Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Oceania Cruises, Oceania Sirena

Deal link -> Special

12 Night - Canaries, Morocco & More
Starting in Barcelona, Alicante, Almeria, Gibraltar, Casablanca, Agadir, Arrecife (Lanzarote), Las Palmas De Gran Canaria, Santa Cruz de Tenerife, Santa Cruz de La Palma, Funchal (Madeira), Lisbon
2026 Sails: Dec 9, More...

Oceania Cruises, Oceania Sirena

26 Night - Ramblas to Renaissance
Starting in Barcelona, Alicante, Almeria, Gibraltar, Casablanca, Agadir, Arrecife (Lanzarote), Las Palmas De Gran Canaria, Santa Cruz de Tenerife, Santa Cruz de La Palma, Funchal (Madeira), Lisbon, Portimao, Seville (Cadiz), Malaga, Palma De Mallorca, Palamos, Toulon, Cinque Terre (La Spezia), Ajaccio (Corsica), Barcelona, Rome (Civitavecchia)
2026 Sails: Dec 9, More...

Viking Ocean, Viking Sky

13 Night - Atlantic Ocean Passage
Starting in Barcelona, Sail the Mediterranean Sea, Sail the Atlantic Ocean, Madeira (Funchal), Sail the Atlantic Ocean, Philipsburg, Sail the Caribbean Sea, Fort Lauderdale, Florida
2026 Sails: Dec 9, More...

Costa Cruise Lines, Costa Fascinosa

10 Night - Transatlantic from Las Palmas (Gran Canaria)
Starting in Las Palmas (Gran Canaria), Pointe-a-Pitre, Philipsburg, La Romana
2026 Sails: Dec 10, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean from Las Palmas
Starting in Las Palmas (Gran Canaria), Agadir, Santa Cruz de Tenerife, Las Palmas (Gran Canaria)
2026 Sails: Dec 10, More...

MSC Cruises, MSC World Asia

3 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy
2026 Sails: Dec 11, More...

Viking Ocean, Viking Saturn

15 Night - Malta, Morocco & the Mediterranean
Starting in Barcelona, Marseille, Corsica (Ajaccio), Rome (Civitavecchia), Sail the Mediterranean Sea, Valletta, Tunis (La Goulette), Sail the Mediterranean Sea, Algiers, Sail the Strait of Gibraltar, Casablanca, Seville (Cadiz), Sail the Alboran Sea, Barcelona
2026 Sails: Dec 12, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean from S. Cruz De Tenerife
Starting in Santa Cruz de Tenerife, Las Palmas (Gran Canaria), Funchal (Madeira), Santa Cruz de Tenerife
2026 Sails: Dec 13, More...

MSC Cruises, MSC Fantasia

7 Night - Canary Islands and Madeira
Starting in Santa Cruz de Tenerife, Puerto Del Rosario / Fuerteventura, Spain, Funchal (Madeira Islands), Portugal, Arrecife De Lanzarote (Canary Islands), Spain, Las Palmas de Gran Canaria (Canary Islands), Spain, Santa Cruz de La Palma, Santa Cruz de Tenerife
2026 Sails: Dec 13, Dec 20, 2027: Jan 3, Jan 10, Jan 17, Jan 24, Jan 31, Feb 7, Feb 21, Feb 28, Mar 7, Mar 14, Mar 21, Mar 28, Nov 21, Nov 28, Dec 5, Dec 12, Dec 19, Dec 26, 2028: Jan 2, Jan 9, Jan 16, Jan 23, More...

Regent Seven Seas, Seven Seas Prestige

14 Night - Felices Fiestas
Starting in Barcelona, Cruising the Mediterranean Sea, Malaga, Cruising the Atlantic Ocean, Funchal (Madeira), Cruising the Atlantic Ocean, San Juan, Cruising the Atlantic Ocean, Miami
2026 Sails: Dec 13, More...

<= Back

More =>