South America Cruises
Cruises that visit South America
Cruises by region
See all South America River Cruises
Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : South Georgia / South Sandwich Islands : Uruguay
11 Night - Galapagos Islands - Iconic Wildlife & Sublime Scenery Plus Machu Picchu
Starting in Lima Airport, Lima, Lima Airport, Cusco Airport, Quito Airport, Quito, Quito Airport, Seymour, Dragon Hill, Punta Vicente Roca, Fernandina, Puerto Ayora, Isla Santa Cruz, Post Office Bay, Champion Islet, Punta Cormorant, Seymour, Baltra Airport (Galapagos)
2026 Sails: Nov 19, Dec 3, Dec 17, More...
7 Night - Galapagos Escape : An Voyage
Starting in Quito, Ecuador, Quito / Galapagos Islands / Embark Ship, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito, Quito
2026 Sails: Nov 19, Nov 28, Dec 3, Dec 17, Dec 26, Dec 31, 2027: Jan 9, Jan 14, Jan 23, Jan 28, Feb 6, Feb 11, Feb 20, Feb 25, Mar 6, Mar 11, Mar 20, Mar 25, More...
11 Night - Peru and Galapagos Escape
Starting in Lima, Peru, Lima / Cusco / Sacred Valley, Machu Picchu, Sacred Valley / Cusco, Cusco, Cusco / Lima / Guayaquil, Ecuador, Guayaquil / Baltra / Embark Ship, Baltra / Disembark Ship / Quito, Quito
2026 Sails: Nov 19, Dec 3, Dec 17, Dec 31, 2027: Jan 14, Jan 28, Feb 11, Feb 25, Mar 11, More...
8 Night - Antarctica Direct : Fly the Drake Passage
Starting in Puerto Natales, Chile, Puerto Natales / King George Island, Antarctica / Embark Ship, Antarctica, King George Island / Disembark Ship / Puerto Natales, Puerto Natales
2026 Sails: Nov 19, Nov 25, Dec 27, 2027: Jan 2, Jan 8, Jan 19, Jan 25, Jan 31, Feb 6, Nov 28, Dec 4, Dec 21, Dec 27, 2028: Jan 2, Jan 25, Jan 31, Feb 23, Feb 29, Nov 23, Nov 29, Dec 21, Dec 27, 2029: Jan 18, Jan 24, More...
4 Night - Northwestern Islands of Fire Adventure Roundtrip from Baltra Island & Santa Cruz Island
Starting in Baltra Island and Santa Cruz Island, Bartolome Island and Santiago Island, Santa Cruz Island and Santiago Island, Isabela Island and Fernandina Island, Baltra Island
2026 Sails: Nov 19, Dec 3, Dec 17, Dec 31, 2027: Jan 14, Jan 28, Feb 11, Feb 25, Mar 11, Mar 25, Apr 8, Apr 22, May 6, May 20, Jun 3, Jun 17, Jul 1, Jul 15, Jul 29, Aug 12, Aug 26, Sep 9, Sep 23, Oct 7, More...
18 Night - Brazilian Adventure
Starting in Fort Lauderdale, Florida, St Maarten, St Lucia, Barbados, Fortaleza, Brazil, Rio De Janeiro, Brazil, Montevideo, Uruguay, Buenos Aires, Argentina
2026 Sails: Nov 19, More...
33 Night - Brazilian & Cape Horn Grand Adventure
Starting in Fort Lauderdale, Florida, St Maarten, St Lucia, Barbados, Fortaleza, Brazil, Rio De Janeiro, Brazil, Montevideo, Uruguay, Buenos Aires, Argentina, Montevideo, Uruguay, Puerto Madryn, Argentina, Port Stanley, Falkland Islands, Cape Horn (Scenic Cruising), Ushuaia (Tierra del Fuego), Argentina, Beagle Channel Fjords and Glacier Alley, Chile, Punta Arenas, Chile, Puerto Montt, Chile, Santiago (Valparaiso), Chile
2026 Sails: Nov 19, More...
6 Night - Galapagos from Quito to Guayaquil
Starting in Quito Airport, Seymour, Mosquera, Puerto Baquerizo Moreno, Punta Pitt, San Cristobal Island, Santa Fe, South Plaza Island, Charles Darwin Research Station, Santa Cruz Island, Punta Suarez, Espanola Island, Gardner Bay, Espanola Island, Eden Islet, San Cristobal Island, Seymour Norte, Seymour, Baltra Airport (Galapagos)
2026 Sails: Nov 20, Dec 4, Dec 18, More...
9 Night - Galapagos by Catamaran : An Intimate Voyage
Starting in Quito, Ecuador, Quito / Galapagos Islands, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito, Quito
2026 Sails: Nov 20, Dec 4, Dec 11, Dec 18, Dec 25, 2027: Jan 8, Jan 15, Jan 22, Jan 29, Feb 5, Feb 12, Feb 19, Mar 5, Mar 12, Mar 19, Mar 26, Apr 2, Apr 9, Apr 16, Apr 23, May 7, May 14, May 21, May 28, More...
15 Night - Galapagos by Catamaran, Machu Picchu and Peru's Land of the Inca
Starting in Quito, Ecuador, Quito / Galapagos Islands / Embark Ship, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito / Lima, Peru, Lima, Lima / Cusco / Sacred Valley, Sacred Valley, Sacred Valley / Machu Picchu, Machu Picchu / Cusco, Cusco, Cusco / Lima
2026 Sails: Nov 20, Dec 4, Dec 11, Dec 18, Dec 25, 2027: Jan 8, Jan 15, Jan 22, Jan 29, Feb 5, Feb 12, Feb 19, Mar 5, Mar 12, Mar 19, Mar 26, Apr 2, Apr 9, Apr 16, Apr 23, May 7, May 14, May 21, May 28, More...
Cruises that visit South America
Cruises by region
See all South America River Cruises
Click on a cruise ship itinerary in South America (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just South America), please visit: Cruise Search or try our Virtual Cruise Advisor™.
Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : South Georgia / South Sandwich Islands : Uruguay
11 Night - Galapagos Islands - Iconic Wildlife & Sublime Scenery Plus Machu PicchuStarting in Lima Airport, Lima, Lima Airport, Cusco Airport, Quito Airport, Quito, Quito Airport, Seymour, Dragon Hill, Punta Vicente Roca, Fernandina, Puerto Ayora, Isla Santa Cruz, Post Office Bay, Champion Islet, Punta Cormorant, Seymour, Baltra Airport (Galapagos)
2026 Sails: Nov 19, Dec 3, Dec 17, More...
7 Night - Galapagos Escape : An VoyageStarting in Quito, Ecuador, Quito / Galapagos Islands / Embark Ship, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito, Quito
2026 Sails: Nov 19, Nov 28, Dec 3, Dec 17, Dec 26, Dec 31, 2027: Jan 9, Jan 14, Jan 23, Jan 28, Feb 6, Feb 11, Feb 20, Feb 25, Mar 6, Mar 11, Mar 20, Mar 25, More...
11 Night - Peru and Galapagos EscapeStarting in Lima, Peru, Lima / Cusco / Sacred Valley, Machu Picchu, Sacred Valley / Cusco, Cusco, Cusco / Lima / Guayaquil, Ecuador, Guayaquil / Baltra / Embark Ship, Baltra / Disembark Ship / Quito, Quito
2026 Sails: Nov 19, Dec 3, Dec 17, Dec 31, 2027: Jan 14, Jan 28, Feb 11, Feb 25, Mar 11, More...
8 Night - Antarctica Direct : Fly the Drake PassageStarting in Puerto Natales, Chile, Puerto Natales / King George Island, Antarctica / Embark Ship, Antarctica, King George Island / Disembark Ship / Puerto Natales, Puerto Natales
2026 Sails: Nov 19, Nov 25, Dec 27, 2027: Jan 2, Jan 8, Jan 19, Jan 25, Jan 31, Feb 6, Nov 28, Dec 4, Dec 21, Dec 27, 2028: Jan 2, Jan 25, Jan 31, Feb 23, Feb 29, Nov 23, Nov 29, Dec 21, Dec 27, 2029: Jan 18, Jan 24, More...
4 Night - Northwestern Islands of Fire Adventure Roundtrip from Baltra Island & Santa Cruz IslandStarting in Baltra Island and Santa Cruz Island, Bartolome Island and Santiago Island, Santa Cruz Island and Santiago Island, Isabela Island and Fernandina Island, Baltra Island
2026 Sails: Nov 19, Dec 3, Dec 17, Dec 31, 2027: Jan 14, Jan 28, Feb 11, Feb 25, Mar 11, Mar 25, Apr 8, Apr 22, May 6, May 20, Jun 3, Jun 17, Jul 1, Jul 15, Jul 29, Aug 12, Aug 26, Sep 9, Sep 23, Oct 7, More...
18 Night - Brazilian AdventureStarting in Fort Lauderdale, Florida, St Maarten, St Lucia, Barbados, Fortaleza, Brazil, Rio De Janeiro, Brazil, Montevideo, Uruguay, Buenos Aires, Argentina
2026 Sails: Nov 19, More...
33 Night - Brazilian & Cape Horn Grand AdventureStarting in Fort Lauderdale, Florida, St Maarten, St Lucia, Barbados, Fortaleza, Brazil, Rio De Janeiro, Brazil, Montevideo, Uruguay, Buenos Aires, Argentina, Montevideo, Uruguay, Puerto Madryn, Argentina, Port Stanley, Falkland Islands, Cape Horn (Scenic Cruising), Ushuaia (Tierra del Fuego), Argentina, Beagle Channel Fjords and Glacier Alley, Chile, Punta Arenas, Chile, Puerto Montt, Chile, Santiago (Valparaiso), Chile
2026 Sails: Nov 19, More...
6 Night - Galapagos from Quito to GuayaquilStarting in Quito Airport, Seymour, Mosquera, Puerto Baquerizo Moreno, Punta Pitt, San Cristobal Island, Santa Fe, South Plaza Island, Charles Darwin Research Station, Santa Cruz Island, Punta Suarez, Espanola Island, Gardner Bay, Espanola Island, Eden Islet, San Cristobal Island, Seymour Norte, Seymour, Baltra Airport (Galapagos)
2026 Sails: Nov 20, Dec 4, Dec 18, More...
9 Night - Galapagos by Catamaran : An Intimate VoyageStarting in Quito, Ecuador, Quito / Galapagos Islands, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito, Quito
2026 Sails: Nov 20, Dec 4, Dec 11, Dec 18, Dec 25, 2027: Jan 8, Jan 15, Jan 22, Jan 29, Feb 5, Feb 12, Feb 19, Mar 5, Mar 12, Mar 19, Mar 26, Apr 2, Apr 9, Apr 16, Apr 23, May 7, May 14, May 21, May 28, More...
15 Night - Galapagos by Catamaran, Machu Picchu and Peru's Land of the IncaStarting in Quito, Ecuador, Quito / Galapagos Islands / Embark Ship, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito / Lima, Peru, Lima, Lima / Cusco / Sacred Valley, Sacred Valley, Sacred Valley / Machu Picchu, Machu Picchu / Cusco, Cusco, Cusco / Lima
2026 Sails: Nov 20, Dec 4, Dec 11, Dec 18, Dec 25, 2027: Jan 8, Jan 15, Jan 22, Jan 29, Feb 5, Feb 12, Feb 19, Mar 5, Mar 12, Mar 19, Mar 26, Apr 2, Apr 9, Apr 16, Apr 23, May 7, May 14, May 21, May 28, More...