South America Cruises
Cruises that visit South America
Cruises by region
See all South America River Cruises
Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : Uruguay
9 Night - Exploring Peru : Machu Picchu and the Amazon
Starting in Lima, Peru, Lima / Cusco / Sacred Valley, Machu Picchu, Sacred Valley / Cusco, Cusco, Cusco / Lima / Iquitos / Nauta / Embark Ship, Pacaya-Samiria Reserve, Nauta / Disembark Ship / Iquitos / Lima
2026 Sails: Aug 20, Sep 10, Nov 5, Nov 26, Dec 3, More...
4 Night - Southeastern Galapagos Origin of Species Adventure Roundtrip from Baltra & South Plaza Islands
Starting in Baltra and South Plaza Islands, Santa Fe and San Cristobal, San Cristobal Island, Espanola Island, Santa Cruz Island and Baltra Island
2026 Sails: Aug 20, Sep 3, Sep 17, Oct 1, Oct 15, Oct 29, Nov 12, Nov 26, Dec 10, Dec 24, 2027: Jan 7, Jan 21, Feb 4, Feb 18, Mar 4, Mar 18, Apr 1, Apr 15, Apr 29, May 13, May 27, Jun 10, Jun 24, Jul 8, More...
15 Night - Wonders of Colombia with in Medellin, in Cartagena Pre Cruise and in Panama City Post Cruise
Starting in Medellin, Cartagena CO, Colombia, Mahates, Calamar, Magangue, Mompox, Santa Barbara de Pinto, Sitionuevo, Barranquilla, Panama City
2026 Sails: Aug 21, Sep 4, Oct 30, Nov 13, Nov 27, Dec 11, More...
12 Night - Wonders of Colombia with in Medellin, in Cartagena Pre Cruise
Starting in Medellin, Cartagena CO, Colombia, Mahates, Calamar, Magangue, Mompox, Santa Barbara de Pinto, Sitionuevo, Barranquilla
2026 Sails: Aug 21, Sep 4, Oct 30, Nov 13, Nov 27, Dec 11, More...
13 Night - Galapagos Islands - in Darwin's Footsteps Plus Machu Picchu
Starting in Lima / Jorge Chavez International Airport, Cusco, Quito, Mosquera, Quito, Capitania Seymour, Baltra, Punta Pitt, San Cristobal, Mosquera, Puerto Baquerizo Moreno, Plazas Sur, Punta Pitt, San Cristobal, Santa Fe, Puerto Ayora, Plazas Sur, Puerto Ayora, Punta Suarez, Bahia Gardner, Islote Eden, Seymour Norte, Capitania Seymour, Baltra, Quito
2026 Sails: Aug 21, Sep 4, Sep 18, Oct 2, Oct 16, Oct 30, Nov 13, Nov 27, Dec 11, More...
9 Night - Galapagos by Catamaran : An Intimate Voyage
Starting in Quito, Ecuador, Quito / Galapagos Islands, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito, Quito
2026 Sails: Aug 21, Aug 28, Sep 4, Sep 11, Sep 18, Sep 25, Oct 2, Oct 16, Oct 23, Oct 30, Nov 20, Dec 4, Dec 11, Dec 18, Dec 25, 2027: Jan 8, Jan 15, Jan 22, Jan 29, Feb 5, Feb 12, Feb 19, Mar 5, Mar 12, More...
15 Night - Galapagos by Catamaran, Machu Picchu and Peru's Land of the Inca
Starting in Quito, Ecuador, Quito / Galapagos Islands / Embark Ship, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito / Lima, Peru, Lima, Lima / Cusco / Sacred Valley, Sacred Valley, Sacred Valley / Machu Picchu, Machu Picchu / Cusco, Cusco, Cusco / Lima
2026 Sails: Aug 21, Aug 28, Sep 4, Sep 11, Sep 18, Sep 25, Oct 2, Oct 16, Oct 23, Oct 30, Nov 20, Dec 4, Dec 11, Dec 18, Dec 25, 2027: Jan 8, Jan 15, Jan 22, Jan 29, Feb 5, Feb 12, Feb 19, Mar 5, Mar 12, More...
15 Night - Exploring Galapagos, Machu Picchu and Peru's Land of the Inca
Starting in Quito, Ecuador, Quito / Galapagos Islands / Embark Ship, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito / Lima, Peru, Lima, Lima / Cusco / Sacred Valley, Sacred Valley, Sacred Valley / Machu Picchu, Machu Picchu / Cusco, Cusco, Cusco / Lima
2026 Sails: Aug 21, Sep 25, Oct 2, Oct 9, Oct 16, Oct 23, Oct 30, Nov 6, Nov 13, Nov 20, Nov 27, Dec 4, Dec 11, Dec 18, Dec 25, 2027: Jan 1, Jan 8, Jan 15, Jan 22, Jan 29, Feb 5, Feb 12, Feb 19, Feb 26, More...
9 Night - Exploring Galapagos
Starting in Quito, Ecuador, Quito / Galapagos Islands, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito, Quito
2026 Sails: Aug 21, Sep 25, Oct 2, Oct 9, Oct 16, Oct 23, Oct 30, Nov 6, Nov 13, Nov 20, Nov 27, Dec 4, Dec 11, Dec 18, Dec 25, 2027: Jan 1, Jan 8, Jan 15, Jan 22, Jan 29, Feb 5, Feb 12, Feb 19, Feb 26, More...
15 Night - Exploring Galapagos, Machu Picchu and Peru's Land of the Inca
Starting in Quito, Ecuador, Quito / Galapagos Islands / Embark Ship, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito / Lima, Peru, Lima, Lima / Cusco / Sacred Valley, Sacred Valley, Sacred Valley / Machu Picchu, Machu Picchu / Cusco, Cusco, Cusco / Lima
2026 Sails: Aug 21, Aug 28, Sep 4, Sep 11, Sep 18, Sep 25, Oct 2, Oct 9, Oct 16, Nov 27, Dec 4, Dec 11, Dec 18, Dec 25, 2027: Jan 1, Jan 8, Jan 15, Jan 22, Jan 29, Feb 5, Feb 12, Feb 19, Feb 26, Mar 5, More...
Cruises that visit South America
Cruises by region
See all South America River Cruises
Click on a cruise ship itinerary in South America (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just South America), please visit: Cruise Search or try our Virtual Cruise Advisor™.
Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : Uruguay
9 Night - Exploring Peru : Machu Picchu and the AmazonStarting in Lima, Peru, Lima / Cusco / Sacred Valley, Machu Picchu, Sacred Valley / Cusco, Cusco, Cusco / Lima / Iquitos / Nauta / Embark Ship, Pacaya-Samiria Reserve, Nauta / Disembark Ship / Iquitos / Lima
2026 Sails: Aug 20, Sep 10, Nov 5, Nov 26, Dec 3, More...
4 Night - Southeastern Galapagos Origin of Species Adventure Roundtrip from Baltra & South Plaza IslandsStarting in Baltra and South Plaza Islands, Santa Fe and San Cristobal, San Cristobal Island, Espanola Island, Santa Cruz Island and Baltra Island
2026 Sails: Aug 20, Sep 3, Sep 17, Oct 1, Oct 15, Oct 29, Nov 12, Nov 26, Dec 10, Dec 24, 2027: Jan 7, Jan 21, Feb 4, Feb 18, Mar 4, Mar 18, Apr 1, Apr 15, Apr 29, May 13, May 27, Jun 10, Jun 24, Jul 8, More...
15 Night - Wonders of Colombia with in Medellin, in Cartagena Pre Cruise and in Panama City Post CruiseStarting in Medellin, Cartagena CO, Colombia, Mahates, Calamar, Magangue, Mompox, Santa Barbara de Pinto, Sitionuevo, Barranquilla, Panama City
2026 Sails: Aug 21, Sep 4, Oct 30, Nov 13, Nov 27, Dec 11, More...
12 Night - Wonders of Colombia with in Medellin, in Cartagena Pre CruiseStarting in Medellin, Cartagena CO, Colombia, Mahates, Calamar, Magangue, Mompox, Santa Barbara de Pinto, Sitionuevo, Barranquilla
2026 Sails: Aug 21, Sep 4, Oct 30, Nov 13, Nov 27, Dec 11, More...
13 Night - Galapagos Islands - in Darwin's Footsteps Plus Machu PicchuStarting in Lima / Jorge Chavez International Airport, Cusco, Quito, Mosquera, Quito, Capitania Seymour, Baltra, Punta Pitt, San Cristobal, Mosquera, Puerto Baquerizo Moreno, Plazas Sur, Punta Pitt, San Cristobal, Santa Fe, Puerto Ayora, Plazas Sur, Puerto Ayora, Punta Suarez, Bahia Gardner, Islote Eden, Seymour Norte, Capitania Seymour, Baltra, Quito
2026 Sails: Aug 21, Sep 4, Sep 18, Oct 2, Oct 16, Oct 30, Nov 13, Nov 27, Dec 11, More...
9 Night - Galapagos by Catamaran : An Intimate VoyageStarting in Quito, Ecuador, Quito / Galapagos Islands, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito, Quito
2026 Sails: Aug 21, Aug 28, Sep 4, Sep 11, Sep 18, Sep 25, Oct 2, Oct 16, Oct 23, Oct 30, Nov 20, Dec 4, Dec 11, Dec 18, Dec 25, 2027: Jan 8, Jan 15, Jan 22, Jan 29, Feb 5, Feb 12, Feb 19, Mar 5, Mar 12, More...
15 Night - Galapagos by Catamaran, Machu Picchu and Peru's Land of the IncaStarting in Quito, Ecuador, Quito / Galapagos Islands / Embark Ship, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito / Lima, Peru, Lima, Lima / Cusco / Sacred Valley, Sacred Valley, Sacred Valley / Machu Picchu, Machu Picchu / Cusco, Cusco, Cusco / Lima
2026 Sails: Aug 21, Aug 28, Sep 4, Sep 11, Sep 18, Sep 25, Oct 2, Oct 16, Oct 23, Oct 30, Nov 20, Dec 4, Dec 11, Dec 18, Dec 25, 2027: Jan 8, Jan 15, Jan 22, Jan 29, Feb 5, Feb 12, Feb 19, Mar 5, Mar 12, More...
15 Night - Exploring Galapagos, Machu Picchu and Peru's Land of the IncaStarting in Quito, Ecuador, Quito / Galapagos Islands / Embark Ship, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito / Lima, Peru, Lima, Lima / Cusco / Sacred Valley, Sacred Valley, Sacred Valley / Machu Picchu, Machu Picchu / Cusco, Cusco, Cusco / Lima
2026 Sails: Aug 21, Sep 25, Oct 2, Oct 9, Oct 16, Oct 23, Oct 30, Nov 6, Nov 13, Nov 20, Nov 27, Dec 4, Dec 11, Dec 18, Dec 25, 2027: Jan 1, Jan 8, Jan 15, Jan 22, Jan 29, Feb 5, Feb 12, Feb 19, Feb 26, More...
9 Night - Exploring GalapagosStarting in Quito, Ecuador, Quito / Galapagos Islands, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito, Quito
2026 Sails: Aug 21, Sep 25, Oct 2, Oct 9, Oct 16, Oct 23, Oct 30, Nov 6, Nov 13, Nov 20, Nov 27, Dec 4, Dec 11, Dec 18, Dec 25, 2027: Jan 1, Jan 8, Jan 15, Jan 22, Jan 29, Feb 5, Feb 12, Feb 19, Feb 26, More...
15 Night - Exploring Galapagos, Machu Picchu and Peru's Land of the IncaStarting in Quito, Ecuador, Quito / Galapagos Islands / Embark Ship, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito / Lima, Peru, Lima, Lima / Cusco / Sacred Valley, Sacred Valley, Sacred Valley / Machu Picchu, Machu Picchu / Cusco, Cusco, Cusco / Lima
2026 Sails: Aug 21, Aug 28, Sep 4, Sep 11, Sep 18, Sep 25, Oct 2, Oct 9, Oct 16, Nov 27, Dec 4, Dec 11, Dec 18, Dec 25, 2027: Jan 1, Jan 8, Jan 15, Jan 22, Jan 29, Feb 5, Feb 12, Feb 19, Feb 26, Mar 5, More...