South America Cruises
Cruises that visit South America
Cruises by region
See all South America River Cruises
Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : Suriname : Uruguay
131 Night - Msc World Cruise
Starting in Barcelona, Spain, Funchal (Madeira Islands), Portugal, Bridgetown, Barbados, Saint George, Grenada, Willemstad AN, Curacao, Cartagena CO, Puerto Limon, Costa Rica, Cruising Panama Canal, Puntarenas (San Jose), Costa Rica, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, Los Angeles, Hilo, Hawaii, Pago Pago, American Samoa, Apia, Western Samoa, Suva, Fiji, Auckland, New Zealand, Wellington, New Zealand, Sydney AU, Australia, Townsville, Australia, Cairns, Australia, Manila, Philippines, Keelung (Taipei) Taiwan, China, Ishigaki, Japan, Naha (Okinawa), Japan, Tokyo, Japan, Nagasaki, Japan, Busan, South Korea, Shanghai, China, Hong Kong, China, Da Nang, Vietnam, Singapore, Port Klang (Kuala Lumpur), Malaysia, Penang, Malaysia, Port Victoria, Seychelles, Port Louis, Mauritius, La Possession, Reunion, Cape Town, South Africa, Walvis Bay, Namibia, Mindelo, Cape Verde, Civitavecchia (Rome), Italy, Livorno (Florence), Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Barcelona, Spain
2026 Sails: Jan 7, More...89 Night - Msc World Cruise
Starting in Barcelona, Spain, Funchal (Madeira Islands), Portugal, Bridgetown, Barbados, Saint Georges, Grenada, Willemstad AN, Curacao, Cartagena CO, Puerto Limon, Costa Rica, Cruising Panama Canal, Puntarenas (San Jose), Costa Rica, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, Los Angeles, Hilo, Hawaii, Pago Pago, American Samoa, Apia, Western Samoa, Suva, Fiji, Auckland, New Zealand, Wellington, New Zealand, Sydney AU, Australia, Townsville, Australia, Cairns, Australia, Manila, Philippines, Keelung (Taipei) Taiwan, China, Ishigaki, Japan, Naha (Okinawa), Japan, Tokyo, Japan, Nagasaki, Japan, Busan, South Korea, Shanghai, China, Hong Kong, China, Da Nang, Vietnam, Singapore
2026 Sails: Jan 7, More...
7 Night - South America
Starting in Maceio, Brazil, Santos (Sao Paulo), Brazil, Buzios, Brazil, Salvador, Brazil, Maceio, Brazil
2026 Sails: Jan 7, Jan 14, Jan 28, Feb 4, Feb 11, Feb 18, Feb 25, Mar 4, Mar 25, Apr 1, More...
18 Night - Ushuaia Roundtrip
Starting in Ushuaia, Drake Passage Navigation, Antarctic Peninsula / Captains Choice, South Georgia / Captains Choice, Port Stanley, Falkland Islands, Ushuaia
2026 Sails: Jan 8, More...
11 Night - Voyage to Antarctica
Starting in Buenos Aires, Argentina or Santiago, Chile, Fly to Ushuaia, Argentina / Embark Ship, At Sea Crossing the Drake Passage, Antarctica, Ushuaia / Disembark Ship / Buenos Aires or Santiago
2026 Sails: Jan 8, Jan 18, Jan 28, Dec 2, Dec 12, Dec 22, 2027: Jan 1, Nov 15, Nov 25, Dec 19, Dec 29, 2028: Jan 8, Jan 18, Jan 28, Feb 7, More...
4 Night - Southeastern Humboldt Isles Expedition Roundtrip from Baltra & South Plaza Islands
Starting in Baltra and South Plaza Islands, Santa Fe and San Cristobal, San Cristobal Island, Espanola Island, Santa Cruz Island / Baltra Island
2026 Sails: Jan 8, Jan 22, Feb 5, Feb 19, Mar 5, Mar 19, Apr 12, Apr 16, Apr 30, May 14, May 28, Jun 11, Jul 9, Jul 23, Aug 6, Aug 20, Sep 3, Sep 17, Oct 1, Oct 15, Oct 29, Nov 12, Nov 26, Dec 10, More...
7 Night - South America
Starting in Rio De Janeiro, Brazil, Buzios, Brazil, Itajai, Brazil, Santos (Sao Paulo), Brazil, Ilhabela, Brazil, Ilha Grande, Brazil, Rio De Janeiro, Brazil
2026 Sails: Jan 8, More...
17 Night - Antarctica & South America
Starting in Buenos Aires, Argentina, Punta Arenas, Chile, Ushuaia (Tierra del Fuego), Argentina, Antarctic Peninsula (Scenic Cruising), Port Stanley, Falkland Islands, Montevideo, Uruguay, Buenos Aires, Argentina
2026 Sails: Jan 8, Jan 25, More...
22 Night - South America & Antarctica
Starting in San Antonio CL (Santiago), Chile, Puerto Montt, Chile, Puerto Chacabuco, Chile, Cruising Chilean Fjords, Scenic cruising Amalia or Brujo Glacier, Scenic cruising Sarmiento Channel, Strait of Magellan, Punta Arenas, Chile, Cockburn Channel, Beagle Channel, Daylight cruising Glacier Alley, Ushuaia, Argentina, Cape Horn and Drake Passage, Antarctic, Port Stanley, Falkland Islands, Puerto Madryn, Argentina, Punta Del Este, Uruguay, Montevideo, Uruguay, Buenos Aires, Argentina
2026 Sails: Jan 9, More...
6 Night - Southeastern and Western Natural Selection Journey Roundtrip from Baltra Island & Santa Cruz Island
Starting in Baltra Island and Santa Cruz Island, San Cristobal Island, Espanola Island, Floreana Island, Isabela Island and Fernandina Island, Eden Islet and North Seymour Island, Baltra Airport
2026 Sails: Jan 9, Jan 23, Feb 6, Feb 20, Mar 6, Mar 20, Apr 3, Apr 17, May 1, May 15, May 29, Jun 12, Jun 26, Jul 10, Jul 24, Aug 7, Aug 21, Sep 4, Sep 18, Oct 2, Oct 16, Oct 30, Nov 13, Nov 27, More...
Cruises that visit South America
Cruises by region
See all South America River Cruises
Click on a cruise ship itinerary in South America (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just South America), please visit: Cruise Search or try our Virtual Cruise Advisor™.
Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : Suriname : Uruguay
131 Night - Msc World CruiseStarting in Barcelona, Spain, Funchal (Madeira Islands), Portugal, Bridgetown, Barbados, Saint George, Grenada, Willemstad AN, Curacao, Cartagena CO, Puerto Limon, Costa Rica, Cruising Panama Canal, Puntarenas (San Jose), Costa Rica, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, Los Angeles, Hilo, Hawaii, Pago Pago, American Samoa, Apia, Western Samoa, Suva, Fiji, Auckland, New Zealand, Wellington, New Zealand, Sydney AU, Australia, Townsville, Australia, Cairns, Australia, Manila, Philippines, Keelung (Taipei) Taiwan, China, Ishigaki, Japan, Naha (Okinawa), Japan, Tokyo, Japan, Nagasaki, Japan, Busan, South Korea, Shanghai, China, Hong Kong, China, Da Nang, Vietnam, Singapore, Port Klang (Kuala Lumpur), Malaysia, Penang, Malaysia, Port Victoria, Seychelles, Port Louis, Mauritius, La Possession, Reunion, Cape Town, South Africa, Walvis Bay, Namibia, Mindelo, Cape Verde, Civitavecchia (Rome), Italy, Livorno (Florence), Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Barcelona, Spain
2026 Sails: Jan 7, More...
89 Night - Msc World CruiseStarting in Barcelona, Spain, Funchal (Madeira Islands), Portugal, Bridgetown, Barbados, Saint Georges, Grenada, Willemstad AN, Curacao, Cartagena CO, Puerto Limon, Costa Rica, Cruising Panama Canal, Puntarenas (San Jose), Costa Rica, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, Los Angeles, Hilo, Hawaii, Pago Pago, American Samoa, Apia, Western Samoa, Suva, Fiji, Auckland, New Zealand, Wellington, New Zealand, Sydney AU, Australia, Townsville, Australia, Cairns, Australia, Manila, Philippines, Keelung (Taipei) Taiwan, China, Ishigaki, Japan, Naha (Okinawa), Japan, Tokyo, Japan, Nagasaki, Japan, Busan, South Korea, Shanghai, China, Hong Kong, China, Da Nang, Vietnam, Singapore
2026 Sails: Jan 7, More...
7 Night - South AmericaStarting in Maceio, Brazil, Santos (Sao Paulo), Brazil, Buzios, Brazil, Salvador, Brazil, Maceio, Brazil
2026 Sails: Jan 7, Jan 14, Jan 28, Feb 4, Feb 11, Feb 18, Feb 25, Mar 4, Mar 25, Apr 1, More...
18 Night - Ushuaia RoundtripStarting in Ushuaia, Drake Passage Navigation, Antarctic Peninsula / Captains Choice, South Georgia / Captains Choice, Port Stanley, Falkland Islands, Ushuaia
2026 Sails: Jan 8, More...
11 Night - Voyage to AntarcticaStarting in Buenos Aires, Argentina or Santiago, Chile, Fly to Ushuaia, Argentina / Embark Ship, At Sea Crossing the Drake Passage, Antarctica, Ushuaia / Disembark Ship / Buenos Aires or Santiago
2026 Sails: Jan 8, Jan 18, Jan 28, Dec 2, Dec 12, Dec 22, 2027: Jan 1, Nov 15, Nov 25, Dec 19, Dec 29, 2028: Jan 8, Jan 18, Jan 28, Feb 7, More...
4 Night - Southeastern Humboldt Isles Expedition Roundtrip from Baltra & South Plaza IslandsStarting in Baltra and South Plaza Islands, Santa Fe and San Cristobal, San Cristobal Island, Espanola Island, Santa Cruz Island / Baltra Island
2026 Sails: Jan 8, Jan 22, Feb 5, Feb 19, Mar 5, Mar 19, Apr 12, Apr 16, Apr 30, May 14, May 28, Jun 11, Jul 9, Jul 23, Aug 6, Aug 20, Sep 3, Sep 17, Oct 1, Oct 15, Oct 29, Nov 12, Nov 26, Dec 10, More...
7 Night - South AmericaStarting in Rio De Janeiro, Brazil, Buzios, Brazil, Itajai, Brazil, Santos (Sao Paulo), Brazil, Ilhabela, Brazil, Ilha Grande, Brazil, Rio De Janeiro, Brazil
2026 Sails: Jan 8, More...
17 Night - Antarctica & South AmericaStarting in Buenos Aires, Argentina, Punta Arenas, Chile, Ushuaia (Tierra del Fuego), Argentina, Antarctic Peninsula (Scenic Cruising), Port Stanley, Falkland Islands, Montevideo, Uruguay, Buenos Aires, Argentina
2026 Sails: Jan 8, Jan 25, More...
22 Night - South America & AntarcticaStarting in San Antonio CL (Santiago), Chile, Puerto Montt, Chile, Puerto Chacabuco, Chile, Cruising Chilean Fjords, Scenic cruising Amalia or Brujo Glacier, Scenic cruising Sarmiento Channel, Strait of Magellan, Punta Arenas, Chile, Cockburn Channel, Beagle Channel, Daylight cruising Glacier Alley, Ushuaia, Argentina, Cape Horn and Drake Passage, Antarctic, Port Stanley, Falkland Islands, Puerto Madryn, Argentina, Punta Del Este, Uruguay, Montevideo, Uruguay, Buenos Aires, Argentina
2026 Sails: Jan 9, More...
6 Night - Southeastern and Western Natural Selection Journey Roundtrip from Baltra Island & Santa Cruz IslandStarting in Baltra Island and Santa Cruz Island, San Cristobal Island, Espanola Island, Floreana Island, Isabela Island and Fernandina Island, Eden Islet and North Seymour Island, Baltra Airport
2026 Sails: Jan 9, Jan 23, Feb 6, Feb 20, Mar 6, Mar 20, Apr 3, Apr 17, May 1, May 15, May 29, Jun 12, Jun 26, Jul 10, Jul 24, Aug 7, Aug 21, Sep 4, Sep 18, Oct 2, Oct 16, Oct 30, Nov 13, Nov 27, More...
