South America Cruises
Cruises that visit South America
Cruises by region
See all South America River Cruises
Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : South Georgia / South Sandwich Islands : Uruguay
10 Night - A Journey of Caribbean Charm & Spectacular Natural Beauty
Starting in Miami, Willemstad AN, Oranjestad, Santa Marta, Cartagena CO, George Town, Grand Cayman, Miami
2026 Sails: Nov 25, More...
27 Night - Legendary Amazon Explorer
Starting in Fort Lauderdale, Florida, Philipsburg, Sint Maarten, Fort-De-France, Martinique, Bridgetown, Barbados, Crossing the Amazon River Bar, Brazil, Cruising the Amazon River, Macapa, Brazil, Cruising the Amazon River, Crossing the Equator, Cruising the Amazon River, Santarem, Brazil, Boca da Valeria, Brazil, Manaus, Brazil, Parintins, Brazil, Alter Do Chao, Brazil, Crossing the Equator, Cruising the Amazon River, Crossing the Amazon River Bar, Brazil, Devils Island, French Guiana, Port-of-Spain, Trinidad and Tobago, Willemstad AN, Curacao, Fort Lauderdale, Florida
2026 Sails: Nov 25, More...
7 Night - Antarctica Direct : Fly the Drake Passage
Starting in Puerto Natales, Chile, Puerto Natales / King George Island, Antarctica / Embark Ship, Antarctica, King George Island / Disembark Ship / Puerto Natales, Puerto Natales
2026 Sails: Nov 25, Nov 30, Dec 14, 2027: Jan 2, Jan 21, Feb 9, Nov 26, Dec 15, 2028: Jan 3, Jan 22, Feb 10, Feb 29, More...
4 Night - Galapagos from Quito to Guayaquil
Starting in Quito Airport, Seymour, Dragon Hill, Punta Vicente Roca, Fernandina, Puerto Ayora, Isla Santa Cruz, Post Office Bay, Champion Islet, Punta Cormorant, Seymour, Baltra Airport (Galapagos)
2026 Sails: Nov 26, Dec 10, Dec 24, More...
8 Night - Galapagos from Quito to Guayaquil
Starting in Quito Airport, Seymour, Dragon Hill, Punta Vicente Roca, Fernandina, Puerto Ayora, Isla Santa Cruz, Post Office Bay, Champion Islet, Punta Cormorant, Seymour, Las Bachas, Santa Cruz Island, Buccaneer Cove, Puerto Egas, Rabida Island, Bartolome Island, Prince Philip Steps, Genovesa Island, Darwin Bay, Genovesa Island, Itabaca Channel, Seymour, Baltra Airport (Galapagos)
2026 Sails: Nov 26, Dec 10, More...
9 Night - Exploring Peru : Machu Picchu and the Amazon
Starting in Lima, Peru, Lima / Cusco / Sacred Valley, Machu Picchu, Sacred Valley / Cusco, Cusco, Cusco / Lima / Iquitos / Nauta / Embark Ship, Pacaya-Samiria Reserve, Nauta / Disembark Ship / Iquitos / Lima
2026 Sails: Nov 26, Dec 3, More...
11 Night - Voyage to Antarctica
Starting in Buenos Aires, Argentina or Santiago, Chile, Fly to Ushuaia, Argentina / Embark Ship, At Sea Crossing the Drake Passage, Antarctica, Ushuaia / Disembark Ship / Buenos Aires or Santiago
2026 Sails: Nov 26, Dec 6, Dec 16, Dec 26, 2027: Jan 5, Feb 7, Oct 15, Oct 25, Nov 4, Nov 28, Dec 8, Dec 18, Dec 28, 2028: Jan 21, Feb 23, Mar 4, Oct 14, Oct 24, Nov 17, Dec 17, Dec 27, 2029: Jan 6, Jan 16, Feb 18, More...
4 Night - Southeastern Galapagos Origin of Species Adventure Roundtrip from Baltra & South Plaza Islands
Starting in Baltra and South Plaza Islands, Santa Fe and San Cristobal, San Cristobal Island, Espanola Island, Santa Cruz Island and Baltra Island
2026 Sails: Nov 26, Dec 10, Dec 24, 2027: Jan 7, Jan 21, Feb 4, Feb 18, Mar 4, Mar 18, Apr 1, Apr 15, Apr 29, May 13, May 27, Jun 10, Jun 24, Jul 8, Jul 22, Aug 5, Aug 19, Sep 2, Sep 16, Sep 30, Oct 14, More...
4 Night - South America
Starting in Santos (Sao Paulo), Brazil, Buzios, Brazil, Ilha Grande, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Nov 26, Dec 6, 2027: Dec 9, More...
22 Night - Patagonian Adventure and Antarctica's Weddell Sea - Cruise & Land Journey
Starting in Santiago, Chile, Santiago / Torres del Paine National Park, Torres del Paine National Park, Torres del Paine National Park / El Calafate, Argentina, El Calafate, El Calafate / Ushuaia, Antarctica, At Sea / Ushuaia, Ushuaia, Argentina / Buenos Aires
2026 Sails: Nov 26, More...
Cruises that visit South America
Cruises by region
See all South America River Cruises
Click on a cruise ship itinerary in South America (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just South America), please visit: Cruise Search or try our Virtual Cruise Advisor™.
Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : South Georgia / South Sandwich Islands : Uruguay
10 Night - A Journey of Caribbean Charm & Spectacular Natural BeautyStarting in Miami, Willemstad AN, Oranjestad, Santa Marta, Cartagena CO, George Town, Grand Cayman, Miami
2026 Sails: Nov 25, More...
27 Night - Legendary Amazon ExplorerStarting in Fort Lauderdale, Florida, Philipsburg, Sint Maarten, Fort-De-France, Martinique, Bridgetown, Barbados, Crossing the Amazon River Bar, Brazil, Cruising the Amazon River, Macapa, Brazil, Cruising the Amazon River, Crossing the Equator, Cruising the Amazon River, Santarem, Brazil, Boca da Valeria, Brazil, Manaus, Brazil, Parintins, Brazil, Alter Do Chao, Brazil, Crossing the Equator, Cruising the Amazon River, Crossing the Amazon River Bar, Brazil, Devils Island, French Guiana, Port-of-Spain, Trinidad and Tobago, Willemstad AN, Curacao, Fort Lauderdale, Florida
2026 Sails: Nov 25, More...
7 Night - Antarctica Direct : Fly the Drake PassageStarting in Puerto Natales, Chile, Puerto Natales / King George Island, Antarctica / Embark Ship, Antarctica, King George Island / Disembark Ship / Puerto Natales, Puerto Natales
2026 Sails: Nov 25, Nov 30, Dec 14, 2027: Jan 2, Jan 21, Feb 9, Nov 26, Dec 15, 2028: Jan 3, Jan 22, Feb 10, Feb 29, More...
4 Night - Galapagos from Quito to GuayaquilStarting in Quito Airport, Seymour, Dragon Hill, Punta Vicente Roca, Fernandina, Puerto Ayora, Isla Santa Cruz, Post Office Bay, Champion Islet, Punta Cormorant, Seymour, Baltra Airport (Galapagos)
2026 Sails: Nov 26, Dec 10, Dec 24, More...
8 Night - Galapagos from Quito to GuayaquilStarting in Quito Airport, Seymour, Dragon Hill, Punta Vicente Roca, Fernandina, Puerto Ayora, Isla Santa Cruz, Post Office Bay, Champion Islet, Punta Cormorant, Seymour, Las Bachas, Santa Cruz Island, Buccaneer Cove, Puerto Egas, Rabida Island, Bartolome Island, Prince Philip Steps, Genovesa Island, Darwin Bay, Genovesa Island, Itabaca Channel, Seymour, Baltra Airport (Galapagos)
2026 Sails: Nov 26, Dec 10, More...
9 Night - Exploring Peru : Machu Picchu and the AmazonStarting in Lima, Peru, Lima / Cusco / Sacred Valley, Machu Picchu, Sacred Valley / Cusco, Cusco, Cusco / Lima / Iquitos / Nauta / Embark Ship, Pacaya-Samiria Reserve, Nauta / Disembark Ship / Iquitos / Lima
2026 Sails: Nov 26, Dec 3, More...
11 Night - Voyage to AntarcticaStarting in Buenos Aires, Argentina or Santiago, Chile, Fly to Ushuaia, Argentina / Embark Ship, At Sea Crossing the Drake Passage, Antarctica, Ushuaia / Disembark Ship / Buenos Aires or Santiago
2026 Sails: Nov 26, Dec 6, Dec 16, Dec 26, 2027: Jan 5, Feb 7, Oct 15, Oct 25, Nov 4, Nov 28, Dec 8, Dec 18, Dec 28, 2028: Jan 21, Feb 23, Mar 4, Oct 14, Oct 24, Nov 17, Dec 17, Dec 27, 2029: Jan 6, Jan 16, Feb 18, More...
4 Night - Southeastern Galapagos Origin of Species Adventure Roundtrip from Baltra & South Plaza IslandsStarting in Baltra and South Plaza Islands, Santa Fe and San Cristobal, San Cristobal Island, Espanola Island, Santa Cruz Island and Baltra Island
2026 Sails: Nov 26, Dec 10, Dec 24, 2027: Jan 7, Jan 21, Feb 4, Feb 18, Mar 4, Mar 18, Apr 1, Apr 15, Apr 29, May 13, May 27, Jun 10, Jun 24, Jul 8, Jul 22, Aug 5, Aug 19, Sep 2, Sep 16, Sep 30, Oct 14, More...
4 Night - South AmericaStarting in Santos (Sao Paulo), Brazil, Buzios, Brazil, Ilha Grande, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Nov 26, Dec 6, 2027: Dec 9, More...
22 Night - Patagonian Adventure and Antarctica's Weddell Sea - Cruise & Land JourneyStarting in Santiago, Chile, Santiago / Torres del Paine National Park, Torres del Paine National Park, Torres del Paine National Park / El Calafate, Argentina, El Calafate, El Calafate / Ushuaia, Antarctica, At Sea / Ushuaia, Ushuaia, Argentina / Buenos Aires
2026 Sails: Nov 26, More...