Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Disney Cruise Line, Disney Dream

9 Night - Mediterranean with Greek Isles Cruise from Barcelona Ending in Civitavecchia
Starting in Barcelona, Messina, Piraeus, Santorini, Mykonos, Chania, Civitavecchia
2026 Sails: May 30, More...

Princess Tours, Sun Princess Tours

27 Night - Highlights of Spain - Tour 2C
Starting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece, Santorini, Greece, Montenegro, Corfu, Greece, Sicily (Messina), Italy, Barcelona, Spain
2026 Sails: May 31, Jun 21, Aug 23, More...

Princess Tours, Sun Princess Tours

20 Night - Highlights of Spain - Tour 2B
Starting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: May 31, Jun 21, Aug 23, More...

Princess Tours, Sun Princess Tours

13 Night - Highlights of Spain - Tour 2A
Starting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy
2026 Sails: May 31, Jun 21, Aug 23, More...

Virgin Voyages, Valiant Lady

7 Night - Spanish Isles, Rome & Cannes
Starting in Barcelona, Spain, Palma De Mallorca, Spain, Civitavecchia (Rome), Italy, Cannes, France, Ibiza, Spain, Barcelona, Spain
2026 Sails: May 31, More...

Celebrity Cruises, Celebrity Xcel

11 Night - Spain, Portugal & Morocco
Starting in Barcelona, Spain, Tangier, Morocco, Madeira (Funchal), Portugal, Lisbon, Portugal, Seville (Cadiz), Spain, Palma De Mallorca, Spain, Barcelona, Spain
2026 Sails: Jun 1, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Ibiza, Palermo, Civitavecchia, Savona, Marseille, Barcelona
2026 Sails: Jun 1, Jun 22, Jul 6, Sep 28, More...

Oceania Cruises, Oceania Nautica

Deal link -> Special

10 Night - Italian & Iberian Radiance
Starting in Barcelona, Villefranche, Florence / Pisa / Tuscany (Livorno), Rome (Civitavecchia), Alicante, Cartagena ES, Malaga, Seville (Cadiz), Lisbon
2026 Sails: Jun 1, More...

Azamara Cruises, Azamara Quest

14 Night - Spain Intensive Cruise : Valencia, Seville & Bilbao
Starting in Barcelona, Valencia, Cartagena ES, Malaga, Gibraltar, Seville, Lisbon, Porto (Leixoes), Bilbao, Pasajes, San Sebastian, Bordeaux
2026 Sails: Jun 2, More...

Azamara Cruises, Azamara Quest

25 Night - Spain & France Cruise : Seville, Bordeaux & Normandy
Starting in Barcelona, Valencia, Cartagena ES, Malaga, Gibraltar, Seville, Lisbon, Porto (Leixoes), Bilbao, Pasajes, San Sebastian, Bordeaux, Saint Peter Port, Saint-malo, Cherbourg, Rouen (Paris), Honfleur, Dunkirk, Antwerp, Amsterdam (Ijmuiden)
2026 Sails: Jun 2, More...

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