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South America Cruises

Cruises that visit South America

Cruises by region

See all South America River Cruises

Click on a cruise ship itinerary in South America (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just South America), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : Uruguay



MSC Cruises, MSC Poesia
MSC Poesia21 Night - Caribbean and Antilles
Starting in Miami, Florida, Ocho Rios, Jamaica, Cartagena CO, Colon, Panama, Puerto Limon, Costa Rica, Isla De Roatan, Honduras, Belize City, Belize, Miami, Florida, Charlotte Amalie (St Thomas) Virgin Islands, Basseterre, St Kitts and Nevis, Philipsburg, St Maarten, St Johns AG, Antigua, San Juan, Puerto Rico, Puerto Plata, Dominican Republic, Miami, Florida
2026 Sails: Nov 1, More...
Costa Cruise Lines, Costa Diadema
Costa Diadema23 Night - Transatlantic from Savona to Itajai
Starting in Savona, Barcelona, Malaga, Cadiz, Lisbon, Las Palmas (Gran Canaria), Santa Cruz de Tenerife, Mindelo (Sao Vicente), Maceio, Salvador Bahia, Rio De Janeiro, Santos (Sao Paulo), Itajai
2026 Sails: Nov 2, More...
Costa Cruise Lines, Costa Diadema
Costa Diadema21 Night - Transatlantic from Savona
Starting in Savona, Barcelona, Malaga, Cadiz, Lisbon, Las Palmas (Gran Canaria), Santa Cruz de Tenerife, Mindelo (Sao Vicente), Maceio, Salvador Bahia, Rio De Janeiro, Santos (Sao Paulo)
2026 Sails: Nov 2, More...
Costa Cruise Lines, Costa Diadema
Costa Diadema20 Night - Transatlantic from Savona
Starting in Savona, Barcelona, Malaga, Cadiz, Lisbon, Las Palmas (Gran Canaria), Santa Cruz de Tenerife, Mindelo (Sao Vicente), Maceio, Salvador Bahia, Rio De Janeiro
2026 Sails: Nov 2, More...
MSC Cruises, MSC Divina
MSC Divina14 Night - Msc Grand Voyages
Starting in Tarragona, Spain, Santa Cruz de Tenerife, Salvador, Brazil, Rio De Janeiro, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Nov 2, More...
MSC Cruises, MSC Divina
MSC Divina13 Night - Msc Grand Voyages
Starting in Tarragona, Spain, Santa Cruz de Tenerife, Salvador, Brazil, Rio De Janeiro, Brazil
2026 Sails: Nov 2, More...
Oceania Cruises, Oceania Insignia
Oceania Insignia47 Night - Footsteps of Columbus
Starting in Barcelona, Palma De Mallorca, Alicante, Cartagena ES, Malaga, Seville (Cadiz), Portimao, Lisbon, Arrecife (Lanzarote), Las Palmas De Gran Canaria, Santa Cruz de La Palma, San Juan, Nassau, Miami, Tortola, St Johns AG, Castries, Scarborough, Cruising the Amazon River, Santarem (Amazon River), Boca Da Valeria (Amazon River), Manaus (Amazon River), Parintins (Amazon River), Alter Do Chao (Amazon River), Cruising the Amazon River, Bridgetown, Roseau, Philipsburg, San Juan, Nassau, Miami
2026 Sails: Nov 2, More...
Costa Cruise Lines, Costa Diadema
Costa Diadema22 Night - Transatlantic from Barcelona to Itajai
Starting in Barcelona, Malaga, Cadiz, Lisbon, Las Palmas (Gran Canaria), Santa Cruz de Tenerife, Mindelo (Sao Vicente), Maceio, Salvador Bahia, Rio De Janeiro, Santos (Sao Paulo), Itajai
2026 Sails: Nov 3, More...
Costa Cruise Lines, Costa Diadema
Costa Diadema19 Night - Transatlantic from Barcelona
Starting in Barcelona, Malaga, Cadiz, Lisbon, Las Palmas (Gran Canaria), Santa Cruz de Tenerife, Mindelo (Sao Vicente), Maceio, Salvador Bahia, Rio De Janeiro
2026 Sails: Nov 3, More...
Costa Cruise Lines, Costa Diadema
Costa Diadema20 Night - Transatlantic from Barcelona
Starting in Barcelona, Malaga, Cadiz, Lisbon, Las Palmas (Gran Canaria), Santa Cruz de Tenerife, Mindelo (Sao Vicente), Maceio, Salvador Bahia, Rio De Janeiro, Santos (Sao Paulo)
2026 Sails: Nov 3, More...

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South America Cruises