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South America Cruises

Cruises that visit South America

Cruises by region

See all South America River Cruises

Click on a cruise ship itinerary in South America (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just South America), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : Uruguay



Viking Ocean, Viking Polaris
Viking Polaris19 Night - Panama Canal & the Americas
Starting in New York City, New York, Sail the Atlantic Ocean, San Salvador Island, Man of War Bay (Great Inagua), Port Antonio, Sail the Caribbean Sea, Scenic Sailing Panama Canal, Panama City (Fuerte Amador), Sail the Pacific Ocean, Lima (Callao), Sail the Pacific Ocean, Iquique, Sail the Pacific Ocean, Santiago (Valparaiso)
2026 Sails: Oct 25, More...
PONANT, Le Bellot
Le Bellot12 Night - Panama, Colombia & Caribbean Islands
Starting in Fort-de-France, Les Saintes, Pigeon Island Beach, Sailing along the Pitons, Port Elizabeth VC, Bequia Island, Mayreau Island, Bonaire, Santa Marta, Cartagena CO, San Blas Islands, Portobelo, Colon
2026 Sails: Oct 26, More...
Scenic Luxury, Scenic Eclipse II
Scenic Eclipse II36 Night - Machu Picchu, Amazon & Antarctic Odyssey - Cruise & Land Journey
Starting in Lima, Lima / Sacred Valley, Sacred Valley, Sacred Valley / Machu Picchu, Machu Picchu / Cuzco, Cuzco, Cuzco / Amazon, Amazon, Amazon / Buenos Aires, Buenos Aires, Falkland Islands, South Georgia, Antarctica, At Sea / Ushuaia, Ushuaia, Argentina / Buenos Aires
2026 Sails: Oct 26, More...
AmaWaterways, AmaMelodia
AmaMelodia7 Night - Magic of Colombia
Starting in Barranquilla, Sitionuevo, Magangue, Mompox, Santa Barbara de Pinto, Calamar, Palenque, Cartagena CO
2026 Sails: Oct 28, Nov 11, Nov 25, Dec 23, More...
AmaWaterways Tours, AmaMelodia Tours
AmaMelodia Tours10 Night - Magic of Colombia with Panama Post Cruise
Starting in Barranquilla, Sitionuevo, Magangue, Mompox, Santa Barbara de Pinto, Calamar, Mahates, Cartagena CO, Colombia, Panama City
2026 Sails: Oct 28, Nov 11, Nov 25, More...
MSC Cruises, MSC Divina
MSC Divina18 Night - Msc Grand Voyages
Starting in Naples (Pompeii), Italy, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Tarragona, Spain, Santa Cruz de Tenerife, Salvador, Brazil, Rio De Janeiro, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Oct 29, More...
MSC Cruises, MSC Divina
MSC Divina17 Night - Msc Grand Voyages
Starting in Naples (Pompeii), Italy, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Tarragona, Spain, Santa Cruz de Tenerife, Salvador, Brazil, Rio De Janeiro, Brazil
2026 Sails: Oct 29, More...
Silversea, Silver Wind
Silver Wind9 Night - King George Island to Puerto Williams
Starting in King George Island, Antarctic Sound, Antarctic Peninsula, South Shetland Islands, Drake Passage, Puerto Williams
2026 Sails: Oct 29, 2027: Jan 15, Feb 2, Feb 20, Mar 10, Nov 13, Dec 1, Dec 19, 2028: Jan 6, Jan 24, Feb 11, Feb 29, More...
Virgin Voyages, Brilliant Lady
Brilliant Lady17 Night - Panama Canal : La to Miami Halloween
Starting in Los Angeles, California, Cabo San Lucas, Mexico, Puerto Quetzal, Guatemala, Puntarenas, Costa Rica, Panama City, Panama, Panama Canal (Cruising), Panama, Cartagena CO, Miami, Florida
2026 Sails: Oct 29, More...
AmaWaterways Tours, AmaMelodia Tours
AmaMelodia Tours15 Night - Wonders of Colombia with in Medellin, in Cartagena Pre Cruise and in Panama City Post Cruise
Starting in Medellin, Cartagena CO, Colombia, Mahates, Calamar, Magangue, Mompox, Santa Barbara de Pinto, Sitionuevo, Barranquilla, Panama City
2026 Sails: Oct 30, Nov 13, Nov 27, Dec 11, More...

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South America Cruises