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South America Cruises

Cruises that visit South America

Cruises by region

See all South America River Cruises

Click on a cruise ship itinerary in South America (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just South America), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : South Georgia / South Sandwich Islands : Uruguay



MSC Divina3 Night - South America
Starting in Santos (Sao Paulo), Brazil, Buzios, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Dec 15, Dec 26, 2027: Jan 2, Jan 23, Feb 9, Mar 11, 2028: Feb 29, Mar 13, Mar 16, More...
Viking Sea21 Night - From the Caribbean to the Amazon
Starting in San Juan, Sail the Caribbean Sea, Bridgetown, Sail the Caribbean Sea, French Guiana (Iles Du Salut), Sail the Atlantic Ocean, Sail the Amazon River, Santarem, Parintins, Manaus, Sail the Amazon River, Belem, Sail the Atlantic Ocean, Scarborough, Castries, St Johns AG, Antigua, St Thomas (Charlotte Amalie), San Juan
2026 Sails: Dec 15, More...
Caribbean Princess12 Night - Panama Canal with Costa Rica & Caribbean
Starting in Fort Lauderdale, Florida, Aruba, Cartagena CO, Panama Canal Partial Transit New Locks, Colon, Panama, Limon, Costa Rica, Grand Cayman, Cayman Islands, Fort Lauderdale, Florida
2026 Sails: Dec 17, Dec 29, 2027: Feb 3, Feb 15, More...
Ultramarine Tours11 Night - Antarctic Explorer : Discovering the 7Th Continent
Starting in Arrive in Buenos Aires, Argentina, Fly to Ushuaia and Embark, Crossing the Drake Passage, South Shetland Islands and Antarctic Peninsula, Crossing the Drake Passage, Disembark in Ushuaia and Fly to Buenos Aires
2026 Sails: Dec 17, Dec 27, 2027: Jan 6, Feb 28, Mar 10, Nov 6, Dec 8, Dec 18, Dec 28, 2028: Jan 7, Feb 29, Mar 10, More...
MSC Divina3 Night - South America
Starting in Santos (Sao Paulo), Brazil, Angra Dos Reis, Brazil, Buzios, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Dec 18, More...
World Voyager Quark Tours10 Night - Antarctic Explorer : Discovering the 7Th Continent
Starting in Arrive in Buenos Aires, Argentina, Fly to Ushuaia and Embark, Crossing the Drake Passage, South Shetland Islands and Antarctic Peninsula, Crossing the Drake Passage, Disembark in Ushuaia
2026 Sails: Dec 18, 2027: Jan 5, Jan 26, Nov 5, Nov 23, 2028: Jan 6, Jan 15, More...
Costa Diadema7 Night - South America Roundtrip from Itajai
Starting in Itajai, Brazil, Santos / Sao Paulo, Buenos Aires, Argentina, Montevideo, Uruguay, Itajai, Brazil
2026 Sails: Dec 19, Dec 26, 2027: Jan 2, Jan 9, Jan 16, Jan 23, Feb 6, Feb 20, Feb 27, More...
Oosterdam22 Night - South America & Antarctica Holiday
Starting in Buenos Aires, Argentina, Montevideo, Uruguay, Punta Del Este, Uruguay, Puerto Madryn, Argentina, Port Stanley, Falkland Islands, Antarctic, Drake Passage and Cape Horn, Ushuaia, Argentina, Daylight cruising Glacier Alley, Beagle Channel, Punta Arenas, Chile, Strait of Magellan, Scenic cruising Sarmiento Channel, Scenic cruising Amalia or Brujo Glacier, Cruising Chilean Fjords, Puerto Chacabuco, Chile, Puerto Montt, Chile, Valparaiso (Santiago), Chile
2026 Sails: Dec 19, More...
Zaandam15 Night - Panama Canal Holiday
Starting in San Diego, California, Cabo San Lucas, Mexico, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Quetzal, Guatemala, Puntarenas (Puerto Caldera), Costa Rica, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, Fort Lauderdale, Florida
2026 Sails: Dec 19, More...
National Geographic Explorer Tours9 Night - Antarctica Direct : Sail and Fly the Drake Passage
Starting in Puerto Natales, Chile, Puerto Natales / King George Island, Antarctica / Embark Ship, Antarctica, At Sea / Crossing the Drake Passage, Ushuaia, Argentina / Disembark Ship, Ushuaia
2026 Sails: Dec 19, 2027: Jan 7, Jan 26, Dec 1, Dec 20, 2028: Jan 8, Jan 27, Feb 15, Mar 5, More...


South America Cruises