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South America Cruises

Cruises that visit South America

Cruises by region

See all South America River Cruises

Click on a cruise ship itinerary in South America (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just South America), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : Uruguay



Costa Cruise Lines, Costa Diadema
Costa Diadema7 Night - South America Roundtrip from Santos
Starting in Santos / Sao Paulo, Buenos Aires, Argentina, Montevideo, Uruguay, Itajai, Brazil, Santos / Sao Paulo
2026 Sails: Dec 20, Dec 27, 2027: Jan 3, Jan 10, Jan 17, Jan 24, Jan 31, Feb 7, Feb 14, Feb 21, Feb 28, Mar 7, Mar 14, More...
Nieuw Amsterdam19 Night - Panama Canal Holiday : Amber Cove & Costa Rica
Starting in Fort Lauderdale, Florida, RelaxAway, Half Moon Cay, Bahamas, Grand Turk, Turks and Caicos, Amber Cove, Dominican Republic, Key West, Florida, Fort Lauderdale, Florida, RelaxAway, Half Moon Cay, Bahamas, Oranjestad, Aruba, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal and Gatun Lake, Gatun Lake, Panama, Cruising Gatun Lake and Panama Canal, Exit Panama Canal Cristobal, Colon, Panama, Puerto Limon (San Jose), Costa Rica, Georgetown, Cayman Islands, Fort Lauderdale, Florida
2026 Sails: Dec 20, More...
MSC Cruises, MSC Musica
MSC Musica2 Night - South America
Starting in Santos (Sao Paulo), Brazil, Ilhabela, Brazil, Rio De Janeiro, Brazil
2026 Sails: Dec 20, More...
MSC Cruises, MSC Musica
MSC Musica6 Night - South America
Starting in Santos (Sao Paulo), Brazil, Ilhabela, Brazil, Rio De Janeiro, Brazil, Ilha Grande, Brazil, Buzios, Brazil, Paranagua, Brazil
2026 Sails: Dec 20, More...
MSC Cruises, MSC Musica
MSC Musica7 Night - South America
Starting in Santos (Sao Paulo), Brazil, Ilhabela, Brazil, Rio De Janeiro, Brazil, Ilha Grande, Brazil, Buzios, Brazil, Paranagua, Brazil, Itajai, Brazil
2026 Sails: Dec 20, More...
MSC Cruises, MSC Seaview
MSC Seaview7 Night - South America
Starting in Santos (Sao Paulo), Brazil, Camboriu, Brazil, Punta Del Este, Uruguay, Buenos Aires, Argentina, Santos (Sao Paulo), Brazil
2026 Sails: Dec 20, Dec 27, More...
PONANT, Le Boreal
Le Boreal17 Night - The Great Austral Loop
Starting in Ushuaia, Grave Cove, New Island, South Georgia, Antarctic Peninsula, Crossing the Drake Passage, Ushuaia
2026 Sails: Dec 20, 2027: Feb 15, More...
Royal Caribbean, Grandeur of the Seas
Grandeur of the Seas7 Night - Southern Caribbean Cruise
Starting in Cartagena CO, Santa Marta, Colombia, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama, Cartagena CO
2026 Sails: Dec 20, 2027: Jan 31, More...
MSC Cruises, MSC Divina
MSC Divina5 Night - South America
Starting in Santos (Sao Paulo), Brazil, Ilha Grande, Brazil, Buzios, Brazil, Ilhabela, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Dec 21, More...
MSC Cruises, MSC Seaview
MSC Seaview7 Night - South America
Starting in Camboriu, Brazil, Punta Del Este, Uruguay, Buenos Aires, Argentina, Santos (Sao Paulo), Brazil, Camboriu, Brazil
2026 Sails: Dec 21, Dec 28, More...

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South America Cruises