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South America Cruises

Cruises that visit South America

Cruises by region

See all South America River Cruises

Click on a cruise ship itinerary in South America (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just South America), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : South Georgia / South Sandwich Islands : Uruguay



MSC Seaview3 Night - South America
Starting in Santos (Sao Paulo), Brazil, Buzios, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Nov 29, More...
Delfin III Tours5 Night - Upper Amazon : a River Expedition
Starting in Lima, Peru, Lima / Iquitos / Nauta / Embark Ship, Pacaya-Samiria Reserve, Nauta / Disembark Ship / Iquitos / Lima
2026 Sails: Nov 30, Dec 7, More...
National Geographic Orion Tours9 Night - Antarctica Direct : Fly the Drake Passage
Starting in Puerto Natales, Chile, Puerto Natales / King George Island, Antarctica / Embark Ship, Antarctica, King George Island / Disembark Ship / Puerto Natales, Puerto Natales
2026 Sails: Dec 1, Dec 20, More...
World Voyager Quark Tours7 Night - Antarctic Express : Fly the Drake
Starting in Arrive in Punta Arenas, Chile, Fly to King George Island and Embarkation, Antarctic Peninsula and South Shetland Islands, Disembarkation and Fly to Punta Arenas, Depart Punta Arenas
2026 Sails: Dec 1, Dec 6, 2027: Feb 11, Feb 16, Feb 21, More...
Crystal Serenity8 Night - The Americas & Caribbean
Starting in Cartagena CO, Willemstad AN, Kralendijk, Oranjestad, Aruba, Santa Marta, Panama Canal Transit, Fuerte Amador (Panama City)
2026 Sails: Dec 2, More...
Crystal Serenity10 Night - The Americas & Caribbean
Starting in Cartagena CO, Willemstad AN, Kralendijk, Oranjestad, Aruba, Santa Marta, Panama Canal Transit, Fuerte Amador (Panama City), Puntarenas
2026 Sails: Dec 2, More...
National Geographic Endurance Tours11 Night - Voyage to Antarctica
Starting in Buenos Aires, Argentina or Santiago, Chile, Fly to Ushuaia, Argentina / Embark Ship, At Sea Crossing the Drake Passage, Antarctica, Ushuaia / Disembark Ship / Buenos Aires or Santiago
2026 Sails: Dec 2, Dec 12, Dec 22, 2027: Jan 1, Nov 15, Nov 25, Dec 19, Dec 29, 2028: Jan 8, Jan 18, Jan 28, Feb 7, Oct 29, Nov 8, Nov 18, Nov 28, Dec 8, 2029: Jan 1, More...
MSC Seaview3 Night - South America
Starting in Santos (Sao Paulo), Brazil, Camboriu, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Dec 2, More...
MSC Virtuosa3 Night - South America
Starting in Santos (Sao Paulo), Brazil, Buzios, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Dec 2, More...
Viking Jupiter17 Night - South America & the Chilean Fjords
Starting in Buenos Aires, Montevideo, Sail the Atlantic Ocean, Puerto Madryn, Sail the Atlantic Ocean, Port Stanley, Falkland Islands, Sail the Atlantic Ocean, Scenic Sailing Cape Horn, Ushuaia, Punta Arenas, Scenic Sailing Amalia Glacier, Scenic Sailing Chilean Fjords, Puerto Montt, Sail the Pacific Ocean, Santiago (Valparaiso)
2026 Sails: Dec 2, 2027: Jan 5, Feb 8, Dec 4, 2028: Jan 7, Feb 10, More...


South America Cruises