - South America
Starting in Santos (Sao Paulo), Brazil, Ilha Grande, Brazil, Buzios, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Nov 29, 2027: Mar 4, More...

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South America Cruises