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South America Cruises

Cruises that visit South America

Cruises by region

See all South America River Cruises

Click on a cruise ship itinerary in South America (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just South America), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : Uruguay



Costa Cruise Lines, Costa Diadema
Costa Diadema3 Night - South America Roundtrip from Santos
Starting in Santos, Brazil, Itajai, Brazil, Santos, Brazil
2026 Sails: Nov 23, Nov 26, Dec 3, Dec 10, Dec 17, More...
Crystal Cruises, Crystal Serenity
Crystal Serenity19 Night - The Americas & Caribbean
Starting in Fort Lauderdale, Nassau (Paradise Island), Samana, San Juan, Jost Van Dyke, British Virgin Islands, Oranjestad, Aruba, Cartagena CO, Willemstad AN, Kralendijk, Oranjestad, Aruba, Santa Marta, Panama Canal Transit, Fuerte Amador (Panama City), Puerto Caldera
2026 Sails: Nov 23, More...
Crystal Cruises, Crystal Serenity
Crystal Serenity9 Night - The Americas & Caribbean
Starting in Fort Lauderdale, Nassau (Paradise Island), Samana, San Juan, Jost Van Dyke, British Virgin Islands, Oranjestad, Aruba, Cartagena CO
2026 Sails: Nov 23, More...
Crystal Cruises, Crystal Serenity
Crystal Serenity28 Night - The Americas & Caribbean
Starting in Fort Lauderdale, Nassau (Paradise Island), Samana, San Juan, Jost Van Dyke, British Virgin Islands, Oranjestad, Aruba, Cartagena CO, Willemstad AN, Kralendijk, Oranjestad, Aruba, Santa Marta, Panama Canal Transit, Fuerte Amador (Panama City), Puerto Caldera, Playa Flamingo, Acajutla, Zihuatanejo, Manzanillo, Puerto Vallarta, San Diego
2026 Sails: Nov 23, More...
MSC Cruises, MSC Musica
MSC Musica3 Night - South America
Starting in Santos (Sao Paulo), Brazil, Buzios, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Nov 23, More...
Princess Cruises, Caribbean Princess
Caribbean Princess12 Night - Caribbean with Costa Rica & Panama Canal Holiday
Starting in Fort Lauderdale, Florida, Aruba, Cartagena CO, Panama Canal Partial Transit New Locks, Colon, Panama, Limon, Costa Rica, Celebration Key, Bahamas, Fort Lauderdale, Florida
2026 Sails: Nov 23, 2027: Jan 22, More...
Viking Ocean, Viking Octantis
Viking Octantis12 Night - Chilean Fjords & Scenic Shores
Starting in Santiago (Valparaiso), Sail the Pacific Ocean, Scenic Sailing Chilean Fjords, Puerto Chacabuco, Scenic Sailing Chilean Fjords, Chilean Glaciers, Scenic Sailing Chilean Fjords, Punta Arenas, Chilean Glaciers, Garibaldi Fjord, Scenic Sailing Cape Horn, Ushuaia
2026 Sails: Nov 23, More...
Oceania Insignia25 Night - Amazon & Caribbean Isles
Starting in Miami, Tortola, St Johns, Castries, Scarborough, Cruising the Amazon River, Santarem (Amazon River), Boca Da Valeria (Amazon River), Manaus (Amazon River), Parintins (Amazon River), Alter Do Chao (Amazon River), Cruising the Amazon River, Bridgetown, Roseau, Philipsburg, San Juan, Nassau, Miami
2026 Sails: Nov 24, More...
Quark Expeditions Tours, World Voyager Quark Tours
World Voyager Quark Tours9 Night - Antarctic Express : Sail South, Fly North
Starting in Arriving in Buenos Aires and Hotel, Arrive in Ushuaia and Embarkation, Crossing the Drake Passage, South Shetland Islands and Antarctic Peninsula, Disembarkation and Fly to Punta Arenas, Depart Punta Arenas
2026 Sails: Nov 24, 2027: Dec 2, 2028: Feb 5, More...
Windstar, Wind Star
Wind Star11 Night - Colombian & Southern Caribbean Coastlines
Starting in Bridgetown, Bequia, St Georges, Kralendijk, Willemstad AN, Oranjestad, Cartagena CO, San Blas, Panama, Colon
2026 Sails: Nov 24, More...

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South America Cruises