Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Cartagena ES : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Emerald Cruises, Emerald Sakara

9 Night - Spanish Shores & Beyond
Starting in Palma De Mallorca, Spain, Ibiza, Spain, Mahon, Menorca, Spain, Porto Cervo, Italy, Calvi, France, Saint-Tropez, France, Monte Carlo, Monaco, Port Vendres, France, Barcelona, Spain
2026 Sails: Sep 19, More...

Princess Cruises, Sun Princess

21 Night - The Best of the Mediterranean
Starting in Barcelona, Spain, Ibiza, Spain, Corsica (Ajaccio), France, Marseille (Provence), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece, Montenegro, Corfu, Greece, Sicily (Messina), Italy, Naples, Italy (for Capri and Pompeii), Barcelona, Spain
2026 Sails: Sep 19, More...

Princess Cruises, Sun Princess

14 Night - Mediterranean with Greece, Italy & Turkey
Starting in Barcelona, Spain, Ibiza, Spain, Corsica (Ajaccio), France, Marseille (Provence), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: Sep 19, More...

Princess Cruises, Sun Princess

7 Night - Western Mediterranean with Italy
Starting in Barcelona, Spain, Ibiza, Spain, Corsica (Ajaccio), France, Marseille (Provence), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy
2026 Sails: Sep 19, More...

Norwegian Cruise Line, Norwegian Epic

7 Night - Europe - Western Mediterranean - Barcelona
Starting in Barcelona, Spain, Nice / Monaco (Villefranche), France, Provence, Marseille, France, Livorno / Florence / Pisa, Italy, Messina, Italy, Amalfi Coast (Salerno), Italy, Civitavecchia Rome, Italy
2026 Sails: Sep 20, More...

Costa Cruise Lines, Costa Diadema

7 Night - Southern Europe Roundtrip from Barcelona
Starting in Barcelona, Spain, Marseille, France, Savona, Italy, Palma De Mallorca, Spain, Marseille, France, Savona, Italy, Barcelona, Spain
2026 Sails: Sep 21, More...

Costa Cruise Lines, Costa Diadema

4 Night - Cruise from Barcelona to Palma De Mallorca
Starting in Barcelona, Spain, Marseille, France, Savona, Italy, Palma De Mallorca, Spain
2026 Sails: Sep 21, More...

Costa Cruise Lines, Costa Fascinosa

14 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Palma De Mallorca, Malta / La Valletta, Santorini, Mykonos, Athens (Piraeus), Souda Bay, Messina (Taormina), Civitavecchia (Rome), Savona, Barcelona
2026 Sails: Sep 22, More...

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Palma De Mallorca
Starting in Palma De Mallorca, Valencia, Olbia, Civitavecchia (Rome), Savona, La Seyne (St Tropez), Palma De Mallorca
2026 Sails: Sep 22, More...

Viking Ocean, Viking Sea

10 Night - Icons of the Mediterranean
Starting in Barcelona (Tarragona), Marseille, Villefranche-Sur-Mer, Florence / Pisa (Livorno), Rome (Civitavecchia), Naples, Sicily (Messina), Sail the Ionian Sea, Crete (Heraklion), Athens (Piraeus)
2026 Sails: Sep 22, More...

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