South America Cruises
Cruises that visit South America
Cruises by region
See all South America River Cruises
Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : Uruguay
9 Night - Exploring Galapagos
Starting in Quito, Ecuador, Quito / Galapagos Islands, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito, Quito
2026 Sails: Oct 2, Oct 9, Oct 16, Nov 27, Dec 4, Dec 11, Dec 18, Dec 25, 2027: Jan 1, Jan 8, Jan 15, Jan 22, Jan 29, Feb 5, Feb 12, Feb 19, Feb 26, Mar 5, Mar 12, Mar 19, Mar 26, More...
6 Night - Southeastern and Western Natural Selection Journey Roundtrip from Baltra Island & Santa Cruz Island
Starting in Baltra Island and Santa Cruz Island, San Cristobal Island, Espanola Island, Floreana Island, Isabela Island and Fernandina Island, Eden Islet and North Seymour Island, Baltra Airport
2026 Sails: Oct 2, Oct 16, Oct 30, Nov 13, Nov 27, Dec 11, Dec 25, 2027: Jan 8, Jan 22, Feb 5, Feb 19, Mar 5, Mar 19, Apr 2, Apr 16, Apr 30, May 14, May 28, Jun 11, Jun 25, Jul 9, Jul 23, Aug 6, Aug 20, More...
7 Night - Magic of Colombia
Starting in Barranquilla, Sitionuevo, Magangue, Mompox, Santa Barbara de Pinto, Calamar, Palenque, Cartagena CO
2026 Sails: Oct 3, Oct 31, Nov 14, Nov 28, Dec 12, Dec 26, More...
10 Night - Magic of Colombia with Panama Post Cruise
Starting in Barranquilla, Sitionuevo, Magangue, Mompox, Santa Barbara de Pinto, Calamar, Mahates, Cartagena CO, Colombia, Panama City
2026 Sails: Oct 3, Oct 31, Nov 14, Nov 28, Dec 12, Dec 26, More...
6 Night - Nature and Wildlife Expedition Cruise (Northern Route)
Starting in Quito Airport, Quito, Quito Airport, Seymour, Las Bachas, Santa Cruz Island, Buccaneer Cove, Puerto Egas, Rabida Island, Bartolome Island, Prince Philip Steps, Genovesa Island, Darwin Bay, Genovesa Island, Itabaca Channel, Seymour, Baltra Airport (Galapagos)
2026 Sails: Oct 3, Oct 17, Oct 31, Nov 14, Nov 28, Dec 12, Dec 26, More...
8 Night - Upper Amazon : a River Expedition
Starting in Lima, Peru, Lima / Iquitos / Nauta / Embark Ship, Pacaya-Samiria Reserve, Nauta / Disembark Ship / Iquitos / Lima
2026 Sails: Oct 3, Oct 17, Nov 14, Dec 5, Dec 12, Dec 19, 2027: Jan 9, Jan 16, Jan 23, Mar 13, Mar 20, Mar 27, Apr 10, Apr 17, Apr 24, Jun 12, Jun 19, Jun 26, Jul 17, Jul 24, Jul 31, Aug 7, Aug 14, Sep 4, More...
12 Night - Epic Galapagos Escape
Starting in Quito, Ecuador, Quito / Galapagos Islands / Embark Ship, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito, Quito
2026 Sails: Oct 3, Oct 31, Nov 14, Nov 28, Dec 26, 2027: Jan 9, Jan 23, Feb 6, Feb 20, Mar 6, Mar 20, More...
7 Night - Galapagos Escape : An Voyage
Starting in Quito, Ecuador, Quito / Galapagos Islands / Embark Ship, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito, Quito
2026 Sails: Oct 3, Oct 8, Oct 31, Nov 5, Nov 14, Nov 19, Nov 28, Dec 3, Dec 17, Dec 26, Dec 31, 2027: Jan 9, Jan 14, Jan 23, Jan 28, Feb 6, Feb 11, Feb 20, Feb 25, Mar 6, Mar 11, Mar 20, Mar 25, More...
32 Night - Across Oceanic Cultures : Fiji to the Chilean Coast
Starting in Lautoka, Fiji, Kadavu, Fiji, Vulaga, Fiji, Vavau, Tonga, Nukupule Island, Haapai Group, Tonga, Apia, Upolu, Samoa, Cross International Dateline, Aitutaki, Cook Islands, Raiatea, Society Islands, French Polynesia, Maroe Bay, Huahine Iti, French Polynesia, Papeete, French Polynesia, Anaa, French Polynesia, Avatoru, Rangiroa, French Polynesia, Adamstown, Pitcairn Island, Pitcairn, Ducie Island, Pitcairn, Easter Island, Chile, Juan Fernandez, San Antonio CL (Santiago), Chile
2026 Sails: Oct 4, More...
15 Night - Wonders of Colombia with in Medellin, in Cartagena Pre Cruise and in Panama City Post Cruise
Starting in Medellin, Cartagena CO, Colombia, Mahates, Calamar, Magangue, Mompox, Santa Barbara de Pinto, Sitionuevo, Barranquilla, Panama City
2026 Sails: Oct 5, Oct 19, Nov 16, Nov 30, 2027: May 17, More...
Cruises that visit South America
Cruises by region
See all South America River Cruises
Click on a cruise ship itinerary in South America (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just South America), please visit: Cruise Search or try our Virtual Cruise Advisor™.
Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : Uruguay
9 Night - Exploring GalapagosStarting in Quito, Ecuador, Quito / Galapagos Islands, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito, Quito
2026 Sails: Oct 2, Oct 9, Oct 16, Nov 27, Dec 4, Dec 11, Dec 18, Dec 25, 2027: Jan 1, Jan 8, Jan 15, Jan 22, Jan 29, Feb 5, Feb 12, Feb 19, Feb 26, Mar 5, Mar 12, Mar 19, Mar 26, More...
6 Night - Southeastern and Western Natural Selection Journey Roundtrip from Baltra Island & Santa Cruz IslandStarting in Baltra Island and Santa Cruz Island, San Cristobal Island, Espanola Island, Floreana Island, Isabela Island and Fernandina Island, Eden Islet and North Seymour Island, Baltra Airport
2026 Sails: Oct 2, Oct 16, Oct 30, Nov 13, Nov 27, Dec 11, Dec 25, 2027: Jan 8, Jan 22, Feb 5, Feb 19, Mar 5, Mar 19, Apr 2, Apr 16, Apr 30, May 14, May 28, Jun 11, Jun 25, Jul 9, Jul 23, Aug 6, Aug 20, More...
7 Night - Magic of ColombiaStarting in Barranquilla, Sitionuevo, Magangue, Mompox, Santa Barbara de Pinto, Calamar, Palenque, Cartagena CO
2026 Sails: Oct 3, Oct 31, Nov 14, Nov 28, Dec 12, Dec 26, More...
10 Night - Magic of Colombia with Panama Post CruiseStarting in Barranquilla, Sitionuevo, Magangue, Mompox, Santa Barbara de Pinto, Calamar, Mahates, Cartagena CO, Colombia, Panama City
2026 Sails: Oct 3, Oct 31, Nov 14, Nov 28, Dec 12, Dec 26, More...
6 Night - Nature and Wildlife Expedition Cruise (Northern Route)Starting in Quito Airport, Quito, Quito Airport, Seymour, Las Bachas, Santa Cruz Island, Buccaneer Cove, Puerto Egas, Rabida Island, Bartolome Island, Prince Philip Steps, Genovesa Island, Darwin Bay, Genovesa Island, Itabaca Channel, Seymour, Baltra Airport (Galapagos)
2026 Sails: Oct 3, Oct 17, Oct 31, Nov 14, Nov 28, Dec 12, Dec 26, More...
8 Night - Upper Amazon : a River ExpeditionStarting in Lima, Peru, Lima / Iquitos / Nauta / Embark Ship, Pacaya-Samiria Reserve, Nauta / Disembark Ship / Iquitos / Lima
2026 Sails: Oct 3, Oct 17, Nov 14, Dec 5, Dec 12, Dec 19, 2027: Jan 9, Jan 16, Jan 23, Mar 13, Mar 20, Mar 27, Apr 10, Apr 17, Apr 24, Jun 12, Jun 19, Jun 26, Jul 17, Jul 24, Jul 31, Aug 7, Aug 14, Sep 4, More...
12 Night - Epic Galapagos EscapeStarting in Quito, Ecuador, Quito / Galapagos Islands / Embark Ship, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito, Quito
2026 Sails: Oct 3, Oct 31, Nov 14, Nov 28, Dec 26, 2027: Jan 9, Jan 23, Feb 6, Feb 20, Mar 6, Mar 20, More...
7 Night - Galapagos Escape : An VoyageStarting in Quito, Ecuador, Quito / Galapagos Islands / Embark Ship, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito, Quito
2026 Sails: Oct 3, Oct 8, Oct 31, Nov 5, Nov 14, Nov 19, Nov 28, Dec 3, Dec 17, Dec 26, Dec 31, 2027: Jan 9, Jan 14, Jan 23, Jan 28, Feb 6, Feb 11, Feb 20, Feb 25, Mar 6, Mar 11, Mar 20, Mar 25, More...
32 Night - Across Oceanic Cultures : Fiji to the Chilean CoastStarting in Lautoka, Fiji, Kadavu, Fiji, Vulaga, Fiji, Vavau, Tonga, Nukupule Island, Haapai Group, Tonga, Apia, Upolu, Samoa, Cross International Dateline, Aitutaki, Cook Islands, Raiatea, Society Islands, French Polynesia, Maroe Bay, Huahine Iti, French Polynesia, Papeete, French Polynesia, Anaa, French Polynesia, Avatoru, Rangiroa, French Polynesia, Adamstown, Pitcairn Island, Pitcairn, Ducie Island, Pitcairn, Easter Island, Chile, Juan Fernandez, San Antonio CL (Santiago), Chile
2026 Sails: Oct 4, More...
15 Night - Wonders of Colombia with in Medellin, in Cartagena Pre Cruise and in Panama City Post CruiseStarting in Medellin, Cartagena CO, Colombia, Mahates, Calamar, Magangue, Mompox, Santa Barbara de Pinto, Sitionuevo, Barranquilla, Panama City
2026 Sails: Oct 5, Oct 19, Nov 16, Nov 30, 2027: May 17, More...