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Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Cartagena ES : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Departing from
Spain
Cruise Specials

EXPLORA I14 Night - An Extended Journey of Sunlit Discovery & Timeless Wonder
Starting in Barcelona, Ibiza, Tunis / La Goulette, La Valletta, Giardini Naxos, Sorrento, Civitavecchia (Rome), La Spezia, Monte Carlo, Saint-Tropez, Mahon (Menorca), Valencia, Barcelona
2026 Sails: Sep 28, More...
Regent Seven Seas, Seven Seas Voyager
Seven Seas Voyager12 Night - Mediterranean Nights
Starting in Barcelona, Toulon, La Spezia (Cinque Terre), Cruising the Tyrrhenian Sea, Valletta, Cruising the Tyrrhenian Sea, Sorrento / Capri, Rome (Civitavecchia)
2026 Sails: Sep 28, More...
Silversea, Silver Ray
Silver Ray10 Night - Barcelona to Monte Carlo
Starting in Barcelona, Malaga (Costa del Sol), Cartagena ES, Spain, Valencia, Palma De Mallorca, Palamos, Marseille, Saint Tropez, Monte Carlo
2026 Sails: Sep 28, More...
Silversea, Silver Ray
Silver Ray20 Night - Southern Europe from Barcelona to Rome (Civitavecchia)
Starting in Barcelona, Malaga, Cartagena ES, Valencia, Palma De Mallorca, Palamos, Marseille, Saint Tropez, Monte Carlo, Toulon, Ajaccio, Porto Santo Stefano, Portoferraio, Livorno, Portofino, Trapani, Naples, Civitavecchia
2026 Sails: Sep 28, More...
Silversea, Silver Spirit
Silver Spirit10 Night - Barcelona to Civitavecchia
Starting in Barcelona, Palamos, Palma De Mallorca, Sete, Marseille, Monte Carlo, Livorno (Tuscany), Porto Santo Stefano, Civitavecchia (Rome)
2026 Sails: Sep 28, More...
Costa Cruise Lines, Costa Pacifica
Costa Pacifica7 Night - Western Mediterranean from Palma De Mallorca
Starting in Palma De Mallorca, Valencia, Olbia, Civitavecchia (Rome), Savona, Marseille, Barcelona
2026 Sails: Sep 29, More...
Costa Cruise Lines, Costa Pacifica
Costa Pacifica6 Night - Western Mediterranean from Valencia
Starting in Valencia, Olbia, Civitavecchia (Rome), Savona, Marseille, Barcelona
2026 Sails: Sep 30, More...
Oceania Cruises, Oceania Sirena
Oceania Sirena12 Night - French & Italian Treasures
Starting in Barcelona, Palamos, Toulon, Saint-Tropez, Cinque Terre (La Spezia), Ajaccio (Corsica), Cagliari (Sardinia), Trapani (Sicily), Valletta, Messina (Sicily), Sorrento / Capri, Porto Ercole, Rome (Civitavecchia)
2026 Sails: Sep 30, More...
Celebrity Cruises, Celebrity Equinox
Celebrity Equinox9 Night - Spain, Portugal & Morocco
Starting in Barcelona, Spain, Lisbon, Portugal, Porto (Leixoes), Portugal, Seville (Cadiz), Spain, Tangier, Morocco, Barcelona, Spain
2026 Sails: Oct 1, More...
Crystal Cruises, Crystal Serenity
Crystal Serenity10 Night - Europe & Mediterranean
Starting in Barcelona, Palma De Mallorca, Alicante, Cartagena ES, Spain, Malaga (Costa del Sol), Gibraltar, Casablanca, Morocco, Tangier, Cadiz, Lisbon
2026 Sails: Oct 1, More...

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Spain Cruise Departures