South America Cruises
Cruises that visit South America
Cruises by region
See all South America River Cruises
Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : South Georgia / South Sandwich Islands : Uruguay
15 Night - Wonders of Colombia with in Medellin, in Cartagena Pre Cruise and in Panama City Post Cruise
Starting in Medellin, Cartagena CO, Colombia, Mahates, Calamar, Magangue, Mompox, Santa Barbara de Pinto, Sitionuevo, Barranquilla, Panama City
2026 Sails: Nov 27, Dec 11, More...
12 Night - Wonders of Colombia with in Medellin, in Cartagena Pre Cruise
Starting in Medellin, Cartagena CO, Colombia, Mahates, Calamar, Magangue, Mompox, Santa Barbara de Pinto, Sitionuevo, Barranquilla
2026 Sails: Nov 27, Dec 11, More...
5 Night - The Americas & Caribbean
Starting in San Juan, Jost Van Dyke, British Virgin Islands, Oranjestad, Aruba, Cartagena CO
2026 Sails: Nov 27, More...
22 Night - In-Depth Antarctica, Falklands & South Georgia Expedition
Starting in Santiago De Chile Airport, Santiago, Santiago De Chile Airport, Punta Arenas Airport, Punta Arenas, New Island, West Point Island, Saunders Island, Carcass Island, Port Stanley, Cape Rosa, Prion Island, Godthul, Grytviken, Fortuna Bay, Stromness, St Andrews Bay, Antarctic Sound, South Shetland, Gerlache Strait, South Shetland, Puerto Williams, Punta Arenas, Punta Arenas Airport
2026 Sails: Nov 27, Dec 18, 2027: Jan 8, Jan 29, Nov 13, Dec 4, Dec 25, 2028: Jan 15, Feb 5, Feb 26, More...
13 Night - Galapagos Islands - in Darwin's Footsteps Plus Machu Picchu
Starting in Lima Airport, Lima, Lima Airport, Cusco Airport, Quito Airport, Quito, Quito Airport, Seymour, Mosquera, Puerto Baquerizo Moreno, Punta Pitt, San Cristobal Island, Santa Fe, South Plaza Island, Charles Darwin Research Station, Santa Cruz Island, Punta Suarez, Espanola Island, Gardner Bay, Espanola Island, Eden Islet, San Cristobal Island, Seymour Norte, Seymour, Baltra Airport (Galapagos)
2026 Sails: Nov 27, Dec 11, More...
15 Night - Exploring Galapagos, Machu Picchu and Peru's Land of the Inca
Starting in Quito, Ecuador, Quito / Galapagos Islands / Embark Ship, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito / Lima, Peru, Lima, Lima / Cusco / Sacred Valley, Sacred Valley, Sacred Valley / Machu Picchu, Machu Picchu / Cusco, Cusco, Cusco / Lima
2026 Sails: Nov 27, Dec 4, Dec 11, Dec 18, Dec 25, 2027: Jan 1, Jan 8, Jan 15, Jan 22, Jan 29, Feb 5, Feb 12, Feb 19, Feb 26, Mar 5, Mar 12, Mar 19, Mar 26, More...
9 Night - Exploring Galapagos
Starting in Quito, Ecuador, Quito / Galapagos Islands, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito, Quito
2026 Sails: Nov 27, Dec 4, Dec 11, Dec 18, Dec 25, 2027: Jan 1, Jan 8, Jan 15, Jan 22, Jan 29, Feb 5, Feb 12, Feb 19, Feb 26, Mar 5, Mar 12, Mar 19, Mar 26, More...
6 Night - Southeastern and Western Natural Selection Journey Roundtrip from Baltra Island & Santa Cruz Island
Starting in Baltra Island and Santa Cruz Island, San Cristobal Island, Espanola Island, Floreana Island, Isabela Island and Fernandina Island, Eden Islet and North Seymour Island, Baltra Airport
2026 Sails: Nov 27, Dec 11, Dec 25, 2027: Jan 8, Jan 22, Feb 5, Feb 19, Mar 5, Mar 19, Apr 2, Apr 16, Apr 30, May 14, May 28, Jun 11, Jun 25, Jul 9, Jul 23, Aug 6, Aug 20, Sep 3, Sep 17, Oct 1, Oct 15, More...
11 Night - Antarctica by Helicopter : Icebergs, Mountains and Remote Lands
Starting in Arrive in Buenos Aires, Argentina, Fly to Ushuaia and Embark, Crossing the Drake, Weddell Sea by Water, Land, and Air, Disembark in Ushuaia and Fly to Buenos Aires
2026 Sails: Nov 27, Dec 7, More...
7 Night - Magic of Colombia
Starting in Barranquilla, Sitionuevo, Magangue, Mompox, Santa Barbara de Pinto, Calamar, Palenque, Cartagena CO
2026 Sails: Nov 28, Dec 12, Dec 26, More...
Cruises that visit South America
Cruises by region
See all South America River Cruises
Click on a cruise ship itinerary in South America (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just South America), please visit: Cruise Search or try our Virtual Cruise Advisor™.
Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : South Georgia / South Sandwich Islands : Uruguay
15 Night - Wonders of Colombia with in Medellin, in Cartagena Pre Cruise and in Panama City Post CruiseStarting in Medellin, Cartagena CO, Colombia, Mahates, Calamar, Magangue, Mompox, Santa Barbara de Pinto, Sitionuevo, Barranquilla, Panama City
2026 Sails: Nov 27, Dec 11, More...
12 Night - Wonders of Colombia with in Medellin, in Cartagena Pre CruiseStarting in Medellin, Cartagena CO, Colombia, Mahates, Calamar, Magangue, Mompox, Santa Barbara de Pinto, Sitionuevo, Barranquilla
2026 Sails: Nov 27, Dec 11, More...
Deal link -> Special
5 Night - The Americas & CaribbeanStarting in San Juan, Jost Van Dyke, British Virgin Islands, Oranjestad, Aruba, Cartagena CO
2026 Sails: Nov 27, More...
22 Night - In-Depth Antarctica, Falklands & South Georgia ExpeditionStarting in Santiago De Chile Airport, Santiago, Santiago De Chile Airport, Punta Arenas Airport, Punta Arenas, New Island, West Point Island, Saunders Island, Carcass Island, Port Stanley, Cape Rosa, Prion Island, Godthul, Grytviken, Fortuna Bay, Stromness, St Andrews Bay, Antarctic Sound, South Shetland, Gerlache Strait, South Shetland, Puerto Williams, Punta Arenas, Punta Arenas Airport
2026 Sails: Nov 27, Dec 18, 2027: Jan 8, Jan 29, Nov 13, Dec 4, Dec 25, 2028: Jan 15, Feb 5, Feb 26, More...
13 Night - Galapagos Islands - in Darwin's Footsteps Plus Machu PicchuStarting in Lima Airport, Lima, Lima Airport, Cusco Airport, Quito Airport, Quito, Quito Airport, Seymour, Mosquera, Puerto Baquerizo Moreno, Punta Pitt, San Cristobal Island, Santa Fe, South Plaza Island, Charles Darwin Research Station, Santa Cruz Island, Punta Suarez, Espanola Island, Gardner Bay, Espanola Island, Eden Islet, San Cristobal Island, Seymour Norte, Seymour, Baltra Airport (Galapagos)
2026 Sails: Nov 27, Dec 11, More...
15 Night - Exploring Galapagos, Machu Picchu and Peru's Land of the IncaStarting in Quito, Ecuador, Quito / Galapagos Islands / Embark Ship, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito / Lima, Peru, Lima, Lima / Cusco / Sacred Valley, Sacred Valley, Sacred Valley / Machu Picchu, Machu Picchu / Cusco, Cusco, Cusco / Lima
2026 Sails: Nov 27, Dec 4, Dec 11, Dec 18, Dec 25, 2027: Jan 1, Jan 8, Jan 15, Jan 22, Jan 29, Feb 5, Feb 12, Feb 19, Feb 26, Mar 5, Mar 12, Mar 19, Mar 26, More...
9 Night - Exploring GalapagosStarting in Quito, Ecuador, Quito / Galapagos Islands, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito, Quito
2026 Sails: Nov 27, Dec 4, Dec 11, Dec 18, Dec 25, 2027: Jan 1, Jan 8, Jan 15, Jan 22, Jan 29, Feb 5, Feb 12, Feb 19, Feb 26, Mar 5, Mar 12, Mar 19, Mar 26, More...
6 Night - Southeastern and Western Natural Selection Journey Roundtrip from Baltra Island & Santa Cruz IslandStarting in Baltra Island and Santa Cruz Island, San Cristobal Island, Espanola Island, Floreana Island, Isabela Island and Fernandina Island, Eden Islet and North Seymour Island, Baltra Airport
2026 Sails: Nov 27, Dec 11, Dec 25, 2027: Jan 8, Jan 22, Feb 5, Feb 19, Mar 5, Mar 19, Apr 2, Apr 16, Apr 30, May 14, May 28, Jun 11, Jun 25, Jul 9, Jul 23, Aug 6, Aug 20, Sep 3, Sep 17, Oct 1, Oct 15, More...
11 Night - Antarctica by Helicopter : Icebergs, Mountains and Remote LandsStarting in Arrive in Buenos Aires, Argentina, Fly to Ushuaia and Embark, Crossing the Drake, Weddell Sea by Water, Land, and Air, Disembark in Ushuaia and Fly to Buenos Aires
2026 Sails: Nov 27, Dec 7, More...
7 Night - Magic of ColombiaStarting in Barranquilla, Sitionuevo, Magangue, Mompox, Santa Barbara de Pinto, Calamar, Palenque, Cartagena CO
2026 Sails: Nov 28, Dec 12, Dec 26, More...